Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Didier Le Roy"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Preclinical mouse models are critical for understanding the pathophysiological response to infections and developing treatment strategies for sepsis. In keeping with ethical values, researchers follow guidelines to minimize the suffering of
Externí odkaz:
https://doaj.org/article/29691237f9334e90a6f4d31ecf388e54
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/f29a16b67e354099b5b9e6344e5a8f50
Autor:
Irene T. Schrijver, Jacobus Herderschee, Charlotte Théroude, Antonios Kritikos, Guus Leijte, Didier Le Roy, Maelick Brochut, Jean-Daniel Chiche, Matthieu Perreau, Giuseppe Pantaleo, Benoit Guery, Matthijs Kox, Peter Pickkers, Thierry Calandra, Thierry Roger
Publikováno v:
Cells, Vol 13, Iss 4, p 314 (2024)
Patients admitted to the intensive care unit (ICU) often experience endotoxemia, nosocomial infections and sepsis. Polymorphonuclear and monocytic myeloid-derived suppressor cells (PMN-MDSCs and M-MDSCs) can have an important impact on the developmen
Externí odkaz:
https://doaj.org/article/5560237ed9374a99b3cb2b4c03d7f75f
Autor:
Charlotte Théroude, Marta Reverte, Tytti Heinonen, Eleonora Ciarlo, Irene T. Schrijver, Nikolaos Antonakos, Nicolas Maillard, Florian Pralong, Didier Le Roy, Thierry Roger
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Trained immunity refers to the ability of the innate immune system exposed to a first challenge to provide an enhanced response to a secondary homologous or heterologous challenge. We reported that training induced with β-glucan one week before infe
Externí odkaz:
https://doaj.org/article/2b5ed9c435204569ae3f45b8e9d027a1
Autor:
Eleonora Ciarlo, Tytti Heinonen, Jérôme Lugrin, Hans Acha-Orbea, Didier Le Roy, Johan Auwerx, Thierry Roger
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Sirtuin 3 (SIRT3) is the main mitochondrial deacetylase. SIRT3 regulates cell metabolism and redox homeostasis, and protects from aging and age-associated pathologies. SIRT3 may drive both oncogenic and tumor-suppressive effects. SIRT3 defic
Externí odkaz:
https://doaj.org/article/bc479b495c564277aaaa4232ca0847e2
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Sirtuin 2 (SIRT2) and SIRT3 are cytoplasmic and mitochondrial NAD-dependent deacetylases. SIRT2 and SIRT3 target proteins involved in metabolic, proliferation and inflammation pathways and have been implicated in the pathogenesis of neurodegenerative
Externí odkaz:
https://doaj.org/article/c00dec5f985d45ad84d31ab91ee37ab6
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The sirtuins SIRT3 and SIRT5 are the main mitochondrial lysine deacetylase and desuccinylase, respectively. SIRT3 and SIRT5 regulate metabolism and redox homeostasis and have been involved in age-associated metabolic, neurologic and oncologic disease
Externí odkaz:
https://doaj.org/article/f47c12dd049841719cdaa15fc7b9bc89
Autor:
Tytti Heinonen, Eleonora Ciarlo, Charlotte Théroude, Aimilia Pelekanou, Jacobus Herderschee, Didier Le Roy, Thierry Roger
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Sirtuin 5 (SIRT5) is a member of the family of NAD+-dependent lysine/histone deacetylases. SIRT5 resides mainly in the mitochondria where it catalyzes deacetylation, demalonylation, desuccinylation, and deglutarylation of lysine to regulate metabolic
Externí odkaz:
https://doaj.org/article/c0cb66ed02f447b99cec68aae4889a49
Autor:
Eleonora Ciarlo, Tytti Heinonen, Charlotte Théroude, Jacobus Herderschee, Matteo Mombelli, Jérôme Lugrin, Marc Pfefferlé, Beatrice Tyrrell, Sarah Lensch, Hans Acha-Orbea, Didier Le Roy, Johan Auwerx, Thierry Roger
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Sirtuin 2 (SIRT2) is one of the seven members of the family of NAD+-dependent histone deacetylases. Sirtuins target histones and non-histone proteins according to their subcellular localization, influencing various biological processes. SIRT2 resides
Externí odkaz:
https://doaj.org/article/b0cfa00f1243495f8bf99759e3e50e8e
Autor:
Mathieu Heulot, Nicolas Jacquier, Sébastien Aeby, Didier Le Roy, Thierry Roger, Evgeniya Trofimenko, David Barras, Gilbert Greub, Christian Widmann
Publikováno v:
Frontiers in Microbiology, Vol 8 (2017)
Antibiotic resistance has become a major health issue. Nosocomial infections and the prevalence of resistant pathogenic bacterial strains are rising steadily. Therefore, there is an urgent need to develop new classes of antibiotics effective on multi
Externí odkaz:
https://doaj.org/article/a5e8ec2d2c2a477080ae6375948120ff