Prion strains associated with iatrogenic CJD in French and UK human growth hormone recipients

Autor: Jean-Yves Douet, Alvina Huor, Hervé Cassard, Séverine Lugan, Naïma Aron, Chloé Mesic, Didier Vilette, Tomás Barrio, Nathalie Streichenberger, Armand Perret-Liaudet, Marie-Bernadette Delisle, Patrice Péran, Jean-Philippe Deslys, Emmanuel Comoy, Jean-Luc Vilotte, Katayoun Goudarzi, Vincent Béringue, Marcelo A. Barria, Diane L. Ritchie, James W. Ironside, Olivier Andréoletti

Publikováno v: Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-15 (2021)

Abstract Treatment with human pituitary-derived growth hormone (hGH) was responsible for a significant proportion of iatrogenic Creutzfeldt–Jakob disease (iCJD) cases. France and the UK experienced the largest case numbers of hGH-iCJD, with 122 and

Externí odkaz: https://doaj.org/article/38331de11f744c59b42002fabad71f84

Preclinical detection of variant CJD and BSE prions in blood.

Autor: Caroline Lacroux, Emmanuel Comoy, Mohammed Moudjou, Armand Perret-Liaudet, Séverine Lugan, Claire Litaise, Hugh Simmons, Christelle Jas-Duval, Isabelle Lantier, Vincent Béringue, Martin Groschup, Guillaume Fichet, Pierrette Costes, Nathalie Streichenberger, Frederic Lantier, Jean Philippe Deslys, Didier Vilette, Olivier Andréoletti

Publikováno v: PLoS Pathogens, Vol 10, Iss 6, p e1004202 (2014)

The emergence of variant Creutzfeldt Jakob Disease (vCJD) is considered a likely consequence of human dietary exposure to Bovine Spongiform Encephalopathy (BSE) agent. More recently, secondary vCJD cases were identified in patients transfused with bl

Externí odkaz: https://doaj.org/article/a37cfeacd0334014b4ea266934ffded8

Highly efficient prion transmission by blood transfusion.

Autor: Olivier Andréoletti, Claire Litaise, Hugh Simmons, Fabien Corbière, Séverine Lugan, Pierrette Costes, François Schelcher, Didier Vilette, Jacques Grassi, Caroline Lacroux

Publikováno v: PLoS Pathogens, Vol 8, Iss 6, p e1002782 (2012)

It is now clearly established that the transfusion of blood from variant CJD (v-CJD) infected individuals can transmit the disease. Since the number of asymptomatic infected donors remains unresolved, inter-individual v-CJD transmission through blood

Externí odkaz: https://doaj.org/article/8b13bf85ef064735baeb078760dc0d0c

Protein folding activity of ribosomal RNA is a selective target of two unrelated antiprion drugs.

Autor: Déborah Tribouillard-Tanvier, Suzana Dos Reis, Fabienne Gug, Cécile Voisset, Vincent Béringue, Raimon Sabate, Ema Kikovska, Nicolas Talarek, Stéphane Bach, Chenhui Huang, Nathalie Desban, Sven J Saupe, Surachai Supattapone, Jean-Yves Thuret, Stéphane Chédin, Didier Vilette, Hervé Galons, Suparna Sanyal, Marc Blondel

Publikováno v: PLoS ONE, Vol 3, Iss 5, p e2174 (2008)

6-Aminophenanthridine (6AP) and Guanabenz (GA, a drug currently in use for the treatment of hypertension) were isolated as antiprion drugs using a yeast-based assay. These structurally unrelated molecules are also active against mammalian prion in se

Externí odkaz: https://doaj.org/article/a5173f705cba426cb60f9b719e0de299

Prions from Sporadic Creutzfeldt-Jakob Disease Patients Propagate as Strain Mixtures

Autor: Alba Marín-Moreno, Séverine Lugan, Patrice Péran, Alvina Huor, James W. Ironside, Juan Carlos Espinosa, Naima Aron, Vincent Béringue, Hervé Cassard, Jean-Yves Douet, Olivier Andreoletti, Marie-Bernadette Delisle, Juan María Torres, Didier Vilette

Publikováno v: mBio
mBio, American Society for Microbiology, 2020, 11 (3), pp.e00393-20. ⟨10.1128/mBio.00393-20⟩
mBio, Vol 11, Iss 3, p e00393-20 (2020)
mBio, 2020, 11 (3), pp.e00393-20. ⟨10.1128/mBio.00393-20⟩
mBio, Vol 11, Iss 3 (2020)
Cassard, H, Huor, A, Espinosa, J-C, Douet, J-Y, Lugan, S, Aron, N, Vilette, D, Delisle, M-B, Marín-Moreno, A, Peran, P, Beringue, V, Torres, J M, Ironside, J W & Andreoletti, O 2020, ' Prions from Sporadic Creutzfeldt-Jakob Disease Patients Propagate as Strain Mixtures ', mBio, vol. 11, no. 3 . https://doi.org/10.1128/mBio.00393-20

sCJD occurrence is currently assumed to result from spontaneous and stochastic formation of a misfolded PrP nucleus in the brains of affected patients. This original nucleus then recruits and converts nascent PrPC into PrPSc, leading to the propagati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b457368135032759566a2d19946dadf7
https://doi.org/10.1128/mbio.00393-20