Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Diego, De Stefani"'
Autor:
Giulia Di Marco, Gaia Gherardi, Agnese De Mario, Ilaria Piazza, Martina Baraldo, Andrea Mattarei, Bert Blaauw, Rosario Rizzuto, Diego De Stefani, Cristina Mammucari
Publikováno v:
Cell Death and Disease, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract MitoKATP is a channel of the inner mitochondrial membrane that controls mitochondrial K+ influx according to ATP availability. Recently, the genes encoding the pore-forming (MITOK) and the regulatory ATP-sensitive (MITOSUR) subunits of mitoK
Externí odkaz:
https://doaj.org/article/66b3a56db4114e61b4f290a6a6068a1f
Autor:
Samantha Corrà, Vanessa Checchetto, Michele Brischigliaro, Chiara Rampazzo, Emanuela Bottani, Cristina Gagliani, Katia Cortese, Cristiano De Pittà, Marco Roverso, Diego De Stefani, Sara Bogialli, Massimo Zeviani, Carlo Viscomi, Ildiko Szabò, Rodolfo Costa
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107955- (2023)
Summary: Mutations in MPV17 are a major contributor to mitochondrial DNA (mtDNA) depletion syndromes, a group of inherited genetic conditions due to mtDNA instability. To investigate the role of MPV17 in mtDNA maintenance, we generated and characteri
Externí odkaz:
https://doaj.org/article/ff2c36dac13745499ea74ac5bfd8d600
Autor:
Enrico Cortese, Alessandro Galenda, Alessia Famengo, Luca Cappellin, Marco Roverso, Alessio G. Settimi, Manuele Dabalà, Diego De Stefani, Alessandro Fassina, Gianluigi Serianni, Vanni Antoni, Lorella Navazio
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10752 (2022)
Non-thermal plasma technology is increasingly being applied in the plant biology field. Despite the variety of beneficial effects of plasma-activated water (PAW) on plants, information about the mechanisms of PAW sensing by plants is still limited. I
Externí odkaz:
https://doaj.org/article/01c2a9d4f0a147bdb0a1c3b27fb33741
Autor:
Giulia Favaro, Vanina Romanello, Tatiana Varanita, Maria Andrea Desbats, Valeria Morbidoni, Caterina Tezze, Mattia Albiero, Marta Canato, Gaia Gherardi, Diego De Stefani, Cristina Mammucari, Bert Blaauw, Simona Boncompagni, Feliciano Protasi, Carlo Reggiani, Luca Scorrano, Leonardo Salviati, Marco Sandri
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Muscle loss is associated with altered expression of proteins involved in mitochondrial homeostasis, but whether this is causative remains unclear. Here, the authors show that genetic ablation of the pro-fission protein DRP1 leads to accumulation of
Externí odkaz:
https://doaj.org/article/9c453a3351fb46c1bf8f6e6f7cadf691
Autor:
Fernanda M. Cerqueira, Sophia von Stockum, Marta Giacomello, Inna Goliand, Pamela Kakimoto, Elena Marchesan, Diego De Stefani, Alicia J. Kowaltowski, Elena Ziviani, Orian S. Shirihai
Publikováno v:
Redox Biology, Vol 37, Iss , Pp 101676- (2020)
UCH-L1 is a deubiquitinating enzyme (DUB), highly abundant in neurons, with a sub-cellular localization dependent on its farnesylation state. Despite UCH-L1′s association with familial Parkinson's Disease (PD), the effects on mitochondrial bioenerg
Externí odkaz:
https://doaj.org/article/649dc9397584410ba185030c3121ac13
Autor:
Shuangxi Li, Zhihao Wu, Yu Li, Ishaq Tantray, Diego De Stefani, Andrea Mattarei, Gopinath Krishnan, Fen-Biao Gao, Hannes Vogel, Bingwei Lu
Publikováno v:
Cell Reports, Vol 32, Iss 5, Pp 107989- (2020)
Summary: Amyotrophic lateral sclerosis (ALS) manifests pathological changes in motor neurons and various other cell types. Compared to motor neurons, the contribution of the other cell types to the ALS phenotypes is understudied. G4C2 repeat expansio
Externí odkaz:
https://doaj.org/article/ed1ad705febe49b9883e508820e1144d
Autor:
Giulia Di Marco, Francesca Vallese, Benjamin Jourde, Christian Bergsdorf, Mattia Sturlese, Agnese De Mario, Valerie Techer-Etienne, Dorothea Haasen, Berndt Oberhauser, Simone Schleeger, Giulia Minetti, Stefano Moro, Rosario Rizzuto, Diego De Stefani, Mara Fornaro, Cristina Mammucari
Publikováno v:
Cell Reports, Vol 30, Iss 7, Pp 2321-2331.e6 (2020)
Summary: Mitochondrial Ca2+ uptake depends on the mitochondrial calcium uniporter (MCU) complex, a highly selective channel of the inner mitochondrial membrane (IMM). Here, we screen a library of 44,000 non-proprietary compounds for their ability to
Externí odkaz:
https://doaj.org/article/d25f73fedd1e4a3f98bcf5f6b17f78fb
Autor:
Alexis R. Díaz-Vegas, Alex Cordova, Denisse Valladares, Paola Llanos, Cecilia Hidalgo, Gaia Gherardi, Diego De Stefani, Cristina Mammucari, Rosario Rizzuto, Ariel Contreras-Ferrat, Enrique Jaimovich
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Aim: We hypothesize that both type-1 ryanodine receptor (RyR1) and IP3-receptor (IP3R) calcium channels are necessary for the mitochondrial Ca2+ increase caused by membrane depolarization induced by potassium (or by electrical stimulation) of single
Externí odkaz:
https://doaj.org/article/6d43800ab6d14174ac682c1fbca702e6
Autor:
Cristina Mammucari, Gaia Gherardi, Ilaria Zamparo, Anna Raffaello, Simona Boncompagni, Francesco Chemello, Stefano Cagnin, Alessandra Braga, Sofia Zanin, Giorgia Pallafacchina, Lorena Zentilin, Marco Sandri, Diego De Stefani, Feliciano Protasi, Gerolamo Lanfranchi, Rosario Rizzuto
Publikováno v:
Cell Reports, Vol 10, Iss 8, Pp 1269-1279 (2015)
Muscle atrophy contributes to the poor prognosis of many pathophysiological conditions, but pharmacological therapies are still limited. Muscle activity leads to major swings in mitochondrial [Ca2+], which control aerobic metabolism, cell death, and
Externí odkaz:
https://doaj.org/article/f0b0c13e9086456a9f7009a14749ce3e
Autor:
Enrico, Zampese, David L, Wokosin, Patricia, Gonzalez-Rodriguez, Jaime N, Guzman, Tatiana, Tkatch, Jyothisri, Kondapalli, William C, Surmeier, Karis B, D'Alessandro, Diego, De Stefani, Rosario, Rizzuto, Masamitsu, Iino, Jeffery D, Molkentin, Navdeep S, Chandel, Paul T, Schumacker, D James, Surmeier
Publikováno v:
Science advances. 8(39)
How do neurons match generation of adenosine triphosphate by mitochondria to the bioenergetic demands of regenerative activity? Although the subject of speculation, this coupling is still poorly understood, particularly in neurons that are tonically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::585c2e07083b4d0136f56ffe55a7cff7
https://pubmed.ncbi.nlm.nih.gov/36179023
https://pubmed.ncbi.nlm.nih.gov/36179023