Výsledky vyhledávání - "Diedert Luc De Paep"

Akademický článek

Pancreatic acinar cell fate relies on system xC - to prevent ferroptosis during stress

Autor: Zhaolong Pan, Jan-Lars Van den Bossche, Eva Rodriguez-Aznar, Pauline Janssen, Olaya Lara, Gamze Ates, Ann Massie, Diedert Luc De Paep, Isabelle Houbracken, Marco Mambretti, Ilse Rooman

Publikováno v: Cell Death and Disease, Vol 14, Iss 8, Pp 1-10 (2023)

Abstract Acinar cell dedifferentiation is one of the most notable features of acute and chronic pancreatitis. It can also be the initial step that facilitates pancreatic cancer development. In the present study, we further decipher the precise mechan

Externí odkaz: https://doaj.org/article/adf246e9954541b490c2843a354e56e2

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Use of hyperglycemic clamp to assess pancreatectomy and islet cell autotransplant in patient with heterotaxy syndrome and dorsal pancreas agenesis leading to chronic pancreatitis

Autor: Vincent Vandecaveye, Pieter Gillard, Schalk Van der Merwe, Jacques Pirenne, Zhidong Ling, Diedert Luc De Paep, Bart Keymeulen, Geert Maleux, Yves Debaveye, Hannah van Malenstein, Hilde Verbeke, Daniel Pipeleers, Daniel Jacobs-Tulleneers-Thevissen

Publikováno v: American Journal of Transplantation. 20:3662-3666

Patients with heterotaxy syndrome (HS) can present with an associated complete dorsal pancreas agenesis (DPA). They are considered to be at increased risk for developing diabetes due to a reduced functional beta cell mass (FBM) as well as for chronic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::434abc564f91eaf02e2d1f8a701413b0
https://doi.org/10.1111/ajt.16084

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Warm ischemia time influences human islet cell isolation yield when assessed as beta cell number but not as islet equivalent number

Autor: Diedert Luc De Paep, Daniel Jacobs-Tulleneers-Thevissen

Publikováno v: American Journal of Transplantation

Due to a shortage of donation after brain death (DBD) organs, donation after circulatory death (DCD) is increasingly performed. In the field of islet transplantation, there is uncertainty regarding the suitability of DCD pancreas in terms of islet yi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f849bed1a629f63c07f227dc68af442c
https://doi.org/10.1111/ajt.16691

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Lower beta cell yield from donor pancreases after controlled circulatory death prevented by shortening acirculatory warm ischemia time and by using IGL-1 cold preservation solution

Autor: Diedert Luc De Paep, Freya Van Hulle, Daniel Pipeleers, Zhidong Ling, Jacques Pirenne, Bart Keymeulen, Marian Vanhoeij, Daniel Jacobs-Tulleneers-Thevissen

Publikováno v: PLoS ONE, Vol 16, Iss 5, p e0251055 (2021)
PLOS ONE
PLoS ONE

Organs from donors after controlled circulatory death (DCD III) exhibit a higher risk for graft dysfunction due to an initial period of warm ischemia. This procurement condition can also affect the yield of beta cells in islet isolates from donor pan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb9f98279cf020a5157d4b21e73966a
https://doaj.org/article/899f51c3f2824bec99fd18a9569bdb16

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Discovery and 3D imaging of a novel ΔNp63-expressing basal cell type in human pancreatic ducts with implications in disease

Publikováno v: Gut
Gut, BMJ Publishing Group, In press, ⟨10.1136/gutjnl-2020-322874⟩
Gut, In press, ⟨10.1136/gutjnl-2020-322874⟩
Gut, p. [1-13] (2021)

Objective: The aggressive basal-like molecular subtype of pancreatic ductal adenocarcinoma (PDAC) harbours a ΔNp63 (p40) gene expression signature reminiscent of a basal cell type. Distinct from other epithelia with basal tumours, ΔNp63+ basal cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b1753811ff45faa28755ff5c1e5e2cd
https://hal.archives-ouvertes.fr/hal-03314798/document

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Formation of amyloid in encapsulated human pancreatic and human stem cell-generated beta cell implants

Autor: Ines De Mesmaeker, Diedert Luc De Paep, Zhidong Ling, Freya Van Hulle, Krista Suenens, Daniel Jacobs-Tulleneers-Thevissen, Daniel Pipeleers, Bart Keymeulen, Pieter Gillard, Kaat De Groot, Evert Kroon, Gunilla T. Westermark, Robert Hilbrands, Geert Stangé

Publikováno v: American Journal of Transplantation

Detection of amyloid in intraportal islet implants of type 1 diabetes patients has been proposed as cause in their functional decline. The present study uses cultured adult human islets devoid of amyloid to examine conditions of its formation. After

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d69a222cb94b81c2c403e117b80d6a61
https://lirias.kuleuven.be/handle/123456789/664382

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Insulitis in the pancreas of non-diabetic organ donors under age 25 years with multiple circulating autoantibodies against islet cell antigens

Autor: Silke Smeets, Peter In't Veld, Ilse Weets, Katrijn Verhaeghen, Zhidong Ling, Bart Van Der Auwera, Bart Keymeulen, Diedert Luc De Paep, Frans Gorus, Geert Stangé

Publikováno v: Virchows Archiv

Autoantibodies against islet cell antigens are routinely used to identify subjects at increased risk of symptomatic type 1 diabetes, but their relation to the intra-islet pathogenetic process that leads to positivity for these markers is poorly under

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::109a7b6ccbe8db0b40b0a07970d0ad1b
https://pubmed.ncbi.nlm.nih.gov/33594586

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MECOM permits pancreatic acinar cell dedifferentiation avoiding cell death under stress conditions

Autor: Ellis Michiels, Patrick Jacquemin, Ilse Rooman, Mineo Kurokawa, Yves Heremans, Diedert Luc De Paep, Isabelle Houbracken, Luc Bouwens, Jonathan Baldan, Susumu Goyama, Elyne Backx, Mathias Van Bulck, Elke Wauters

Publikováno v: Cell death and differentiation, Vol. 28, no.9, p. 2601-2615 (2021)
Cell Death and Differentiation

Maintenance of the pancreatic acinar cell phenotype suppresses tumor formation. Hence, repetitive acute or chronic pancreatitis, stress conditions in which the acinar cells dedifferentiate, predispose for cancer formation in the pancreas. Dedifferent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfdccca3d6f1cc065e71875c4bb08fcc
https://doi.org/10.1101/2020.08.21.260539

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Evidence of Tissue Repair in Human Donor Pancreas After Prolonged Duration of Stay in Intensive Care

Autor: Silke Smeets, Wilfried Cools, Gunter Leuckx, Pieter In 'T Veld, Zhidong Ling, Nico De Leu, Diedert Luc De Paep, Geert Stangé, Lisbeth Roelants

Publikováno v: Diabetes. 69(3)

M2 macrophages play an important role in tissue repair and regeneration. They have also been found to modulate β-cell replication in mouse models of pancreatic injury and disease. We previously reported that β-cell replication is strongly increased

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29db9a5211e3d499dedfef051bef3d52
https://pubmed.ncbi.nlm.nih.gov/31843955

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