Passive immunotherapy with a novel antibody against 3pE-modified Aβ demonstrates potential for enhanced efficacy and favorable safety in combination with BACE inhibitor treatment in plaque-depositing mice

Autor: Jonathan Janssens, Bart Hermans, Marc Vandermeeren, Erio Barale-Thomas, Marianne Borgers, Roland Willems, Greet Meulders, Cindy Wintmolders, Dries Van den Bulck, Astrid Bottelbergs, Luc Ver Donck, Peter Larsen, Dieder Moechars, Wilson Edwards, Marc Mercken, Bianca Van Broeck

Publikováno v: Neurobiology of Disease, Vol 154, Iss , Pp 105365- (2021)

The imbalance between production and clearance of amyloid β (Aβ) peptides and their resulting accumulation in the brain is an early and crucial step in the pathogenesis of Alzheimer's disease (AD). Therefore, Aβ is strongly positioned as a promisi

Externí odkaz: https://doaj.org/article/7f712f2755314a818f17894b585c61e7

Synaptic dysfunction in hippocampus of transgenic mouse models of Alzheimer's disease: A multi-electrode array study

Autor: Seon-Ah Chong, Iryna Benilova, Hamdy Shaban, Bart De Strooper, Herman Devijver, Dieder Moechars, Wolfgang Eberle, Carmen Bartic, Fred Van Leuven, Geert Callewaert

Publikováno v: Neurobiology of Disease, Vol 44, Iss 3, Pp 284-291 (2011)

APP.V717I and Tau.P301L transgenic mice develop Alzheimer's disease pathology comprising important aspects of human disease including increased levels of amyloid peptides, cognitive and motor impairment, amyloid plaques and neurofibrillary tangles. T

Externí odkaz: https://doaj.org/article/31bb7ad6c2b84d6eb980e9b20926141c

Behavioral Disturbances without Amyloid Deposits in Mice Overexpressing Human Amyloid Precursor Protein with Flemish (A692G) or Dutch (E693Q) Mutation

Autor: Samir Kumar-Singh, Ilse Dewachter, Dieder Moechars, Ursula Lübke, Chris De Jonghe, Chantal Ceuterick, Frédéric Checler, Asha Naidu, Barbara Cordell, Patrick Cras, Christine Van Broeckhoven, Fred Van Leuven

Publikováno v: Neurobiology of Disease, Vol 7, Iss 1, Pp 9-22 (2000)

The contribution of mutations in the amyloid precursor protein (APP) gene known as Flemish (APP/A692G) and Dutch (APP/E693Q) to the pathogenesis of Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis of the Dutch type, respectivel

Externí odkaz: https://doaj.org/article/173fd9a8f7dc41d4b19882d787d25ab9

Absence of Uptake and Prion-Like Spreading of Alpha-Synuclein and Tau After Intravitreal Injection of Preformed Fibrils

Autor: Michel Mahieu, Lies De Groef, Jessie Van Houcke, Sophie Van Pottelberge, Dieder Moechars, Jeroen Aerts, Lien Veys, Audrey Coens, Ronald Melki, Louis De Muynck

Publikováno v: Frontiers in Aging Neuroscience
Frontiers in Aging Neuroscience, Vol 12 (2021)
Frontiers in Aging Neuroscience, 2021, 12, pp.614587. ⟨10.3389/fnagi.2020.614587⟩
Frontiers in Aging Neuroscience, Frontiers, 2021, 12, pp.614587. ⟨10.3389/fnagi.2020.614587⟩

Although very different in etiology and symptoms, numerous neurodegenerative diseases can be classified as proteinopathies. More so, evidence indicates that the key misfolded proteins at the basis of different neuropathies might share common mechanis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635cd3e6071dbceec1dda45168b930fa
https://pubmed.ncbi.nlm.nih.gov/33519421

Progressive leukoencephalopathy impairs neurobehavioral development in sialin-deficient mice

Autor: Elly Verbeek, Hinrich W. H. Göhlmann, Marion Crauwels, Dieder Moechars, Frans W. Verheijen, Rachel Schot, Rudi D'Hooge, Nathalie Van Acker, Stijn Stroobants, An De Bondt, Grazia M.S. Mancini, Luc Andries, Guy Daneels, Michiel W.M. Knaapen, Ilse Goris

Publikováno v: Experimental Neurology. 291:106-119

Slc17a5(-/-) mice represent an animal model for the infantile form of sialic acid storage disease (SASD). We analyzed genetic and histological time-course expression of myelin and oligodendrocyte (OL) lineage markers in different parts of the CNS, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::470d22f55e736a062f60e44e37c917fd