Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Diego, Esposito"'
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
TRIM E3 ligases are key regulators of numerous cellular functions, yet their mechanism of action remains poorly understood. Here, the authors show that paralogous TRIM2 and TRIM3 adopt different self-association and activity profiles but interact in
Externí odkaz:
https://doaj.org/article/e0d261dbf55b4a48b6ab16d69d7003fe
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Multidomain proteins composed of individual domains connected by flexible linkers pose a challenge for structural studies due to their intrinsic conformational dynamics. Integrated modelling approaches provide a means to characterise protein
Externí odkaz:
https://doaj.org/article/5d70fc65487946e5b5affb3fdd65e763
Publikováno v:
Biochemical Society Transactions
TRIM proteins form a protein family that is characterized by a conserved tripartite motif domain comprising a RING domain, one or two B-box domains and a coiled-coil region. Members of this large protein family are important regulators of numerous ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5212c2098925fa4526fd37b37625817f
https://doi.org/10.1042/bst20200383
https://doi.org/10.1042/bst20200383
Tripartite motif (TRIM) proteins constitute a large family of RING-type E3 ligases that share a conserved domain architecture. TRIM2 and TRIM3 are paralogous class VII TRIM members that are expressed mainly in the brain and regulate different neurona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e54ce5189fc6c2e05082b10999f893df
Autor:
Luigi Martino, Louise Holland, Evangelos Christodoulou, Simone Kunzelmann, Diego Esposito, Katrin Rittinger
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164662 (2016)
NOD-like receptors represent an important class of germline-encoded pattern recognition receptors that play key roles in the regulation of inflammatory signalling pathways. They function as danger sensors and initiate inflammatory responses and the p
Externí odkaz:
https://doaj.org/article/39dc3b049721453aaab3493311c0252e
Dynamic Allostery in PLCγ1 and Its Modulation by a Cancer Mutation Revealed by MD Simulation and NMR
Publikováno v:
Biophysical Journal
Phosphatidylinositol phospholipase Cγ (PLCγ) is an intracellular membrane-associated second-messenger signaling protein activated by tyrosine kinases such as fibroblast growth factor receptor 1. PLCγ contains the regulatory γ-specific array (γSA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2da6e7da5e5599ad495a6db4693ffe8a
http://europepmc.org/articles/PMC6035297
http://europepmc.org/articles/PMC6035297
Publikováno v:
The Journal of Biological Chemistry
The closely related type III secretion system zinc metalloprotease effector proteins GtgA, GogA, and PipA are translocated into host cells during Salmonella infection. They then cleave nuclear factor κ-light-chain-enhancer of activated B cells (NF-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d98636c83db7c56fff12752437a72a6
http://europepmc.org/articles/PMC6166728
http://europepmc.org/articles/PMC6166728
Autor:
Regina A. Günster, Teresa L. M. Thurston, Kamel El Omari, Armin Wagner, Luigi Martino, Katrin Rittinger, Diego Esposito
Publikováno v:
Journal of Biological Chemistry. 293:5064-5078
The Salmonella secreted effector SseK3 translocates into host cells, targeting innate immune responses including NF-κB activation. SseK3 is a glycosyltransferase that transfers an N-acetylglucosamine (GlcNAc) moiety onto the guanidino group of a tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51daeac4fcf4541c734eaee78e1e4d0f
https://doi.org/10.1074/jbc.ra118.001796
https://doi.org/10.1074/jbc.ra118.001796
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e7123 (2009)
BACKGROUND:Following the amputation of a limb, newts and salamanders have the capability to regenerate the lost tissues via a complex process that takes place at the site of injury. Initially these cells undergo dedifferentiation to a state competent
Externí odkaz:
https://doaj.org/article/475515457f2148ed8b2620fba19d6387
Publikováno v:
Life Science Alliance
This study shows that members of the class VI TRIM E3 ligase family contain monomeric RING domains and display no ligase activity and may require additional regulatory events to promote ubiquitination.
TRIM E3 ubiquitin ligases regulate multiple
TRIM E3 ubiquitin ligases regulate multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89be7b946c01dd6eed166dce902465eb