Zobrazeno 1 - 10
of 170
pro vyhledávání: '"Didier Lardinois"'
Autor:
Marcel P. Trefny, Nicole Kirchhammer, Priska Auf der Maur, Marina Natoli, Dominic Schmid, Markus Germann, Laura Fernandez Rodriguez, Petra Herzig, Jonas Lötscher, Maryam Akrami, Jane C. Stinchcombe, Michal A. Stanczak, Andreas Zingg, Melanie Buchi, Julien Roux, Romina Marone, Leyla Don, Didier Lardinois, Mark Wiese, Lukas T. Jeker, Mohamed Bentires-Alj, Jérémie Rossy, Daniela S. Thommen, Gillian M. Griffiths, Heinz Läubli, Christoph Hess, Alfred Zippelius
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
The efficacy of T-cell-based cancer immunotherapies can be compromised by T cell exhaustion. Here the authors develop a human ex vivo exhaustion model and, based on a CRISPR-Cas9 screen, identify SNX9 as a regulator of T cell exhaustion, showing that
Externí odkaz:
https://doaj.org/article/fdf4b11832574e5fbfe57578d57e0309
Autor:
Alfred Zippelius, Petra Herzig, Pratiksha Gulati, Christian Klein, Marta Trüb, Kirsten D Mertz, Robert Rosenberg, Viola Heinzelmann-Schwarz, Mark Wiese, Didier Lardinois, Pablo Umana, Marina Natoli, Klas Hatje, Fabian Junker, Zhiwen Jiang, Iakov I Davydov, Markus Germann, Daniel Marbach, Adrian Zwick, Patrick Weber, Stefan Seeber, Lothar Tietze, Laura Codarri-Deak, Henry Kao
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 11 (2022)
Background Next-generation cancer immunotherapies are designed to broaden the therapeutic repertoire by targeting new immune checkpoints including lymphocyte-activation gene 3 (LAG-3) and T cell immunoglobulin and mucin-domain containing-3 (TIM-3). Y
Externí odkaz:
https://doaj.org/article/d05c988c40044c0488968cfb22947d69
Publikováno v:
Breathe, Vol 14, Iss 4, Pp 302-310 (2018)
The widely accepted and still increasing use of video-assisted thoracic surgery (VATS) in pleuro-pulmonary pathology imposes the need to deal with two major pitfalls: the first is to avoid its unselective use, while the second relates to inappropriat
Externí odkaz:
https://doaj.org/article/84d54b0754e941a38604a1ade7a60289
Autor:
Alfred Zippelius, Petra Herzig, Heinz Läubli, Gieri Cathomas, Christian Klein, Marta Trüb, Franziska Uhlenbrock, Christina Claus, Martin Thelen, Marina Bacac, Maria Amann, Rosemarie Albrecht, Claudia Ferrara-Koller, Daniela Thommen, Sacha Rothschield, Spasenija Savic Prince, Kirsten D Mertz, Robert Rosenberg, Viola Heinzelmann-Schwarz, Mark Wiese, Didier Lardinois, Pablo Umana, Abhishek S Kashyap
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background The costimulatory receptor 4-1BB (CD137, TNFRSF9) plays an important role in sustaining effective T cell immune responses and is investigated as target for cancer therapy. Systemic 4-1BB directed therapies elicit toxicity or low efficacy,
Externí odkaz:
https://doaj.org/article/812e0e185e314e829d4e8fe6aa67b3da
Publikováno v:
Case Reports in Surgery, Vol 2019 (2019)
Several technical points for postoperative lung hernia repair are still not fully elucidated. We present an original technical solution to deal with this complication. In a 68-year-old female, the lung hernia was confirmed 5 months after the partial
Externí odkaz:
https://doaj.org/article/29703f082e4e474789f3ab8d0924dec3
Autor:
Heinz Läubli, Viktor H. Koelzer, Matthias S. Matter, Petra Herzig, Béatrice Dolder Schlienger, Mark Nikolaj Wiese, Didier Lardinois, Kirsten D. Mertz, Alfred Zippelius
Publikováno v:
OncoImmunology, Vol 7, Iss 2 (2018)
Cancer immunotherapy with antibodies targeting immune checkpoints such as the PD-1/PD-L1 pathway have emerged as breakthrough treatment for multiple solid tumors with high response rates and durable remissions. Despite the benefit for patients and en
Externí odkaz:
https://doaj.org/article/798022384f2747deb8d7739f4959e7ed
Autor:
Katrin E Hostettler, Amiq Gazdhar, Petra Khan, Spasenija Savic, Luca Tamo, Didier Lardinois, Michael Roth, Michael Tamm, Thomas Geiser
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0181946 (2017)
Stem cells have been identified in the human lung; however, their role in lung disease is not clear. We aimed to isolate mesenchymal stem cells (MSC) from human lung tissue and to study their in vitro properties.MSC were cultured from lung tissue obt
Externí odkaz:
https://doaj.org/article/bb622879892c40eea8bc033e274c88d3
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0136549 (2015)
Airway wall remodeling in allergic asthma is reduced after treatment with humanized anti-IgE-antibodies. We reported earlier that purified IgE, without the presence of allergens, is sufficient to induce airway wall remodeling due to airway smooth mus
Externí odkaz:
https://doaj.org/article/9cded544ffea4871a5e299353578d2f7
Autor:
Laura Keglowich, Michael Roth, Maria Philippova, Thérèse Resink, Gavin Tjin, Brian Oliver, Didier Lardinois, Sophie Dessus-Babus, Reinoud Gosens, Katrin Hostettler Haack, Michael Tamm, Peter Borger
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e81494 (2013)
BackgroundAirway wall remodelling is a key pathology of asthma. It includes thickening of the airway wall, hypertrophy and hyperplasia of bronchial smooth muscle cells (BSMC), as well as an increased vascularity of the sub-epithelial cell layer. BSMC
Externí odkaz:
https://doaj.org/article/bdd7199be21c434f8aa214c3432b9e59
Autor:
Alfred Zippelius, Didier Lardinois, Vaios Karanikas, Victor Levitsky, Spasenija Savic Prince, Wolfgang Moersig, Ozana S. Fischer, Marina Bacac, Christian Klein, Pavel Pisa, Pablo Umana, Anton Belousov, Andreas Roller, Petra Herzig, Philipp Müller, Jens Schreiner, Daniela S. Thommen
Dysfunctional T cells present in malignant lesions are characterized by a sustained and highly diverse expression of inhibitory receptors, also referred to as immune checkpoints. Yet, their relative functional significance in different cancer types r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dec2145384c4a5a58e14f99be122a0c0
https://doi.org/10.1158/2326-6066.c.6548741.v1
https://doi.org/10.1158/2326-6066.c.6548741.v1