Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Didier Portilla"'
Publikováno v:
Journal of the Formosan Medical Association, Vol 112, Iss 5, Pp 237-243 (2013)
One cornerstone of chronic kidney disease (CKD) is fibrosis, as kidneys are susceptible due to their high vascularity and predisposition to ischemia. Presently, only therapies targeting the angiotensin receptor are used in clinical practice to retard
Externí odkaz:
https://doaj.org/article/f7396833ffa34fe2aa59f08b62c240b5
Folic acid-mediated fibrosis is driven by C5a receptor 1-mediated activation of kidney myeloid cells
Autor:
Ranjit K. Sahu, Sandhya Xavier, Daniel Chauss, Luopin Wang, Claude Chew, Ronald Taylor, William B. Stallcup, Jennie Z. Ma, Majid Kazemian, Behdad Afzali, Jörg Köhl, Didier Portilla
Publikováno v:
Am J Physiol Renal Physiol
We have previously reported that increased expression and activation of kidney cell complement components play an important role in the pathogenesis of renal scarring. Here, we used floxed green fluorescent protein (GFP)-C5a receptor 1 (C5aR1) knocki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::502abd1c605f3688bc9371dfa9aa7989
https://doi.org/10.1152/ajprenal.00404.2021
https://doi.org/10.1152/ajprenal.00404.2021
Autor:
Alexandra F. Freeman, Majid Kazemian, Jack A. Bibby, Daniel Chauss, Daniel S. Chertow, Michail S. Lionakis, Reuben McGregor, Tilo Freiwald, Nehal N. Mehta, Heather L. Teague, Luopin Wang, Audrey Kelly, Behdad Afzali, Estefania Nova-Lamperti, Kevin M. Vannella, Amna Malik, Daniella M. Schwartz, Bingyu Yan, Claudia Kemper, Didier Portilla, Giovanna Lombardi, Marcos J Ramos-Benitez, Susan D. John, Nichola Cooper, Arian Laurence, Paul Lavender, Erin E. West, Zonghao Zhang, Dhaneshwar Kumar
Publikováno v:
Nature immunology
The molecular mechanisms governing orderly shutdown and retraction of CD4+ type 1 helper T (TH1) cell responses remain poorly understood. Here we show that complement triggers contraction of TH1 responses by inducing intrinsic expression of the vitam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6b6f00ceb5d2ec52629d93280aeb2dd
http://europepmc.org/articles/PMC7612139
http://europepmc.org/articles/PMC7612139
Autor:
Sandhya Xavier, Didier Portilla
Publikováno v:
British Journal of Pharmacology. 178:2880-2891
Increased expression of complement C1r, C1s and C3 in kidney cells plays an important role in the pathogenesis of kidney fibrosis. Our studies suggest that activation of complement in kidney cells with increased generation of C3 and its fragments occ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc32f2bd5222dc8fc8a47a192a1b2c95
https://doi.org/10.1111/bph.15408
https://doi.org/10.1111/bph.15408
Autor:
Valentina Loi, Didier Portilla, Sundararaman Swaminathan, Yogesh Scindia, Elizabeth Ghias, Ewa Wlazlo, Sylvia Cechova, Joseph Leeds, Jonathan Ledesma
Publikováno v:
Am J Physiol Renal Physiol
Acute kidney injury (AKI) is a frequent complication of sepsis and an important cause of morbidity and mortality worldwide. A cornerstone of sepsis-associated AKI is dysregulated inflammation, leading to increased tissue oxidative stress and free rad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4e617a29f54807514d6de3ac7dc892d
https://doi.org/10.1152/ajprenal.00064.2020
https://doi.org/10.1152/ajprenal.00064.2020
Autor:
Zhijun Cao, Jennie Z. Ma, Lisa Pence, Devasmita Choudhury, Didier Portilla, Jaclyn R. Daniels, Richard D. Beger, Laura K. Schnackenberg, Li-Rong Yu, Jinchun Sun, Paul M. Palevsky
Publikováno v:
Kidney360
Background: Acute kidney injury requiring dialysis (AKI-D) is associated with prolonged hospitalization, mortality, and progressive chronic kidney disease (CKD) among survivors. Previous studies have examined only select urine or serum biomarkers for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72250553786e4557647c1e4dd4164207
https://pubmed.ncbi.nlm.nih.gov/34913041
https://pubmed.ncbi.nlm.nih.gov/34913041
Autor:
Richard Gregory, Luopin Wang, Nazish Malik, Nathalie Niyonzima, Charles J. Zhang, Jason R. Spence, Sonja Ghidelli-Disse, Matthew R. Olson, Marcus Bantscheff, Stefania Pittaluga, Tristan Frum, Majid Kazemian, Konstantinos D. Alysandratos, Jonathan Z. Sexton, Daniel Chauss, Darrell N. Kotton, Michail S. Lionakis, Carmen Mirabelli, Erin E. West, Didier Portilla, Bingyu Yan, Eva-Maria Nichols, Christiane E. Wobus, Tilo Freiwald, Shahram Kordasti, Martin Kolev, Behdad Afzali, Jack A. Bibby, Arian Laurence, Claudia Kemper
Publikováno v:
Science Immunology. 6
Patients with coronavirus disease 2019 (COVID-19) present a wide range of acute clinical manifestations affecting the lungs, liver, kidneys and gut. Angiotensin converting enzyme (ACE) 2, the best-characterized entry receptor for the disease-causing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2aa12e1c8d7eebe7b873f5801d4418b5
https://doi.org/10.1126/sciimmunol.abg0833
https://doi.org/10.1126/sciimmunol.abg0833
Autor:
Daniel C Chauss, Tilo Freiwald, Reuben McGregor, Bingyu Yan, Luopin Wang, Estafania Nova-Lamperti, Dhaneshwar Kumar, Zonghao Zhang, Heather Teague, Erin West, Kevin M Vannella, Marcos J Ramos-Benitez, Jack Bibby, Audrey Kelly, Amna Malik, Alexandra F Freeman, Daniella M Schwartz, Didier Portilla, Daniel S Chertow, Susan John, Paul Lavender, Claudia Kemper, Giovanna Lombardi, Nehal N Mehta, Nichola Cooper, Michail S Lionakis, Arian Laurence, Majid Kazemian, Behdad Afzali
Publikováno v:
The Journal of Immunology. 208:56.10-56.10
Background Pro-inflammatory CD4+ T helper (Th)1 cells clear pathogens effectively but cause excessive tissue injury if not shut down appropriately. The complement (C’) system both induces Th1 differentiation and their shutdown, but the mechanisms r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2098536ebe576a1470bb4c8b9a2b3c75
https://doi.org/10.4049/jimmunol.208.supp.56.10
https://doi.org/10.4049/jimmunol.208.supp.56.10
Autor:
Heather L. Teague, Susan D. John, Alexandra F. Freeman, Michail S. Lionakis, Paul Lavender, Audrey Kelly, Claudia Kemper, Daniella M. Schwartz, Bingyu Yan, Amna Malik, Jack A. Bibby, Luopin Wang, Daniel Chauss, Nichola Cooper, Estefania Nova-Lamperti, Zonghao Zhang, Tilo Freiwald, Didier Portilla, Giovanna Lombardi, Erin E. West, Behdad Afzali, Arian Laurence, Nehal N. Mehta, Majid Kazemian, Reuben McGregor
Publikováno v:
bioRxiv
Pro-inflammatory immune responses are necessary for effective pathogen clearance, but cause severe tissue damage if not shut down in a timely manner1,2. Excessive complement and IFN-γ-associated responses are known drivers of immunopathogenesis3 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::014af295866fa83a0164e211b25c7d2d
https://pubmed.ncbi.nlm.nih.gov/32743590
https://pubmed.ncbi.nlm.nih.gov/32743590
Autor:
Arian Laurence, Shahram Kordasti, Matthew R. Olson, Didier Portilla, Daniel Chauss, Luopin Wang, Claudia Kemper, Majid Kazemian, Michail S. Lionakis, Jack A. Bibby, Bingyu Yan, Erin E. West, Behdad Afzali, Tilo Freiwald
Publikováno v:
Research Square
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
Patients with coronavirus disease 2019 (COVID-19) present with a range of devastating acute clinical manifestations affecting the lungs, liver, kidneys and gut. The best-characterized entry receptor for the disease-causing virus SARS-CoV2, angiotensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20f43b68cad15da519435e3da9db04f6
http://europepmc.org/articles/PMC7336704
http://europepmc.org/articles/PMC7336704