Zobrazeno 1 - 10
of 218
pro vyhledávání: '"Didier Rognan"'
Autor:
Antoine Jouvenel, Adrien Tassou, Maxime Thouaye, Jérôme Ruel, Myriam Antri, Jean-Philippe Leyris, Aurore Giraudin, Sylvie Mallié, Chamroeum Sar, Lucie Diouloufet, Corinne Sonrier, François Daubeuf, Juliette Bertin, Stacy Alves, Stéphanie Ventéo, Nelly Frossard, Patrick Carroll, Ilana Mechaly, Didier Rognan, Pierre Sokoloff, Radhouane Dallel, Patrick Delmas, Jean Valmier, Cyril Rivat
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Navigating the duality of opioids’ potent analgesia and side effects, including tolerance and hyperalgesia, is a significant challenge in chronic pain management, often prompting hazardous dose escalation to maintain analgesic effects. The
Externí odkaz:
https://doaj.org/article/62199c8ab61a47228dbb08f3a3507de8
Publikováno v:
ACS Central Science, Vol 10, Iss 3, Pp 615-627 (2024)
Externí odkaz:
https://doaj.org/article/0acbdf41c0a8410db8769e33bbfe2c99
Autor:
Elena Shanina, Sakonwan Kuhaudomlarp, Eike Siebs, Felix F. Fuchsberger, Maxime Denis, Priscila da Silva Figueiredo Celestino Gomes, Mads H. Clausen, Peter H. Seeberger, Didier Rognan, Alexander Titz, Anne Imberty, Christoph Rademacher
Publikováno v:
Communications Chemistry, Vol 5, Iss 1, Pp 1-11 (2022)
Carbohydrate–protein interactions are key for cell–cell and host–pathogen recognition, but their hydrophilic nature makes the development of drug-like inhibitors a challenge. Here, screening of fragment libraries identifies metal-binding pharma
Externí odkaz:
https://doaj.org/article/4b306191f31141ed861dba296acb045e
Autor:
Merveille Eguida, Didier Rognan
Publikováno v:
Journal of Cheminformatics, Vol 13, Iss 1, Pp 1-13 (2021)
Abstract Rationalizing the identification of hidden similarities across the repertoire of druggable protein cavities remains a major hurdle to a true proteome-wide structure-based discovery of novel drug candidates. We recently described a new comput
Externí odkaz:
https://doaj.org/article/3b6c0f8b42f341fbbf2ac7c15015ffe3
Autor:
Cyril Rivat, Chamroeun Sar, Ilana Mechaly, Jean-Philippe Leyris, Lucie Diouloufet, Corinne Sonrier, Yann Philipson, Olivier Lucas, Sylvie Mallié, Antoine Jouvenel, Adrien Tassou, Henri Haton, Stéphanie Venteo, Jean-Philippe Pin, Eric Trinquet, Fabienne Charrier-Savournin, Alexandre Mezghrani, Willy Joly, Julie Mion, Martine Schmitt, Alexandre Pattyn, Frédéric Marmigère, Pierre Sokoloff, Patrick Carroll, Didier Rognan, Jean Valmier
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Sensitisation of dorsal root ganglia neurons contributes to neuropathic pain. Here the authors demonstrate the cytokine FL contributes to sensitisation of DRGs via its receptor FLT3 expressed on neurons, and identify a novel FLT3 inhibitor that atten
Externí odkaz:
https://doaj.org/article/87fd7efd827f43ad990381c8a9541b42
Autor:
Maud Bollenbach, Simona Nemska, Patrick Wagner, Guillaume Camelin, François Daubeuf, Adeline Obrecht, Pascal Villa, Didier Rognan, Frédéric Bihel, Jean-Jacques Bourguignon, Martine Schmitt, Nelly Frossard
Publikováno v:
Molecules, Vol 26, Iss 2, p 391 (2021)
Mitogen- and Stress-Activated Kinase 1 (MSK1) is a nuclear kinase, taking part in the activation pathway of the pro-inflammatory transcription factor NF-kB and is demonstrating a therapeutic target potential in inflammatory diseases such as asthma, p
Externí odkaz:
https://doaj.org/article/be77ee75372d43f0ba33a96af0aa47d9
Autor:
Célien Jacquemard, Viet-Khoa Tran-Nguyen, Malgorzata N. Drwal, Didier Rognan, Esther Kellenberger
Publikováno v:
Molecules, Vol 24, Iss 14, p 2610 (2019)
Ligand docking at a protein site can be improved by prioritizing poses by similarity to validated binding modes found in the crystal structures of ligand/protein complexes. The interactions formed in the predicted model are searched in each of the re
Externí odkaz:
https://doaj.org/article/dc0fb0b879ff440c9c405f5299ec41fe
Autor:
Adrien Rousseau, Alastair G McEwen, Pierre Poussin-Courmontagne, Didier Rognan, Yves Nominé, Marie-Christine Rio, Catherine Tomasetto, Fabien Alpy
Publikováno v:
PLoS Biology, Vol 11, Iss 12, p e1001726 (2013)
Tumor necrosis factor (TNF) receptor-associated factor 4 (TRAF4) is frequently overexpressed in carcinomas, suggesting a specific role in cancer. Although TRAF4 protein is predominantly found at tight junctions (TJs) in normal mammary epithelial cell
Externí odkaz:
https://doaj.org/article/b8771cce77cd4992a489c9c52e0fecfd
Autor:
Elisabeth Guillemet, Seav-Ly Tran, Céline Cadot, Didier Rognan, Didier Lereclus, Nalini Ramarao
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55085 (2013)
Bacillus cereus is a Gram-positive spore-forming bacterium causing food poisoning and serious opportunistic infections. These infections are characterized by bacterial accumulation despite the recruitment of phagocytic cells. We have previously shown
Externí odkaz:
https://doaj.org/article/0a14949ee0464f13a965b89b470b1091
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12214 (2010)
Predicting off-targets by computational methods is getting increasing importance in early drug discovery stages. We herewith present a computational method based on binding site three-dimensional comparisons, which prompted us to investigate the cros
Externí odkaz:
https://doaj.org/article/e6e95cd5389c459d8ae6889df416efe5