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AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-xL, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia

Autor: Shenghua Wen, Srividya B. Balachander, Francis D. Gibbons, Michael Zinda, William McCoull, Nancy Su, Barry R. Davies, Stephen E. Kurtz, Terry MacIntyre, Edward J. Hennessy, Martin Wild, Paula Lewis, Ricky W. Johnstone, Jamal Carlos Saeh, Kathleen A. Burke, Omid Tavana, Andrea Newbold, Elizabeth A. Coker, Alwin Schuller, Justin Cidado, Diebold R Bruce, Tristan J. Lubinski, Steven Criscione, J. Paul Secrist, Kate Byth, Gareth P. Gregory, Deborah Lawson, Ammar Adam, Shannon K. McWeeney, Stephen Fawell, Thomas Gero, Jeffrey G. Varnes, Eric Gangl, Patricia Jaaks, Jeffrey W. Tyner, Mathew J. Garnett, Areya Tabatabai, Stephanos Ioannidis

Publikováno v: Clinical Cancer Research. 26:6535-6549

Purpose: Targeting Bcl-2 family members upregulated in multiple cancers has emerged as an important area of cancer therapeutics. While venetoclax, a Bcl-2–selective inhibitor, has had success in the clinic, another family member, Bcl-xL, has also e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::564420d79c6feacf9af617f03b6937bc
https://doi.org/10.1158/1078-0432.ccr-20-0863

Effect of introduction of routine single shot adductor canal block in primary total knee arthroplasty in a rural Australian setting.

Autor: Otieno J; Orthopaedics, Hunter New England Health, New Lambton, New South Wales, Australia., Ng R; Critical Care, HNELHD, New Lambton, New South Wales, Australia., Graffen S; Geriatric Medicine, Bachelor of Medicine, Hunter New England Local Health District, New Lambton, New South Wales, Australia., Diebold R; Geriatric Medicine, Bachelor of Medicine, Hunter New England Local Health District, New Lambton, New South Wales, Australia.

Publikováno v: ANZ journal of surgery [ANZ J Surg] 2022 Nov; Vol. 92 (11), pp. 2980-2983. Date of Electronic Publication: 2022 Aug 15.

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Towards the next generation of dual Bcl-2/Bcl-xL inhibitors

Autor: Kate Byth, Daniel John Russell, Jamal Carlos Saeh, Terry MacIntyre, Stephanos Ioannidis, Thomas Gero, Diebold R Bruce, Galina Repik, Paul T. Grover, Ogoe Claude Afona, Mei Su, Jeffrey G. Varnes, Prasenjit Mukherjee, Shan Huang, Keith Dillman

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 24:3026-3033

Structural modifications of the left-hand side of compound 1 were identified which retained or improved potent binding to Bcl-2 and Bcl-xL in in vitro biochemical assays and had strong activity in an RS4;11 apoptotic cellular assay. For example, sulf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f19cec2e34e8552a5681ee019d02c01
https://doi.org/10.1016/j.bmcl.2014.05.036