Theoretical and experimental studies on the interaction of biphenyl ligands with human and murine PD-L1: Up-to-date clues for drug design

Autor: Greta Donati, Vincenzo Maria D’Amore, Pasquale Russomanno, Linda Cerofolini, Jussara Amato, Simona Marzano, Maria Salobehaj, Domenico Rizzo, Giulia Assoni, Alfonso Carotenuto, Valeria La Pietra, Daniela Arosio, Pierfausto Seneci, Marco Fragai, Diego Brancaccio, Francesco Saverio Di Leva, Luciana Marinelli

Publikováno v: Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 3355-3368 (2023)

Today it is widely recognized that the PD-1/PD-L1 axis plays a fundamental role in escaping the immune system in cancers, so that anti-PD-1/PD-L1 antibodies have been evaluated for their antitumor properties in more than 1000 clinical trials. As a re

Externí odkaz: https://doaj.org/article/3bd14ba4f0aa401ca2a63ca4a266835e

Role of Helical Structure in MBP Immunodominant Peptides for Efficient IgM Antibody Recognition in Multiple Sclerosis

Autor: Agnieszka Staśkiewicz, Michael Quagliata, Feliciana Real-Fernandez, Francesca Nuti, Roberta Lanzillo, Vincenzo Brescia-Morra, Hendrik Rusche, Michal Jewginski, Alfonso Carotenuto, Diego Brancaccio, Rina Aharoni, Ruth Arnon, Paolo Rovero, Rafal Latajka, Anna Maria Papini

Publikováno v: Frontiers in Chemistry, Vol 10 (2022)

The involvement of Myelin Basic Protein (MBP) in Multiple Sclerosis (MS) has been widely discussed in the literature. This intrinsically disordered protein has an interesting α-helix motif, which can be considered as a conformational epitope. In thi

Externí odkaz: https://doaj.org/article/c71a478a745049bc9ab1490a141428d9

Enriching the Arsenal of Pharmacological Tools against MICAL2

Autor: Ivana Barravecchia, Elisabetta Barresi, Camilla Russo, Francesca Scebba, Chiara De Cesari, Valerio Mignucci, Davide De Luca, Silvia Salerno, Valeria La Pietra, Mariateresa Giustiniano, Sveva Pelliccia, Diego Brancaccio, Greta Donati, Federico Da Settimo, Sabrina Taliani, Debora Angeloni, Luciana Marinelli

Publikováno v: Molecules, Vol 26, Iss 24, p 7519 (2021)

Molecule interacting with CasL 2 (MICAL2), a cytoskeleton dynamics regulator, are strongly expressed in several human cancer types, especially at the invasive front, in metastasizing cancer cells and in the neo-angiogenic vasculature. Although a plet

Externí odkaz: https://doaj.org/article/8dae666ae0a641799df6e215c072523e

Intervista a Diego Brancaccio

Autor: Diego Brancaccio

Publikováno v: Giornale di Clinica Nefrologia e Dialisi, Vol 22, Iss 3 (2018)

Abstract non disponibile

Externí odkaz: https://doaj.org/article/ca53485feb8640569ba384a323ae9282

First-in-Class Cyclic Temporin L Analogue: Design, Synthesis, and Antimicrobial Assessment

Autor: Bruno Casciaro, Salvatore Di Maro, Floriana Cappiello, Stefania Galdiero, Alfonso Carotenuto, Maria Luisa Mangoni, Diego Brancaccio, Francesco Merlino, Tom N. Grossmann, Ettore Novellino, Paolo Grieco, Rosa Bellavita, Annarita Falanga, Elisabetta Buommino

Publikováno v: Journal of medicinal chemistry, 64(15), 11675-11694. American Chemical Society
Journal of Medicinal Chemistry
Bellavita, R, Casciaro, B, Di Maro, S, Brancaccio, D, Carotenuto, A, Falanga, A, Cappiello, F, Buommino, E, Galdiero, S, Novellino, E, Grossmann, T N, Mangoni, M L, Merlino, F & Grieco, P 2021, ' First-in-Class Cyclic Temporin L Analogue : Design, Synthesis, and Antimicrobial Assessment ', Journal of medicinal chemistry, vol. 64, no. 15, pp. 11675-11694 . https://doi.org/10.1021/acs.jmedchem.1c01033

The pharmacodynamic and pharmacokinetic properties of bioactive peptides can be modulated by introducing conformational constraints such as intramolecular macrocyclizations, which can involve either the backbone and/or side chains. Herein, we aimed a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb465bd9439290faeeb31e62a32610d3
https://doi.org/10.1021/acs.jmedchem.1c01033