Výsledky vyhledávání - "Diede Oudshoorn"

Akademický článek

Expression and Cleavage of Middle East Respiratory Syndrome Coronavirus nsp3-4 Polyprotein Induce the Formation of Double-Membrane Vesicles That Mimic Those Associated with Coronaviral RNA Replication

Autor: Diede Oudshoorn, Kevin Rijs, Ronald W. A. L. Limpens, Kevin Groen, Abraham J. Koster, Eric J. Snijder, Marjolein Kikkert, Montserrat Bárcena

Publikováno v: mBio, Vol 8, Iss 6 (2017)

ABSTRACT Betacoronaviruses, such as Middle East respiratory syndrome coronavirus (MERS-CoV), are important pathogens causing potentially lethal infections in humans and animals. Coronavirus RNA synthesis is thought to be associated with replication o

Externí odkaz: https://doaj.org/article/a3a7cf2cc99549698cbfbe0f6767b044

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Akademický článek

Antiviral Innate Immune Response Interferes with the Formation of Replication-Associated Membrane Structures Induced by a Positive-Strand RNA Virus

Autor: Diede Oudshoorn, Barbara van der Hoeven, Ronald W. A. L. Limpens, Corrine Beugeling, Eric J. Snijder, Montserrat Bárcena, Marjolein Kikkert

Publikováno v: mBio, Vol 7, Iss 6 (2016)

ABSTRACT Infection with nidoviruses like corona- and arteriviruses induces a reticulovesicular network of interconnected endoplasmic reticulum (ER)-derived double-membrane vesicles (DMVs) and other membrane structures. This network is thought to acco

Externí odkaz: https://doaj.org/article/ee503db994724955acf327daa20a70c9

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Akademický článek

HERC6 is the main E3 ligase for global ISG15 conjugation in mouse cells.

Autor: Diede Oudshoorn, Sander van Boheemen, Maria Teresa Sánchez-Aparicio, Ricardo Rajsbaum, Adolfo García-Sastre, Gijs A Versteeg

Publikováno v: PLoS ONE, Vol 7, Iss 1, p e29870 (2012)

Type I interferon (IFN) stimulates expression and conjugation of the ubiquitin-like modifier IFN-stimulated gene 15 (ISG15), thereby restricting replication of a wide variety of viruses. Conjugation of ISG15 is critical for its antiviral activity in

Externí odkaz: https://doaj.org/article/c0908859f7b340cdb01c0997f295e4f9

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MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment

Autor: Bart L. Haagmans, Yvonne van der Meer, Bernadette G. van den Hoogen, Diede Oudshoorn, V. Stalin Raj, Adriaan H. de Wilde, Ronald W. A. L. Limpens, Montserrat Bárcena, Clara C. Posthuma, Eric J. Snijder, Theo M. Bestebroer, Stefan van Nieuwkoop

Publikováno v: Journal of General Virology
Journal of General Virology; Vol 94
Journal of General Virology, 94, 1749-1760. Microbiology Society
The Journal of General Virology

Coronavirus (CoV) infections are commonly associated with respiratory and enteric disease in humans and animals. The 2003 outbreak of severe acute respiratory syndrome (SARS) highlighted the potentially lethal consequences of CoV-induced disease in h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36335086f2b2bad39d48264f0827a963
https://doi.org/10.1099/vir.0.052910-0

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Biogenesis and architecture of arterivirus replication organelles

Autor: Eric J. Snijder, Montserrat Bárcena, Diede Oudshoorn, Abraham J. Koster, van der Hoeven B, Marjolein Kikkert

Publikováno v: Virus Research, 220, 70-90. ELSEVIER SCIENCE BV
Virus Research

Highlights • Arterivirus RNA synthesis presumably is associated with double-membrane vesicles (DMVs). • Putative intermediates in DMV formation were detected in infected cells. • Arterivirus-induced DMVs form a highly interconnected reticuloves

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::050a8d71fe947b9d7bf82bd6fa3f5b0a
https://hdl.handle.net/1887/99368

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Regulation of the innate immune system by ubiquitin and ubiquitin-like modifiers

Autor: Gijs A. Versteeg, Marjolein Kikkert, Diede Oudshoorn

Publikováno v: Cytokine and Growth Factor Reviews, 23(6), 273-282
Cytokine & Growth Factor Reviews

Detection of invading pathogens by pattern recognition receptors (PRRs) is crucial for the activation of the innate immune response. These sensors signal through intertwining signaling cascades which result in the expression of pro-inflammatory cytok

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f255ac298c1d4d78b111b173783f9559
https://hdl.handle.net/1887/99058

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HERC6 is the main E3 ligase for global ISG15 conjugation in mouse cells

Autor: Adolfo García-Sastre, Ricardo Rajsbaum, Sander van Boheemen, Gijs A. Versteeg, Maria Teresa Sánchez-Aparicio, Diede Oudshoorn

Publikováno v: PLoS ONE
PLoS ONE, Vol 7, Iss 1, p e29870 (2012)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c95e553cb33ec9f773d2f23bd720c03
https://pubmed.ncbi.nlm.nih.gov/22272257

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[Untitled]

Autor: Corrine Beugeling, Jessica Ruinard, Diede Oudshoorn, Marjolein Kikkert, Jochem Pronk, Montserrat Bárcena, Ronald W. A. L. Limpens, Eric J. Snijder

Publikováno v: Cytokine. 63:288

The antiviral innate immune response is built around the prompt recognition of pathogen-associated molecular patterns (PAMPs) and the subsequent inhibition of the replication of the associated virus until the adaptive immune response is activated for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::39744e0622a47558bedbe275a4f3620f
https://doi.org/10.1016/j.cyto.2013.06.196

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