Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Diego Casabona"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
After the COVID-19 pandemic, messenger RNA (mRNA) has revolutionized traditional vaccine manufacturing. With the increasing number of RNA-based therapeutics, valuable new scientific insights into these molecules have emerged. One fascinating area of
Externí odkaz:
https://doaj.org/article/c927bd59acf34ce4b3a8fc42e1096ca4
Autor:
Ana-María Lacosta, María Pascual-Lucas, Pedro Pesini, Diego Casabona, Virginia Pérez-Grijalba, Iván Marcos-Campos, Leticia Sarasa, Jesus Canudas, Hassnae Badi, Inmaculada Monleón, Itziar San-José, Josep Munuera, Octavio Rodríguez-Gómez, Carla Abdelnour, Asunción Lafuente, Mar Buendía, Mercè Boada, Lluis Tárraga, Agustín Ruiz, Manuel Sarasa
Publikováno v:
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-13 (2018)
Abstract Background Immunotherapy targeting the amyloid-β (Aβ) peptide is a promising strategy for the treatment of Alzheimer’s disease (AD); however, none of the active or passive vaccines tested have been demonstrated to be effective to date. W
Externí odkaz:
https://doaj.org/article/1030c599a5ae4b4d8f002a265d9af497
Autor:
Mar Buendía, Leticia Sarasa, Octavio Rodriguez-Gomez, Inmaculada Monleón, Carla Abdelnour, Virginia Pérez-Grijalba, Josep Munuera, María Pascual-Lucas, Hassnae Badi, Mercè Boada, Iván Marcos-Campos, Ana-María Lacosta, Pedro Pesini, Diego Casabona, Lluís Tárraga, Asunción Lafuente, Itziar San-José, Manuel Sarasa, Jesús Canudas, Agustín Ruiz
Publikováno v:
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-13 (2018)
Background Immunotherapy targeting the amyloid-β (Aβ) peptide is a promising strategy for the treatment of Alzheimer’s disease (AD); however, none of the active or passive vaccines tested have been demonstrated to be effective to date. We have de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43050109efbefedc7191fcc3217fd290
http://link.springer.com/article/10.1186/s13195-018-0340-8
http://link.springer.com/article/10.1186/s13195-018-0340-8
Autor:
Ana-María, Lacosta, María, Pascual-Lucas, Pedro, Pesini, Diego, Casabona, Virginia, Pérez-Grijalba, Iván, Marcos-Campos, Leticia, Sarasa, Jesus, Canudas, Hassnae, Badi, Inmaculada, Monleón, Itziar, San-José, Josep, Munuera, Octavio, Rodríguez-Gómez, Carla, Abdelnour, Asunción, Lafuente, Mar, Buendía, Mercè, Boada, Lluis, Tárraga, Agustín, Ruiz, Manuel, Sarasa
Publikováno v:
Alzheimer's Research & Therapy
Background Immunotherapy targeting the amyloid-β (Aβ) peptide is a promising strategy for the treatment of Alzheimer’s disease (AD); however, none of the active or passive vaccines tested have been demonstrated to be effective to date. We have de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::70a100f41e250fcb692e4ba06dc91dd5
https://pubmed.ncbi.nlm.nih.gov/29378651
https://pubmed.ncbi.nlm.nih.gov/29378651
Autor:
Virginia Pérez-Grijalba, Pedro Pesini, Ana M. Lacosta, Jesús Canudas, Diego Casabona, María Montañés, Manuel Sarasa, Noelia Fandos, Daniel Insua
Publikováno v:
Journal of Alzheimer's Disease
Recent advances in neuroimaging and cerebrospinal fluid (CSF) biomarker assays have provided evidence of a long preclinical stage of Alzheimer's disease (AD). This period is being increasingly targeted for secondary prevention trials of new therapies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfd8cc2d64877f249b7933404e1a0d7b
https://pubmed.ncbi.nlm.nih.gov/27567833
https://pubmed.ncbi.nlm.nih.gov/27567833
Autor:
Carlos Cativiela, Diego Casabona
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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5 pages, 3 figures, scheme 1.
This report describes the synthesis of 2-azabicyclo[2.2.2]octane-1-carboxylic acid, a constrained pipecolic acid analogue. The route gives a very good total yield starting from cheap and readily available compounds
This report describes the synthesis of 2-azabicyclo[2.2.2]octane-1-carboxylic acid, a constrained pipecolic acid analogue. The route gives a very good total yield starting from cheap and readily available compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8af341dfb64171f35e5782aab68683bc
https://doi.org/10.1016/j.tet.2006.08.006
https://doi.org/10.1016/j.tet.2006.08.006
Autor:
Diego Casabona, Carlos Cativiela
Publikováno v:
Synthesis. 2006:2440-2443
A very simple and inexpensive synthesis of the valuable intermediate 1-aminocyclopent-3-ene-1-carboxylic acid on a multigram scale and with a high overall yield (80%) is reported. The efficiency of the procedure relies on the ready accessibility and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b723ee35fec61b6522578c751632e66a
https://doi.org/10.1055/s-2006-942458
https://doi.org/10.1055/s-2006-942458
Autor:
M. Teresa García-López, Marta Gutiérrez-Rodríguez, Diana Frechilla, Carlos Cativiela, Rosario González-Muñiz, Edurne Cenarruzabeitia, Joaquín Del Río, Diego Casabona, M. Jesús Pérez de Vega, Rosario Herranz, Sergio A. Alonso De Diego, M. Luisa Jimeno
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
A suitable solid-phase approach, based on Fmoc/tBu methodology and on the use of 2-chlorotrityl resin, allowed a rapid and efficient preparation of new GPE analogues. Most of the synthesized tripeptides displayed glutamate receptor binding affinity c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c89e2ca2f598791efadd0405f85b5ed5
https://doi.org/10.1016/j.bmcl.2005.11.040
https://doi.org/10.1016/j.bmcl.2005.11.040
Autor:
Ana-María Lacosta, Manuel Sarasa, María Montañés, José Antonio Allué, Lluís Tárraga, Mercè Boada, Agustín Ruiz, Diego Casabona, Pedro Pesini, Leticia Sarasa, Virginia Pérez-Grijalba, Itziar San-José
Publikováno v:
Journal of Alzheimer's disease : JAD. 43(1)
This work was prompted by the finding that Aβ1-17 (Aβ17) appeared to be the second-most abundant cerebrospinal fluid (CSF) Aβ fragment, after Aβ40. We developed an ELISA to quantify levels of Aβ17 directly accessible in plasma (DA17), recovered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11fad146aa00a3c63716e32556fa3fbc
https://pubmed.ncbi.nlm.nih.gov/25061046
https://pubmed.ncbi.nlm.nih.gov/25061046
Publikováno v:
Journal of Alzheimer's disease : JAD. 34(1)
Alzheimer's disease is characterized by the abnormal aggregation of amyloid-β (Aβ)1-40 and Aβ1-42 peptides into fibrils. In this work, we analyzed the kinetics of Aβ1-40 and Aβ1-42 fibril formation in vitro using Thioflavin T fluorescence. We sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1b6c2766c301b0c3fcf556004e868e0
https://pubmed.ncbi.nlm.nih.gov/23160008
https://pubmed.ncbi.nlm.nih.gov/23160008