Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Diederich, Ann M."'
Autor:
Frederick G. Vogt, Yemane W. Andemichael, Sonja Sharpe, Lori Wernersbach, Susan V. Downing, Daniel B. Patience, Julie Tsui, Peng Liu, Lynette M. Oh, Wenning Dai, Jacalyn S. Clawson, Leon Zhou, James T. Wertman, Alan J. Freyer, Joseph Sisko, Jun Chen, Jun Wang, Edward C. Webb, Diederich Ann M
Publikováno v:
Organic Process Research & Development. 13:729-738
A scalable synthesis of a novel pleuromutilin-based antibiotic is reported. The synthesis features the scale-up of an interesting skeletal rearrangement of the pleuromutilin core and isolation of a highly purified product despite starting with relati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1c091505eda6c4da66da24f77dd243d
https://doi.org/10.1021/op900104g
https://doi.org/10.1021/op900104g
Autor:
Robert A. Carlton, Diederich Ann M, Lee M. Katrincic, Yan T. Sun, Frederick G. Vogt, Ronald L. Mueller
Publikováno v:
International Journal of Pharmaceutics. 366:1-13
Solid-state characterization methods are used to study a dimorphic pharmaceutical compound and select a form for development. Polymorph screening found that [4-(4-chloro-3-fluorophenyl)-2-[4-(methyloxy)phenyl]-1,3-thiazol-5-yl] acetic acid can crysta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abfc13b1a4f96dfefaaa70393024af86
https://doi.org/10.1016/j.ijpharm.2008.08.044
https://doi.org/10.1016/j.ijpharm.2008.08.044
Autor:
Jennifer F. Toczko, Bobby N. Glover, Mark B. Mitchell, John Corona, Kim A. Harvey, Yong Zhang, Diederich Ann M, Mark D. Trone, Kae M. Bullock, Delphilia Burton, Robert Yule
Publikováno v:
Organic Process Research & Development. 13:303-309
Two short, high-yielding routes to the selective PPARγ agonist GSK376501A were developed and carried out on scale. The key bond -forming reaction in each synthesis was the substitution of a 3,5-difluoro or 3,5-dibromo aryl intermediate with 2-methox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a98b4509886338938a891008ee2efc3
https://doi.org/10.1021/op800211c
https://doi.org/10.1021/op800211c
Autor:
Lee M. Katrincic, Gary E. Zuber, Charles DeBrosse, Frederick G. Vogt, Jeffery L. Wood, Qiaogong Su, Philip C. Dell'orco, Diederich Ann M, Ronald L. Mueller, David J. Busby
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 40:1080-1088
Topotecan hydrochloride, a pharmaceutical compound developed as a treatment for cancer, exhibits variable hydration states in a crystalline solid form chosen for manufacturing. This variability requires additional controls for successful development,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b22a1733181d1f89f72397a96e37b7a
https://doi.org/10.1016/j.jpba.2005.08.032
https://doi.org/10.1016/j.jpba.2005.08.032
Autor:
Webb Kevin, Mark A. Olsen, Vance J. Novack, Wilford Mendelson, Neil F. Badham, Philip C. Dell'orco, Paul G. Cummings, Abu M. Rustum, Chen Jianhao, Eldridge Ann Marie, Shawn Yang, Robert John Mills, Diederich Ann M
Publikováno v:
Organic Process Research & Development. 7:101-108
The synthesis of SB-207499 is described. Investigation and development of new strategies for the homologation of ketone, 4-cyano-4-[3-(cyclopentyloxy)-4-(methoxyphenyl)]-cyclohexan-1-one 2 are desc...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::202cdbed57e23646b1c19bd5501f403c
https://doi.org/10.1021/op025584z
https://doi.org/10.1021/op025584z
Autor:
Webb Kevin, Conrad J. Kowalski, Li Liu, Vance J. Novack, Wilford Mendelson, Neil F. Badham, Lewis B. Killmer, Drake S. Eggleston, Alan J. Freyer, Diederich Ann M, Andrew Allen, John J. Filan, Jennifer Yang, Frederick G. Vogt
Publikováno v:
The Journal of organic chemistry. 67(15)
A convenient two-step homologation of both aliphatic and aromatic ketones to the corresponding carboxylic acid has been developed. First ketones were converted to epoxynitriles with the Darzens reaction. Second, a Lewis acid mediated rearrangement of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::289f2d1f25679c956dfc8a1038c9c018
https://pubmed.ncbi.nlm.nih.gov/12126449
https://pubmed.ncbi.nlm.nih.gov/12126449
Autor:
Thomas Thurston, Patrick Ng, Susan E. Barnes, Jo Ann Coleman, Katherine Bakeev, Darryl Ertl, James W. Rydzak, Dharmesh S. Bhanushali, Diederich Ann M
Publikováno v:
Analytical Methods. 2:1890
We report the successful application of in situ diffuse reflectance near-infrared (NIR) spectroscopy for characterization of the solvent mediated polymorphic form transformation of pazopanib hydrochloride. Crystal form is a critical quality attribute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e98a9919b07d9ec232a8b22278fd16b4
https://doi.org/10.1039/c0ay00376j
https://doi.org/10.1039/c0ay00376j
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Autor:
Badham, Neil F., Mendelson, Wilford L., Allen, Andrew, Diederich, Ann M., Eggleston, Drake S., Filan, John J., Freyer, Alan J., Novack, Lewis B., Vogt, Frederick G., Webb, Kevin S., Yang, Jennifer
Publikováno v:
Journal of Organic Chemistry; 7/26/2002, Vol. 67 Issue 15, p5440, 4p, 5 Diagrams, 2 Charts
Autor:
Diederich, Ann M., Ryckman, David M.
Publikováno v:
In Tetrahedron Letters 1993 34(39):6169-6172