Association of KLOTHO polymorphisms with clinical complications of sickle cell anemia

Autor: Manuela F. Hazin, Thais Helena Chaves Batista, Gabriela da Silva Arcanjo, Aderson S Araujo, Betânia Lucena Domingues Hatzlhofer, Antonio R. Lucena-Araujo, Diego Arruda Falcão, Jéssica Vitória Gadelha de Freitas Batista, Pablo Ramon Gualberto Cardoso, Maira Galdino da Rocha Pitta, Marcos André Cavalcanti Bezerra, Diego A Pereira-Martins, Igor de Farias Domingos, Fernando Ferreira Costa, Ana Claudia Mendonça dos Anjos, Isabel Weinhäuser

Publikováno v: Annals of Hematology. 100:1921-1927

The clinical and phenotypic heterogeneity of patients with sickle cell anemia (SCA) is influenced by environmental and genetic factors. Several genetic modifiers, such as the KLOTHO (KL) gene, have been associated with SCA clinical outcomes. The KL g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::40f3803ddc7dc752fca5574ce5027dd6
https://doi.org/10.1007/s00277-021-04532-w

Influence of UGT1A1 promoter polymorphism, α-thalassemia and βs haplotype in bilirubin levels and cholelithiasis in a large sickle cell anemia cohort

Autor: Gabriela da Silva Arcanjo, Antonio R. Lucena-Araujo, Marcondes José de Vasconcelos Costa Sobreira, Jéssica Vitória Gadelha de Freitas Batista, Aderson S Araujo, Igor de Farias Domingos, A. S. Araújo, Magnun N. N. Santos, Thais Helena Chaves Batista, Jéssica Maricelly Deodato de Oliveira, Marcos André Cavalcanti Bezerra, Fernanda Silva Medeiros, Diego A Pereira-Martins, Diego Arruda Falcão, Flávia Peixoto Albuquerque, Ana Claudia Mendonça dos Anjos, Manuela F. Hazin, Dulcineia M. Albuquerque, Luana Priscilla Morais Laranjeira, Betânia Lucena Domingues Hatzlhofer, Fernando Ferreira Costa, Rodrigo Marcionilo Santana

Publikováno v: Annals of Hematology. 100:903-911

Hyperbilirubinemia in patients with sickle cell anemia (SCA) as a result of enhanced erythrocyte destruction, lead to cholelithiasis development in a subset of patients. Evidence suggests that hyperbilirubinemia may be related to genetic variations,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::206bab0dc2f6da731d3bb7227211a57f
https://doi.org/10.1007/s00277-021-04422-1

Whole-exome sequencing indicates FLG2 variant associated with leg ulcers in Brazilian sickle cell anemia patients

Autor: Fernando Ferreira Costa, Aderson S Araujo, Sara Teresinha Olalla Saad, Igor de Farias Domingos, Mônica Barbosa de Melo, Iscia Lopes-Cendes, Diego Arruda Falcão, Mirta Tomie Ito, Bruno Batista de Souza, Marcos André Cavalcanti Bezerra, Murilo Guimarães Borges, Sueli Matilde da Silva-Costa, Galina Ananina, Gabriela Queila de Carvalho-Siqueira, Marilda Souza Goncalves, Antonio R. Lucena-Araujo

Publikováno v: Experimental Biology and Medicine. 244:932-939

Although sickle cell anemia results from homozygosity for a single mutation at position 7 of the β-globin chain, the clinical aspects of this condition are very heterogeneous. Complications include leg ulcers, which have a negative impact on patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93b1912fda6f36cfaf30035ea54c3b70
https://doi.org/10.1177/1535370219849592

Os polimorfismos LGALS3 + 191A e + 292C estão associados à redução dos níveis séricos de gal-3, mas não aos eventos clínicos de indivíduos com anemia falciforme

Autor: Betânia Lucena Domingues Hatzlhofer, Aderson S Araujo, Isabela Cristina Cordeiro Farias, Antonio R. Lucena-Araujo, Ana Karla da Silva Freire, Andreia Soares da Silva, Gabriela da Silva Arcanjo, Kleyton Palmeira do Ó, Maria do Socorro de Mendonça Cavalcanti, Patrícia Muniz Mendes Freire de Moura, Luydson Richardson Silva Vasconcelos, Taciana Furtado Mendonça-Belmont, Diego Arruda Falcão, Marcos André Cavalcanti Bezerra

Publikováno v: Research, Society and Development, Vol 9, Iss 9 (2020)
Research, Society and Development; Vol. 9 No. 9; e442997314
Research, Society and Development; Vol. 9 Núm. 9; e442997314
Research, Society and Development; v. 9 n. 9; e442997314
Research, Society and Development
Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI

Objective: This study aimed to evaluate whether the single nucleotide polymorphisms (SNPs) +191 C>A (rs4644) and +292 A>C (rs4652) of the LGALS3 gene and the serum levels of galectin-3 (gal-3) are associated with clinical events in patients with sick

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b9285300084f1b9b423c9f66fae0a0b
https://rsdjournal.org/index.php/rsd/article/view/7314

Os polimorfismos do gene MBL2 não estão relacionados com a ocorrência de doença cerebrovascular na anemia falciforme

Autor: Betânia Lucena Domingues Hatzlhofer, Taciana Furtado Mendonça-Belmont, Antonio R. Lucena-Araujo, Igor de Farias Domingos, João Victor Cordeiro Farias, Marcos André Cavalcanti Bezerra, Maria do Socorro de Mendonça Cavalcanti, Isabela Cristina Cordeiro Farias, Luydson Richardson Silva Vasconcelos, Patrícia Muniz Mendes Freire de Moura, Diego Arruda Falcão, Aderson S Araujo, Gabriela da Silva Arcanjo, Kleyton Palmeira do Ó, Andreia Soares da Silva, Ana Claudia Mendonça dos Anjos

Publikováno v: Research, Society and Development, Vol 9, Iss 7, Pp e439974240-e439974240 (2020)
Research, Society and Development; Vol. 9 No. 7; e439974240
Research, Society and Development; Vol. 9 Núm. 7; e439974240
Research, Society and Development; v. 9 n. 7; e439974240
Research, Society and Development
Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI

Objective: This study has as objective to verify whether MBL2 gene polymorphisms are related to the occurrence of cerebrovascular disease (CD) in sickle cell anemia (SCA) patients. Methods: Overall, 259 unrelated SCA patients were enrolled. The patie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::953ccedc820f6570ad7507edbed4127d
http://rsd.unifei.edu.br/index.php/rsd/article/view/4240