Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Didier Molko"'
Publikováno v:
Chemical Research in Toxicology. 11:1169-1175
Adenine N1-oxide is a DNA lesion whose formation involves the specific oxidation of the adenine base by hydrogen peroxide under nonradical conditions. The damage may be measured using a HPLC/32P-postlabeling method, which however cannot be used for r
Publikováno v:
The Journal of Organic Chemistry. 63:5245-5249
Publikováno v:
Tetrahedron Letters. 38:7531-7534
Oligonucleotides containing 5-hydroxy-2′-deoxycytidine ( 2 ) have been synthesized using the phosphoramidite chemistry. The presence and the integrity of the modified nucleoside in the synthetic oligomers were confirmed by electrospray mass spectro
Publikováno v:
Journal de Chimie Physique. 94:313-317
L'adenine-N1-oxyde est une lesion de l'ADN resultant de l'effet indirect du rayonnement solaire par action du peroxyde d'hydrogene sur l'adenine. Son dosage dans l'ADN, jusqu'ici obtenu par la methode du post-marquage radioactif etait long et fastidi
Publikováno v:
Free Radical Research. 20:315-325
The ozone-mediated oxidation of thymidine was investigated on the basis of final product identification. The oxidation reaction gave rise to five major modified nucleosides which were isolated and characterised from extensive 1H NMR and mass spectrom
Publikováno v:
Journal de Chimie Physique. 90:863-870
Les reactions d'oxydation de la thymidine, une des bases pyrinmidiniques, par l'ozone en solution aqueuse sont presentees. La caracterisation des produits isoles a permis de montrer que, par comparaison avec l'action des radicaux hydroxyles sur la th
Publikováno v:
Collection of Czechoslovak Chemical Communications. 58:75-78
Publikováno v:
ChemInform. 30
Oligodeoxynucleotides containing the two 5′R and 5′S diastereoisomers of 5′,8-cyclo-2′-deoxyadenosine (CyclodAdo) and 5′,8-cyclo-2′-deoxyguanosine (CyclodGuo) have been synthesized using the phosphoramidite chemistry. The structural assig
Publikováno v:
Nucleosides and Nucleotides. 18:1331-1333
Oligodeoxynucleotides containing the two 5′R and 5′S diastereoisomers of 5′,8-cyclo-2′-deoxyadenosine (CyclodAdo) and 5′,8-cyclo-2′-deoxyguanosine (CyclodGuo) have been synthesized using the phosphoramidite chemistry. The structural assig
Publikováno v:
Nucleosides and Nucleotides. 9:1087-1098
Several N,N-dialkylamlno-cyanoethyl-phosphoroamidites were tested for use in solid-phase synthesis of homo-uridine RNA fragments. N-ethyl-N-me-thylamino protection gave the best results. The corresponding monomer is stable for several months and an a