Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Diego A Pereira-Martins"'
Autor:
Diego A Pereira-Martins, César Alexander Ortiz Rojas, Isabel Weinhauser, Douglas Silveira, Albertus T J Wierenga, Vincent van den Boom, Thiago M Bianco, Emanuele Ammatuna, Lynn Quek, Antonio R Lucena-Araujo, Gerwin Huls, Eduardo Rego, Jan Jacob Schuringa
Publikováno v:
HemaSphere, Vol 7, p e179931b (2023)
Externí odkaz:
https://doaj.org/article/5fedf24a1fb64b159457d1244ae87bd2
Autor:
Diego A Pereira-Martins, Vincent van den Boom, Noortje van Dijk, Isabel Weinhauser, Douglas Silveira, Thiago M Bianco, César Alexander Ortiz Rojas, Gerwin Huls, Lynn Quek, Antonio R Lucena-Araujo, Eduardo Rego, Jan Jacob Schuringa
Publikováno v:
HemaSphere, Vol 7, p e7326920 (2023)
Externí odkaz:
https://doaj.org/article/2f4c0c158a5141bb97492b1f5eec75ce
Autor:
Mariane Cristina Do Nascimento, Diego A Pereira-Martins, Guilherme Augusto Sousa Alcântara, Keli Lima, Hugo Passos Vicari, Marcelo José Pena Ferreira, Leticia Leticia Veras Costa-Lotufo, João Agostinho Machado Neto, Eduardo Magalhães Rego
Publikováno v:
HemaSphere, Vol 7, p e35451e1 (2023)
Externí odkaz:
https://doaj.org/article/b87031ab5e384a70ad7ae7a50cbefa98
Autor:
Keli Lima, Diego Antonio Pereira-Martins, Lívia Bassani Lins de Miranda, Juan Luiz Coelho-Silva, Giovana da Silva Leandro, Isabel Weinhäuser, Rita de Cássia Cavaglieri, Aline de Medeiros Leal, Wellington Fernandes da Silva, Ana Paula Alencar de Lima Lange, Elvira Deolinda Rodrigues Pereira Velloso, Emmanuel Griessinger, Jacobien R. Hilberink, Emanuele Ammatuna, Gerwin Huls, Jan Jacob Schuringa, Eduardo Magalhães Rego, João Agostinho Machado-Neto
Publikováno v:
Blood Cancer Journal, Vol 12, Iss 11, Pp 1-11 (2022)
Abstract The treatment of acute leukemia is challenging because of the genetic heterogeneity between and within patients. Leukemic stem cells (LSCs) are relatively drug-resistant and frequently relapse. Their plasticity and capacity to adapt to extra
Externí odkaz:
https://doaj.org/article/b16e466524024a6e89b2c001afb981b4
Autor:
Ayşegül Erdem, Silvia Marin, Diego A. Pereira-Martins, Marjan Geugien, Alan Cunningham, Maurien G. Pruis, Isabel Weinhäuser, Albert Gerding, Barbara M. Bakker, Albertus T. J. Wierenga, Eduardo M. Rego, Gerwin Huls, Marta Cascante, Jan Jacob Schuringa
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Inhibition of specific metabolic pathways often drives metabolic adaptation. Here, the authors show that FLT3-ITD + acute myeloid leukemia cells are OXPHOS-driven, and inhibition of complex II activity results in increased lactate influx to drive res
Externí odkaz:
https://doaj.org/article/c6190c32ad6545bcbde3640dce0f4ff7
Autor:
Ayşegül Erdem, Silvia Marin, Diego A. Pereira-Martins, Roldán Cortés, Alan Cunningham, Maurien G. Pruis, Bauke de Boer, Fiona A. J. van den Heuvel, Marjan Geugien, Albertus T. J. Wierenga, Annet Z. Brouwers-Vos, Eduardo M. Rego, Gerwin Huls, Marta Cascante, Jan Jacob Schuringa
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Acute myeloid leukemia (AML) is genetically a very heterogeneous disease. Here, Erdem et al. uncover heterogeneity in the metabolic landscape of AML and identify Pyruvate dehydrogenase kinase 1 (PDK1) as a targetable determinant of different metaboli
Externí odkaz:
https://doaj.org/article/0f8fe7450b4e4f25a3960cce038a7ad3
Autor:
Amanda Fernandes de Oliveira Costa, Leticia Olops Marani, Thiago Mantello Bianco, Adriana Queiroz Arantes, Izabela Aparecida Lopes, Diego Antonio Pereira-Martins, Leonardo Carvalho Palma, Priscila Santos Scheucher, Josiane Lilian dos Santos Schiavinato, Larissa Sarri Binelli, Cleide Araújo Silva, Susumu S. Kobayashi, João Agostinho Machado-Neto, Eduardo Magalhães Rego, Robert Samuel Welner, Lorena Lobo de Figueiredo-Pontes
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
In cancer, tumor cells and their neoplastic microenvironment can sculpt the immunogenic phenotype of a developing tumor. In this context, natural killer (NK) cells are subtypes of lymphocytes of the innate immune system recognized for their potential
Externí odkaz:
https://doaj.org/article/28e32517d513486fac8e847dcb61dbdf
Autor:
Diego A. Pereira-Martins, Igor F. Domingos, Edis Belini-Junior, Juan L. Coelho-Silva, Isabel Weinhäuser, Aderson S. Araújo, Clarisse L. Lobo, Claudia R. Bonini-Domingos, Marcos A. Bezerra, Antonio R. Lucena-Araujo
Publikováno v:
Hematology, Transfusion and Cell Therapy, Vol 43, Iss 3, Pp 243-248 (2021)
Introduction: Sickle cell anemia (SCA) is a Mendelian disorder with a heterogeneous clinical course. The reasons for this phenotypic diversity are not entirely established, but it is known that high fetal hemoglobin levels lead to a milder course of
Externí odkaz:
https://doaj.org/article/b4f7b9e9364742d191c10f93c9d5a4c7
Autor:
Diego A. Pereira-Martins, Isabel Weinhäuser, Juan Luiz Coelho-Silva, Pedro L. França-Neto, Luciana Y. Almeida, Thiago M. Bianco, Cleide L. Silva, Rafael F. França, Fabiola Traina, Eduardo M. Rego, Jan Jacob Schuringa, Antonio R. Lucena-Araujo
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-14 (2021)
Abstract Although the mixed lineage leukemia 5 (MLL5) gene has prognostic implications in acute promyelocyte leukemia (APL), the underlying mechanism remains to be elucidated. Here, we demonstrate the critical role exerted by MLL5 in APL regarding ce
Externí odkaz:
https://doaj.org/article/a952eae0379240d8894ca75104bea765
Autor:
Juan L. Coelho-Silva, Douglas R. A. Silveira, Diego A. Pereira-Martins, Cesar A. O. Rojas, Antonio R. Lucena-Araujo, Eduardo M. Rego, João A. Machado-Neto, Israel Bendit, Vanderson Rocha, Fabiola Traina
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Deregulated cellular energetics is formally incorporated as an emerging hallmark of cancer, however little is known about its processes in myelodysplastic syndromes (MDS). Using transcriptomic data of CD34+ cells from 159 MDS patients and 17
Externí odkaz:
https://doaj.org/article/8ba9e4b1885747c1968531cbed9acd10