Sex-specific cardiac remodeling in early and advanced stages of hypertrophic cardiomyopathy.

Autor: Louise L A M Nijenkamp, Ilse A E Bollen, Hans W M Niessen, Cris G Dos Remedios, Michelle Michels, Corrado Poggesi, Carolyn Y Ho, Diederik W D Kuster, Jolanda van der Velden

Publikováno v: PLoS ONE, Vol 15, Iss 5, p e0232427 (2020)

Hypertrophic cardiomyopathy (HCM) is the most frequent genetic cardiac disease with a prevalence of 1:500 to 1:200. While most patients show obstructive HCM and a relatively stable clinical phenotype (stage II), a small group of patients progresses t

Externí odkaz: https://doaj.org/article/591161600ceb43598f6013c5668a4b68

Large-Scale Contractility Measurements Reveal Large Atrioventricular and Subtle Interventricular Differences in Cultured Unloaded Rat Cardiomyocytes

Autor: Edgar E. Nollet, Emmy M. Manders, Max Goebel, Valentijn Jansen, Cord Brockmann, Jorrit Osinga, Jolanda van der Velden, Michiel Helmes, Diederik W. D. Kuster

Publikováno v: Frontiers in Physiology, Vol 11 (2020)

The chambers of the heart fulfill different hemodynamic functions, which are reflected in their structural and contractile properties. While the atria are highly elastic to allow filling from the venous system, the ventricles need to be able to produ

Externí odkaz: https://doaj.org/article/828eff94062f4859ba1a8aa52304554c

Mitochondrial dysfunction in human hypertrophic cardiomyopathy is linked to cardiomyocyte architecture disruption and corrected by improving NADH-driven mitochondrial respiration

Autor: Edgar E Nollet, Inez Duursma, Anastasiya Rozenbaum, Moritz Eggelbusch, Rob C I Wüst, Stephan A C Schoonvelde, Michelle Michels, Mark Jansen, Nicole N van der Wel, Kenneth C Bedi, Kenneth B Margulies, Jeff Nirschl, Diederik W D Kuster, Jolanda van der Velden

Publikováno v: Nollet, E E, Duursma, I, Rozenbaum, A, Eggelbusch, M, Wüst, R C I, Schoonvelde, S A C, Michels, M, Jansen, M, van der Wel, N N, Bedi, K C, Margulies, K B, Nirschl, J, Kuster, D W D & van der Velden, J 2023, ' Mitochondrial dysfunction in human hypertrophic cardiomyopathy is linked to cardiomyocyte architecture disruption and corrected by improving NADH-driven mitochondrial respiration ', European heart journal . https://doi.org/10.1093/eurheartj/ehad028
European heart journal. Oxford University Press

Aims Genetic hypertrophic cardiomyopathy (HCM) is caused by mutations in sarcomere protein-encoding genes (i.e. genotype-positive HCM). In an increasing number of patients, HCM occurs in the absence of a mutation (i.e. genotype-negative HCM). Mitocho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbdc2e438828d47bff141acdc72a2c34
https://hdl.handle.net/1871.1/0946409f-827c-4433-af9c-265b50db328c

Amino terminus of cardiac myosin binding protein-C regulates cardiac contractility

Autor: Richard J. Gilbert, Thomas C. Irving, David M. Warshaw, Sakthivel Sadayappan, Weikang Ma, James W. McNamara, Gina Kuffel, Mayandi Sivaguru, Diederik W. D. Kuster, Paul M.L. Janssen, Burns C. Blaxall, Mohit Kumar, Dana M. Leichter, John N. Lorenz, Kyounghwan Lee, Michael J. Previs, Roger Craig, Michelle L. Nieman, Brian Lin, Thomas L. Lynch, Rohit R. Singh, Pieter P. de Tombe, Aaron M. Gibson, Michael J. Zilliox, Owen P. Leary

Publikováno v: Lynch, T L, Kumar, M, McNamara, J W, Kuster, D W D, Sivaguru, M, Singh, R R, Previs, M J, Lee, K H, Kuffel, G, Zilliox, M J, Lin, B L, Ma, W, Gibson, A M, Blaxall, B C, Nieman, M L, Lorenz, J N, Leichter, D M, Leary, O P, Janssen, P M L, de Tombe, P P, Gilbert, R J, Craig, R, Irving, T, Warshaw, D M & Sadayappan, S 2021, ' Amino terminus of cardiac myosin binding protein-C regulates cardiac contractility ', Journal of Molecular and Cellular Cardiology, vol. 156, pp. 33-44 . https://doi.org/10.1016/j.yjmcc.2021.03.009
Journal of Molecular and Cellular Cardiology
Journal of Molecular and Cellular Cardiology, Elsevier, 2021, 156, pp.33-44. ⟨10.1016/j.yjmcc.2021.03.009⟩
J Mol Cell Cardiol
Journal of Molecular and Cellular Cardiology, 156, 33-44. Academic Press Inc.

International audience; Phosphorylation of cardiac myosin binding protein-C (cMyBP-C) regulates cardiac contraction through modulation of actomyosin interactions mediated by the protein's amino terminal (N′)-region (C0-C2 domains, 358 amino acids).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9aaf27df6df4e97fdee0c961f48de4d
https://doi.org/10.1016/j.yjmcc.2021.03.009

The antibiotic doxycycline impairs cardiac mitochondrial and contractile function

Autor: Diederik W. D. Kuster, Michel van Weeghel, Vida Alizadeh Tazehkandi, Luciënne Baks-Te Bulte, Gustav J. Strijkers, Bram F. Coolen, Ntsiki M. Held, Bianca J. J. M. Brundel, Riekelt H. Houtkooper, Mariah R R Daal, Marit Wiersma, Rob C. I. Wüst

Publikováno v: Wüst, R C I, Coolen, B F, Held, N M, Daal, M R R, Tazehkandi, V A, Baks-Te Bulte, L, Wiersma, M, Kuster, D W D, Brundel, B J J M, van Weeghel, M, Strijkers, G J & Houtkooper, R H 2021, ' The antibiotic doxycycline impairs cardiac mitochondrial and contractile function ', International Journal of Molecular Sciences, vol. 22, no. 8, 4100 . https://doi.org/10.3390/ijms22084100
International journal of molecular sciences, 22(8):4100. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, 22(8):4100, 1-19. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences
Volume 22
Issue 8
Wüst, R C I, Coolen, B F, Held, N M, Daal, M R R, Tazehkandi, V A, Baks-Te Bulte, L, Wiersma, M, Kuster, D W D, Brundel, B J J M, van Weeghel, M, Strijkers, G J & Houtkooper, R H 2021, ' The antibiotic doxycycline impairs cardiac mitochondrial and contractile function ', International Journal of Molecular Sciences, vol. 22, no. 8, 4100, pp. 1-19 . https://doi.org/10.3390/ijms22084100
International Journal of Molecular Sciences, 22(8):4100. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, Vol 22, Iss 4100, p 4100 (2021)

Tetracycline antibiotics act by inhibiting bacterial protein translation. Given the bacterial ancestry of mitochondria, we tested the hypothesis that doxycycline—which belongs to the tetracycline class—reduces mitochondrial function, and results

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba143ec8e34cf744f53dea11e2bd5101
https://doi.org/10.3390/ijms22084100