Výsledky vyhledávání - "Diego A. Calvopina"

Gamma-glutamyl transpeptidase-to-platelet ratio as a biomarker of liver disease and hepatic fibrosis severity in paediatric Cystic Fibrosis

Autor: Diego A. Calvopina, Peter J. Lewindon, Louise E. Ramm, Charlton Noble, Gunter F. Hartel, Daniel H Leung, Grant A. Ramm

Publikováno v: Journal of Cystic Fibrosis. 21:236-242

Cystic fibrosis (CF)-associated liver disease (CFLD) causes significant morbidity and mortality in children with CF. Diagnosis of liver disease prior to development of cirrhosis or portal hypertension (PHT) is challenging. While imaging modalities us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30dc9470b36226aa151dd7462206899e
https://doi.org/10.1016/j.jcf.2021.10.014

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Supersonic shear-wave elastography and APRI for the detection and staging of liver disease in pediatric cystic fibrosis

Autor: Peter Lewindon, Miranda A. Coleman, Louise E. Ramm, Grant A. Ramm, Manuel A. Fernandez-Rojo, Fariha Balouch, Gunter Hartel, Diego A. Calvopina, Charlton Noble, Anna Weis

Publikováno v: Journal of Cystic Fibrosis. 19:449-454

Current diagnostic methods for the diagnosis of Cystic fibrosis (CF)-associated liver disease (CFLD) are non-specific and assessment of disease progression is difficult prior to the advent of advanced disease with portal hypertension. This study inve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b25aace169fdd1f22aa18e9009f1756c
https://doi.org/10.1016/j.jcf.2019.06.017

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MicroRNA Sequencing Identifies a Serum MicroRNA Panel, Which Combined With Aspartate Aminotransferase to Platelet Ratio Index Can Detect and Monitor Liver Disease in Pediatric Cystic Fibrosis

Autor: Miranda A. Coleman, Mark D. Chatfield, Charlton Noble, Grant A. Ramm, Daniel H. Leung, Diego A. Calvopina, Anna Weis, Louise E. Ramm, Peter Lewindon, Manuel A. Fernandez-Rojo

Publikováno v: Hepatology. 68:2301-2316

Cystic fibrosis (CF)-associated liver disease (CFLD) is a hepatobiliary complication of CF. Current diagnostic modalities rely on non-specific assessments, while liver biopsy is the gold standard to assess severity of fibrosis. MicroRNAs (miRNAs) reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a7f675695b81fa168d89790fb520607
https://doi.org/10.1002/hep.30156

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Salivary miRNA panel to detect HPV-positive and HPV-negative head and neck cancer patients

Autor: Carolina Salazar, Chris T. Perry, Lizbeth Kenny, Diego A. Calvopina, Yunxia Wan, Dimitrios Vagenas, Chamindie Punyadeera

Publikováno v: Oncotarget

Head and neck squamous cell carcinomas (HNSCC) are a heterogeneous group of tumours that originate predominantly from the oral cavity, pharynx and larynx. Our aim was to determine whether salivary miRNA expression levels can diagnose these cancer sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d278a64469a44f692d2742ae3c19077
https://doi.org/10.18632/oncotarget.21725

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Serum MicroRNAs as Biomarkers in Hepatitis C: Preliminary Evidence of a MicroRNA Panel for the Diagnosis of Hepatocellular Carcinoma

Autor: Diego A. Calvopina, Anna Weis, Louise Marquart, Richard Skoien, Berit Genz, Grant A. Ramm

Publikováno v: International Journal of Molecular Sciences
Volume 20
Issue 4
International Journal of Molecular Sciences, Vol 20, Iss 4, p 864 (2019)

Early diagnosis of cirrhosis and hepatocellular carcinoma (HCC) due to chronic Hepatitis C (CHC) remain clinical priorities. In this pilot study, we assessed serum microRNA (miRNA) expression to distinguish cirrhosis and HCC, alone and in combination

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af72620f68c3c8f30b1317250f5f6d86
http://europepmc.org/articles/PMC6412219

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Overexpression of miRNA-25-3p inhibits Notch1 signaling and TGF-β-induced collagen expression in hepatic stellate cells

Autor: Michelle M. Hill, Fares Al-Ejeh, Grant A. Ramm, Anna Weis, Jamie R. Kutasovic, John K. Olynyk, Harley Robinson, Janina E.E. Tirnitz-Parker, Miranda A. Coleman, Diego A. Calvopina, Mariska Miranda, Nicole Cloonan, Berit Genz, Katharine M. Irvine, Francis D. Gratte

Publikováno v: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-18 (2019)

During chronic liver injury hepatic stellate cells (HSCs), the principal source of extracellular matrix in the fibrotic liver, transdifferentiate into pro-fibrotic myofibroblast-like cells - a process potentially regulated by microRNAs (miRNAs). Rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b263d8369419321a67ac75c80f52b03b
https://pubmed.ncbi.nlm.nih.gov/31189969

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miRNAs in human papilloma virus associated oral and oropharyngeal squamous cell carcinomas

Autor: Diego A. Calvopina, Chamindie Punyadeera, Carolina Salazar

Publikováno v: Expert Review of Molecular Diagnostics. 14:1033-1040

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer in the world with 600,000 new cases diagnosed annually. Tobacco and alcohol use have been associated as the principal etiological factors of this pathogenesis. The incidenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7806a0f6a88adcb5d56125b207f71153
https://doi.org/10.1586/14737159.2014.960519

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Accuracy of Transient Elastography Data Combined With APRI in Detection and Staging of Liver Disease in Pediatric Patients With Cystic Fibrosis

Autor: Mora V. Puertolas-Lopez, Louise E. Ramm, Peter Lewindon, Julie A. Wixey, Diego A. Calvopina, Daniel H. Leung, Grant A. Ramm, Charlton Noble, Gunter Hartel, Tamara N. Pereira

Publikováno v: Clinical Gastroenterology and Hepatology. 17:2561-2569.e5

Liver disease develops in 15%-72% of patients with cystic fibrosis, and 5%-10% develop cirrhosis or portal hypertension, usually during childhood. Transient elastography (TE) is a noninvasive method to measure liver stiffness. We aimed to validate it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59c9d580583a05aae27d9021de0f19f2
https://doi.org/10.1016/j.cgh.2019.03.015

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Function and Regulation of MicroRNAs and Their Potential as Biomarkers in Paediatric Liver Disease

Autor: Diego A. Calvopina, Miranda A. Coleman, Grant A. Ramm, Peter Lewindon

Publikováno v: International Journal of Molecular Sciences, Vol 17, Iss 11, p 1795 (2016)
International Journal of Molecular Sciences

MicroRNAs (miRNAs) are short non-coding RNAs involved in biological and pathological processes of every cell type, including liver cells. Transcribed from specific genes, miRNA precursors are processed in the cytoplasm into mature miRNAs and as part

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60b23c05c57a0d928c3093f8575d1008
http://www.mdpi.com/1422-0067/17/11/1795

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