Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Didier R. Lefebvre"'
Autor:
Axel H. Meyer, Thomas M. Feldsien, Mario Mezler, Christopher Untucht, Ramakrishna Venugopalan, Didier R. Lefebvre
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1100 (2023)
The blood-brain barrier (BBB) is a major hurdle for the development of systemically delivered drugs against diseases of the central nervous system (CNS). Because of this barrier there is still a huge unmet need for the treatment of these diseases, de
Externí odkaz:
https://doaj.org/article/45d3488e046e4470a84c1662b355c574
Autor:
Ghazal Naseri Kouzehgarani, Pankaj Kumar, Susan E. Bolin, Edward B. Reilly, Didier R. Lefebvre
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1441 (2022)
Cerebrospinal fluid (CSF) microcirculation refers to CSF flow through brain or spinal parenchyma. CSF enters the tissue along the perivascular spaces of the penetrating arteries where it mixes with the interstitial fluid circulating through the extra
Externí odkaz:
https://doaj.org/article/4a54b6351d0c4b0d8daf9e39fdb688a2
Autor:
Kendra A Porath, Michael S Regan, Jessica I Griffith, Sonia Jain, Sylwia A Stopka, Danielle M Burgenske, Katrina K Bakken, Brett L Carlson, Paul A Decker, Rachael A Vaubel, Sonja Dragojevic, Ann C Mladek, Margaret A Connors, Zeng Hu, Lihong He, Gaspar J Kitange, Shiv K Gupta, Thomas M Feldsien, Didier R Lefebvre, Nathalie Y R Agar, Jeanette E Eckel-Passow, Edward B Reilly, William F Elmquist, Jann N Sarkaria
Publikováno v:
Neuro-oncology advances. 4(1)
Background EGFR targeting antibody-drug conjugates (ADCs) are highly effective against EGFR-amplified tumors, but poor distribution across the blood–brain barrier (BBB) limits their efficacy in glioblastoma (GBM) when administered systemically. We
Autor:
Kendra A. Porath, Ann Mladek, Rachael A. Vaubel, Michael S. Regan, Sonia Jain, Danielle Burgenske, Katrina Bakken, Brett Carlson, Margaret Connors, Zeng Hu, Lihong He, Paul A. Decker, Gaspar Kitange, Shiv Gupta, Nathalie Y. Agar, Thomas M. Feldsien, Didier R. Lefebvre, Jann N. Sarkaria
Publikováno v:
Cancer Research. 82:334-334
Introduction: EGFR targeted antibody-drug conjugates (ADCs) show promise as a novel treatment in a subset of glioblastoma (GBM). Two EGFR targeting ADCs include first generation Depatux-M, with an antimitotic toxin monomethyl auristatin F (MMAF), and
Autor:
Didier R. Lefebvre, David A. Dillard
Publikováno v:
The Journal of Adhesion. 70:119-138
Since crack initiation in adhesive bonds tends to occur near the interface corners where the stress fields are singular, we define a fatigue initiation criterion using stress singularity parameter, Q (a generalized stress intensity factor) and the si
Publikováno v:
The Journal of Adhesion. 70:139-154
Using the epoxy-aluminum wedge specimens defined and analyzed in Part 1, we measure the number of cycles required to initiate an interfacial fatigue crack near the apex, where the stress field is predicted to be singular. The eigenvalue, λ, and the
Publikováno v:
Journal of Electronic Packaging. 130
A high precision technique for measuring Poisson’s ratios of elastomers was experimentally implemented. Test fixtures consisted of hollow metal cylinders fitted with matching pairs of pressure sensors at the top and bottom. Evaluation of a prelimin
Autor:
Didier R. Lefebvre, Jun Han, John M. Lipari, Michelle A. Long, Rachel L. McSwain, Heidi C. Wells
Publikováno v:
Journal of Applied Polymer Science; Sep2006, Vol. 101 Issue 5, p2765-2775, 11p
Publikováno v:
The Journal of Adhesion. 27:19-40
The concentration dependence and temperature dependence of the diffusion coefficient, as discussed in Part I, are validated with literature data on poly(styrene) and on poly(vinylacetate). The effect on diffusivity, of a uniaxial tensile stress state
Publikováno v:
The Journal of Adhesion. 27:1-18
A methodology is proposed to relate the diffusion coefficient of small penetrant molecules in polymers to temperature, strain, and penetrant concentration. The approach used is based on well-known free volume theories. It is assumed that the transpor