Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Diede Houbaert"'
Autor:
Diede Houbaert, Apostolos Panagiotis Nikolakopoulos, Kathryn A. Jacobs, Odeta Meçe, Jana Roels, Gautam Shankar, Madhur Agrawal, Sanket More, Maarten Ganne, Kristine Rillaerts, Louis Boon, Magdalena Swoboda, Max Nobis, Larissa Mourao, Francesca Bosisio, Niels Vandamme, Gabriele Bergers, Colinda L.G.J. Scheele, Patrizia Agostinis
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114020- (2024)
Summary: Lymphatic endothelial cells (LECs) of the lymph node (LN) parenchyma orchestrate leukocyte trafficking and peripheral T cell dynamics. T cell responses to immunotherapy largely rely on peripheral T cell recruitment in tumors. Yet, a systemat
Externí odkaz:
https://doaj.org/article/dca7f3404ac04b61a443f7d540320e6d
Autor:
Jelle Verhoeven, Kathryn A Jacobs, Francesca Rizzollo, Francesca Lodi, Yichao Hua, Joanna Poźniak, Adhithya Narayanan Srinivasan, Diede Houbaert, Gautam Shankar, Sanket More, Marco B Schaaf, Nikolina Dubroja Lakic, Maarten Ganne, Jochen Lamote, Johan Van Weyenbergh, Louis Boon, Oliver Bechter, Francesca Bosisio, Yasuo Uchiyama, Mathieu JM Bertrand, Jean Christophe Marine, Diether Lambrechts, Gabriele Bergers, Madhur Agrawal, Patrizia Agostinis
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 12, Pp 1-25 (2023)
Abstract Tumor endothelial cells (TECs) actively repress inflammatory responses and maintain an immune‐excluded tumor phenotype. However, the molecular mechanisms that sustain TEC‐mediated immunosuppression remain largely elusive. Here, we show t
Externí odkaz:
https://doaj.org/article/bbcea8700d3946d0a54b3724c68d12c4
Autor:
Odeta Meçe, Diede Houbaert, Maria-Livia Sassano, Tania Durré, Hannelore Maes, Marco Schaaf, Sanket More, Maarten Ganne, Melissa García-Caballero, Mila Borri, Jelle Verhoeven, Madhur Agrawal, Kathryn Jacobs, Gabriele Bergers, Silvia Blacher, Bart Ghesquière, Mieke Dewerchin, Johan V. Swinnen, Stefan Vinckier, María S. Soengas, Peter Carmeliet, Agnès Noël, Patrizia Agostinis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Autophagy is essential to endothelial cell homeostasis. Here the authors show that lipophagy in LEC supports fatty acid oxidation to sustain a mitochondrial-Prox1 gene expression circuit and promote response of LEC to lymphangiogenic mediators.
Externí odkaz:
https://doaj.org/article/6f053768112c4a3e957fc921d9943221
Autor:
Marco B. Schaaf, Diede Houbaert, Odeta Meçe, San Kit To, Maarten Ganne, Hannelore Maes, Patrizia Agostinis
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Cancer cell-stromal cell crosstalk is orchestrated by a plethora of ligand-receptor interactions generating a tumor microenvironment (TME) which favors tumor growth. The high pro-angiogenic nature of the TME perpetuates the chaotic network of structu
Externí odkaz:
https://doaj.org/article/2b8edf2f58d5435990cab0d500e19790
Publikováno v:
Autophagy. 19:1351-1353
Lymphatic endothelial cells (LECs) exploit fatty acid oxidation (FAO) to grow and to maintain lymphatic vessel identity through the epigenetic regulation of the essential transcription factor PROX1. In our recent study, we found that LEC-specific los
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4698f00b17cbf4ddd6d7a0edc714cc40
https://doi.org/10.1080/15548627.2022.2117513
https://doi.org/10.1080/15548627.2022.2117513
Publikováno v:
Cell Death and Differentiation
In mammalian cells, autophagy is the major pathway for the degradation and recycling of obsolete and potentially noxious cytoplasmic materials, including proteins, lipids, and whole organelles, through the lysosomes. Autophagy maintains cellular and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deda9c5c3a6c8ff8ba81a699edb4c43c
https://doi.org/10.1038/s41418-019-0287-8
https://doi.org/10.1038/s41418-019-0287-8
Autor:
Odeta Mece, Diede Houbaert, Tania Durré, Hannelore Maes, Marco Schaaf, Sanket More, Maarten Ganne, Melissa García-Caballero, Mila Borri, Jelle Verhoeven, Silvia Blacher, Bart Ghesquière, Mieke Dewerchin, Johannes Swinnen, Stefan Vinckier, Maria Soengas, Peter Carmeliet, Agnès Noel, Patrizia Agostinis
Autophagy has an emerging vasculoprotective role but whether and how it regulates lymphatic endothelial cells (LEC) and lymphangiogenesis is unknown. Here, we show that genetic deficiency of autophagy in LEC impairs the responses to VEGF-C and injury
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3d831b67d98d927664879d691c11830
https://doi.org/10.21203/rs.3.rs-403701/v1
https://doi.org/10.21203/rs.3.rs-403701/v1
Autor:
Hannelore Maes, Diede Houbaert, Patrizia Agostinis, Maarten Ganne, Marco B.E. Schaaf, Odeta Mece, San Kit To
Publikováno v:
Frontiers in Oncology
Frontiers in Oncology, Vol 9 (2019)
Frontiers in Oncology, Vol 9 (2019)
Cancer cell-stromal cell crosstalk is orchestrated by a plethora of ligand-receptor interactions generating a tumor microenvironment (TME) which favors tumor growth. The high pro-angiogenic nature of the TME perpetuates the chaotic network of structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b67c311c2c10a3d02f71f8cf0a1c0d3
https://lirias.kuleuven.be/handle/123456789/636707
https://lirias.kuleuven.be/handle/123456789/636707