Zobrazeno 1 - 10 of 32 pro vyhledávání: '"Didier Gagne"'
1
The novel nonapeptide acein targets angiotensin converting enzyme in the brain and induces dopamine release
Autor: Sonia Cantel, Philippe Marin, Jean-Louis Banères, Gilbert Bergé, Karine Puget, Jean Martinez, Charlène Valmalle, Gilles Subra, Anne-Claire Coyne, Céline M'Kadmi, Jérémie Neasta, Jean-Claude Galleyrand, Valérie Daugé, Nicole Bernad, Jacky Marie, Didier Gagne, Eric Carnazzi, Marie-Lou Kemel
Publikováno v: British Journal of Pharmacology. 173:1314-1328
Background and PurposeUsing an in-house bioinformatics programme, we identified and synthesized a novel nonapeptide, H-Pro-Pro-Thr-Thr-Thr-Lys-Phe-Ala-Ala-OH. Here, we have studied its biological activity, in vitro and in vivo, and have identified it
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::829dd5940fe449315393140624d7c64c
https://doi.org/10.1111/bph.13424
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2
Selenazolidine: a selenium containing proline surrogate in peptide science
Autor: Gilles Subra, Jean Martinez, Sonia Cantel, Didier Gagne, Aurélien Lebrun, Christine Enjalbal, Emmanuelle Cordeau
Publikováno v: Organic & Biomolecular Chemistry. 14:8101-8108
In the search for new peptide ligands containing selenium in their sequences, we investigated l-4-selenazolidine-carboxylic acid (selenazolidine, Sez) as a proline analog with the chalcogen atom in the γ-position of the ring. In contrast to proteino
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e832012050352902dd91064e267f756a
https://doi.org/10.1039/c6ob01450j
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3
GHSR-D2R heteromerization modulates dopamine signaling through an effect on G protein conformation
Autor: Maxime Louet, Khoubaib Ben Haj Salah, Céline M'Kadmi, Ali Kaya, Jean-Alain Fehrentz, Lucie Hartmann, Didier Gagne, Véronique Pons, Pedro Renault, Séverine Denoyelle, Sophie Mary, Renaud Wagner, Jacky Marie, Gilles Ferry, Céline Galés, Marjorie Damian, Jean-Louis Banères, Heidi E. Hamm, Jean Martinez, Bartholomé Delort, Jean A. Boutin, Nicolas Floquet
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2018, 115 (17), pp.4501-4506. ⟨10.1073/pnas.1712725115⟩
The growth hormone secretagogue receptor (GHSR) and dopamine receptor (D2R) have been shown to oligomerize in hypothalamic neurons with a significant effect on dopamine signaling, but the molecular processes underlying this effect are still obscure.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeb0971c451af133a6524f9bace79bd7
https://hal.archives-ouvertes.fr/hal-02322168
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6
Quantitative MALDI-MS Binding Assays: An Alternative to Radiolabeling
Autor: Guillaume Miralles, Maxime Rossato, Didier Gagne, Mathieu Maingot, Bernard Mouillac, Muriel Amblard, Céline M'Kadmi, Gilles Subra, Christine Enjalbal, Sonia Cantel, Jean Martinez
Publikováno v: ChemMedChem
ChemMedChem, 2016, 11 (23), pp.2582-2587. ⟨10.1002/cmdc.201600447⟩
International audience; Radiolabeling of ligands is still the gold standard in the study of high-affinity receptor-ligand interactions. In an effort toward safer and simpler alternatives to the use of radioisotopes, we developed a quantitative and hi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::135c5b7ac36dcda26b8032702a21eab6
https://pubmed.ncbi.nlm.nih.gov/27922213
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7
New ligands of the ghrelin receptor based on the 1,2,4-triazole scaffold by introduction of a second chiral center
Autor: Jean Martinez, Babette Aicher, Peter Schmidt, Jacky Marie, Jean-Louis Banères, Gilbert Müller, Sophie Mary, Anne-Laure Blayo, Didier Gagne, Séverine Denoyelle, Eckhard Günther, Mathieu Maingot, Michael Teifel, Céline M'Kadmi, Jean-Alain Fehrentz, Marjorie Damian, Pierre Sanchez
Publikováno v: Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2016, 26 (10), pp.2408-2412. ⟨10.1016/j.bmcl.2016.04.003⟩
Introducing a second chiral center on our previously described 1,2,4-triazole, allowed us to increase diversity and elongate the 'C-terminal part' of the molecule. Therefore, we were able to explore mimics of the substance P analogs described as inve
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2453d99aed9b729a5b8511691d7dca67
https://hal.archives-ouvertes.fr/hal-02871896
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8
Selective homodimerization of unprotected peptides using hybrid hydroxydimethylsilane derivatives
Autor: Muriel Amblard, Jean Martinez, Gilles Subra, Jacky Marie, Aurélien Lebrun, Jean-Alain Fehrentz, Ahmad Mehdi, Didier Gagne, Jeremie Ciccione, Cécile Echalier, Aleksandra Kalistratova, Baptiste Legrand, Emilia Naydenova
Publikováno v: RSC Advances
RSC Advances, Royal Society of Chemistry, 2016, ⟨10.1039/c6ra06075g⟩
We developed a simple and straightforward way to dimerize unprotected peptide sequences that relies on a chemoselective condensation of hybrid peptides bearing a hydroxydimethylsilyl group at a chosen position (either C-ter, N-ter or side-chain linke
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d3ef417f7acc3839a92462d3fbaac29
https://hal.archives-ouvertes.fr/hal-01345976
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9
Synthesis and Pharmacological in Vitro and in Vivo Evaluations of Novel Triazole Derivatives as Ligands of the Ghrelin Receptor. 1
Autor: Didier Gagne, Antonio Torsello, Aline Moulin, Jean Claude Galleyrand, Jean-Alain Fehrentz, Delphine Mousseaux, Daniel Perrissoud, Annie Heitz, Luc Demange, Damien Boeglin, Vittorio Locatelli, Jean Martinez, Gilbert Bergé, Joanne Ryan
Publikováno v: Journal of Medicinal Chemistry. 50:1939-1957
A new series of growth hormone secretagogue (GHS) analogues based on the 1,2,4-triazole structure were synthesized and evaluated for their in vitro binding and their ability to stimulate intracellular calcium release to the cloned hGHS-1a ghrelin rec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::117e0b6f6a59fc4f8a033f8f7d84d2c2
https://doi.org/10.1021/jm070024h
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10
Agonism, Antagonism, and Inverse Agonism Bias at the Ghrelin Receptor Signaling
Autor: Jean-Louis Banères, Lauriane Onfroy, Jean-Philippe Leyris, Mathieu Maingot, Pascal Verdié, Jean Martinez, Aude Saulière, Céline Galés, Marjorie Damian, Jean-Alain Fehrentz, Céline M'Kadmi, Didier Gagne, Séverine Denoyelle, Jacky Marie, Sophie Mary
Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, 2015, 290 (45), pp.27021-27039. ⟨10.1074/jbc.M115.659250⟩
International audience; The G protein-coupled receptor GHS-R1a mediates ghrelin-induced growth hormone secretion, food intake, and reward-seeking behaviors. GHS-R1a signals through Gq, Gi/o, G13, and arrestin. Biasing GHS-R1a signaling with specific
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c4d0d6af27d5751b836d84dcea5c49e
https://hal.umontpellier.fr/hal-03564155/document
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