A deep learning approach to prediction of blood group antigens from genomic data.

Autor: Moslemi C; Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark.; Institute of Science and Environment, Roskilde University, Roskilde, Denmark., Sækmose S; Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark., Larsen R; Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark., Brodersen T; Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark., Bay JT; Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark., Didriksen M; Department of Clinical Immunology, Copenhagen University Hospital, Rigshopitalet, Copenhagen, Denmark., Nielsen KR; Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark., Bruun MT; Department of Clinical Immunology, Odense University Hospital, Odense, Denmark., Dowsett J; Department of Clinical Immunology, Copenhagen University Hospital, Rigshopitalet, Copenhagen, Denmark., Dinh KM; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark., Mikkelsen C; Department of Clinical Immunology, Copenhagen University Hospital, Rigshopitalet, Copenhagen, Denmark., Hyvärinen K; Finnish Red Cross Blood Service, Helsinki, Finland., Ritari J; Finnish Red Cross Blood Service, Helsinki, Finland., Partanen J; Finnish Red Cross Blood Service, Helsinki, Finland., Ullum H; Statens Serum Institut, Copenhagen, Denmark., Erikstrup C; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Ostrowski SR; Department of Clinical Immunology, Copenhagen University Hospital, Rigshopitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Olsson ML; Department of Laboratory Medicine, Lund University, Lund, Sweden.; Department of Clinical Immunology and Transfusion, Office for Medical Services, Region Skåne, Sweden., Pedersen OB; Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Publikováno v: Transfusion [Transfusion] 2024 Nov; Vol. 64 (11), pp. 2179-2195. Date of Electronic Publication: 2024 Sep 13.

Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction.

Autor: Schormair B; Institute of Neurogenomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. barbara.schormair@helmholtz-munich.de.; Institute of Human Genetics, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany. barbara.schormair@helmholtz-munich.de., Zhao C; Institute of Neurogenomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany., Bell S; Department of Oncology, University of Cambridge, Cambridge, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK., Didriksen M; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Department of Neuroscience, University of Copenhagen, Copenhagen, Denmark., Nawaz MS; deCODE Genetics/Amgen, Reykjavik, Iceland., Schandra N; Institute of Neurogenomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany., Stefani A; Sleep Disorders Clinic, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria., Högl B; Sleep Disorders Clinic, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria., Dauvilliers Y; Sleep-Wake Disorders Center, Department of Neurology, Hôpital Gui-de-Chauliac, CHU Montpellier, Institut des Neurosciences de Montpellier, INSERM, Université de Montpellier, Montpellier, France., Bachmann CG; SomnoDiagnostics, Osnabrück, Germany.; Department of Neurology, University Medical Center Göttingen, Göttingen, Germany., Kemlink D; Department of Neurology and Centre of Clinical Neuroscience, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic., Sonka K; Department of Neurology and Centre of Clinical Neuroscience, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic., Paulus W; Department of Neurology, Ludwig Maximilians University Munich, Munich, Germany., Trenkwalder C; Paracelsus-Elena-Klinik, Kassel, Germany.; Department of Neurosurgery, University Medical Center Göttingen, Göttingen, Germany., Oertel WH; Institute of Neurogenomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Department of Neurology, Philipps-University Marburg, Marburg, Germany., Hornyak M; Neuropsychiatry Centre Erding/München, Erding, Germany., Teder-Laving M; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Metspalu A; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Hadjigeorgiou GM; Department of Neurology, Nicosia General Hospital Medical School, University of Cyprus, Nicosia, Cyprus., Polo O; Bragée ME/CFS Center, Stockholm, Sweden., Fietze I; Department of Pulmonology, Center of Sleep Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany., Ross OA; Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA., Wszolek ZK; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Ibrahim A; Sleep Disorders Clinic, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria., Bergmann M; Sleep Disorders Clinic, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria., Kittke V; Institute of Neurogenomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany., Harrer P; Institute of Neurogenomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany., Dowsett J; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Chenini S; Sleep-Wake Disorders Center, Department of Neurology, Hôpital Gui-de-Chauliac, CHU Montpellier, Institut des Neurosciences de Montpellier, INSERM, Université de Montpellier, Montpellier, France., Ostrowski SR; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Sørensen E; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Erikstrup C; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Pedersen OB; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark., Topholm Bruun M; Department of Clinical Immunology, Odense University Hospital, Odense, Denmark., Nielsen KR; Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark., Butterworth AS; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK., Soranzo N; National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Department of Human Genetics, the Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Ouwehand WH; Department of Haematology, University of Cambridge, Cambridge, UK.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, UK.; Department of Haematology, University College London Hospitals, London, UK., Roberts DJ; National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK.; Radcliffe Department of Medicine and National Health Service Blood and Transplant, Oxford, UK.; Department of Haematology and BRC Haematology Theme, Churchill Hospital, Headington, Oxford, UK., Danesh J; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; Department of Human Genetics, the Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Burchell B; Magdalene College, Cambridge, UK., Furlotte NA; 23andMe, Inc., Sunnyvale, CA, USA., Nandakumar P; 23andMe, Inc., Sunnyvale, CA, USA., Earley CJ; Center for Restless Legs Syndrome, Department of Neurology, Johns Hopkins University, Baltimore, MD, USA., Ondo WG; Department of Neurology, Methodist Neurological Institute, Weill Cornell Medical School, Houston, TX, USA., Xiong L; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada., Desautels A; Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal, Montreal, Quebec, Canada.; Department of Neurosciences, Université de Montréal, Montreal, Quebec, Canada., Perola M; Clinical and Molecular Metabolism Research Program (CAMM), Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Department of Public Health and Welfare, National Institute for Health and Welfare, Helsinki, Finland., Vodicka P; Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Science of Czech Republic, Prague, Czech Republic.; First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.; Biomedical Centre, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic., Dina C; L'institut du thorax, CNRS, INSERM, Nantes Université, Nantes, France., Stoll M; Department of Genetic Epidemiology, Institute for Human Genetics, University of Münster, Münster, Germany., Franke A; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany., Lieb W; PopGen Biobank and Institute of Epidemiology, Christian Albrechts University Kiel, Kiel, Germany., Stewart AFR; John and Jennifer Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada., Shah SH; Department of Medicine, Duke University School of Medicine, Durham, NC, USA.; Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA., Gieger C; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Peters A; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Research Center for Cardiovascular Disease (DZHK), partner site Munich Heart Alliance, Hannover, Germany.; Chair of Epidemiology, Institute for Medical Information Processing, Biometry and Epidemiology, Medical Faculty, Ludwig-Maximilians-Universität München, Munich, Germany., Rye DB; Department of Neurology, Emory University, Atlanta, GA, USA., Rouleau GA; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.; Department of Human Genetics, McGill University, Montreal, Quebec, Canada., Berger K; Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany., Stefansson H; deCODE Genetics/Amgen, Reykjavik, Iceland., Ullum H; Statens Serum Institute, Copenhagen, Denmark., Stefansson K; deCODE Genetics/Amgen, Reykjavik, Iceland., Hinds DA; 23andMe, Inc., Sunnyvale, CA, USA., Di Angelantonio E; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; Health Data Science Research Centre, Fondazione Human Technopole, Milan, Italy., Oexle K; Institute of Neurogenomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.; Neurogenetic Systems Analysis Group, Institute of Neurogenomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Winkelmann J; Institute of Neurogenomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; German Center for Mental Health (DZPG), partner site Munich-Augsburg, Munich-Augsburg, Germany.

Publikováno v: Nature genetics [Nat Genet] 2024 Jun; Vol. 56 (6), pp. 1090-1099. Date of Electronic Publication: 2024 Jun 05.

No association between migraine and HLA alleles in a cohort of 13,210 individuals with migraine from the Danish Blood Donor Study.

Autor: Tummoszeit IZ; Danish Headache Center, Department of Neurology, Copenhagen University Hospital, Glostrup, Denmark., Olofsson IA; Danish Headache Center, Department of Neurology, Copenhagen University Hospital, Glostrup, Denmark.; Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Chalmer MA; Danish Headache Center, Department of Neurology, Copenhagen University Hospital, Glostrup, Denmark., Henriksen AP; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Aagaard B; Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark., Brunak S; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Bruun MT; Department of Clinical Immunology, Odense University Hospital, Odense, Denmark., Didriksen M; Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Erikstrup C; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark., Hjalgrim H; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Statens Serum Institut, Copenhagen, Denmark.; Danish Cancer Institute, Copenhagen, Denmark.; Department of Haematology, Copenhagen University Hospital, Copenhagen, Denmark., Mikkelsen C; Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Mikkelsen S; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark., Ostrowski SR; Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Pedersen OBV; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark., Quinn L; Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark., Sørensen E; Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark., Ullum H; Statens Serum Institut, Copenhagen, Denmark., Olesen J; Danish Headache Center, Department of Neurology, Copenhagen University Hospital, Glostrup, Denmark., Banasik K; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Gynecology and Obstetrics, Hvidovre University Hospital, Copenhagen, Denmark., Hansen TF; Danish Headache Center, Department of Neurology, Copenhagen University Hospital, Glostrup, Denmark.; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Kogelman LJA; Danish Headache Center, Department of Neurology, Copenhagen University Hospital, Glostrup, Denmark.; Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.

Publikováno v: Headache [Headache] 2024 Oct 01. Date of Electronic Publication: 2024 Oct 01.

Validity of the Systemizer Profile Questionnaire: A New Tool to Identify Cognitive, Mentalizing, Sensory, Social, and Systemizing Abilities in Adults with Autism-Spectrum-Disorders With and Without Comorbid ADHD.

Autor: Jakobsen KD; Psychiatric Private Practice, Jernbanegade 16, Fredensborg, DK-3480, Denmark. kdjakobsen@gmail.com.; Institute of Biological Psychiatry, Mental Health Centre St. Hans, Mental Health Services of the Capital Region of Copenhagen, Boserupvej 2, DK-4000, Roskilde, Denmark. kdjakobsen@gmail.com., Callesen K; Psychological Resource Centre, Raadhusstraede 6, Copenhagen, DK-1466, Denmark., Larsen EB; Psychiatric Private Practice, Soeborg Hovedgade 199, Soeborg, DK-2860, Denmark., Pedersen OBV; Department of Clinical Immunology, Zealand University Hospital, Ringstedgade 61, Naestved, DK-4700, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Didriksen M; Department of Clinical Immunology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, Copenhagen, DK-2100, Denmark.; Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Ostrowski SR; Department of Clinical Immunology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, Copenhagen, DK-2100, Denmark.; Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Christensen KB; Section of Biostatistics, Department of Public Health, University of Copenhagen, Oester Farimagsgade 5, Copenhagen K, DK-1353, Denmark.

Publikováno v: Journal of autism and developmental disorders [J Autism Dev Disord] 2024 Aug 17. Date of Electronic Publication: 2024 Aug 17.

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