CCDC69 maintains genome integrity by regulating KIF2C/MCAK depolymerase activity and the stability of the chromosomal passenger complex

Autor: Didier Fesquet, Gabriel Rabeharivelo, Juliette van Dijk, Claude Prigent, Nathalie Morin, Sylvie Rouquier

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-20 (2024)

Abstract Accurate genome inheritance during cell division relies on a complex chromosome segregation mechanism. This process occurs once all the kinetochores of sister chromatids are attached to microtubules emanating from the opposite poles of the m

Externí odkaz: https://doaj.org/article/cf0e609755854824bd79682c78e9e60f

SHED-Dependent Oncogenic Signaling of the PEAK3 Pseudo-Kinase

Autor: Youcef Ounoughene, Elise Fourgous, Yvan Boublik, Estelle Saland, Nathan Guiraud, Christian Recher, Serge Urbach, Philippe Fort, Jean-Emmanuel Sarry, Didier Fesquet, Serge Roche

Publikováno v: Cancers; Volume 13; Issue 24; Pages: 6344
Cancers
Cancers, MDPI, 2021, 13 (24), pp.6344. ⟨10.3390/cancers13246344⟩
Cancers, Vol 13, Iss 6344, p 6344 (2021)
Cancers, 2021, 13 (24), pp.6344. ⟨10.3390/cancers13246344⟩

Simple Summary The human kinome is composed of about 50 pseudo-kinases with unclear function, because they are predicted to be catalytically inactive; however, they are shown to play an important role in cancer, similar to active kinases. Understandi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d316c19563527e597840a4384ce9653

The 20S proteasome activator PA28γ controls the compaction of chromatin

Autor: Véronique Baldin, Cristina Vigano, Didier Fesquet, Catherine Bonne-Andrea, Francisca Mechali, Séverine Boulon, Olivier Coux, David Llères, Charlotte Grimaud

Publikováno v: Journal of Cell Science
Journal of Cell Science, Company of Biologists, 2021, 134 (3), ⟨10.1242/jcs.257717⟩

PA28γ (also known as PSME3), a nuclear activator of the 20S proteasome, is involved in the degradation of several proteins regulating cell growth and proliferation and in the dynamics of various nuclear bodies, but its precise cellular functions rem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de000261a7fbd4a1bba840f73351bc40
https://hal.umontpellier.fr/hal-03428214/document

PIP30/FAM192A is a novel regulator of the nuclear proteasome activator PA28γ

Autor: Didier Fesquet, Prisca Boisguerin, Philippe Fort, Corinne Henriquet, Francisca Mechali, Catherine Bonne-Andrea, Véronique Baldin, Séverine Boulon, Thomas Menneteau, Martine Pugnière, Manuelle Ducoux-Petit, Beata Jonik-Nowak, Bertrand Fabre, Olivier Coux, Angus I. Lamond, Odile Burlet-Schiltz, Sylvain de Rossi, Marie-Pierre Bousquet

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (28), pp.E6477-E6486. ⟨10.1073/pnas.1722299115⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2018, 115 (28), pp.E6477-E6486. ⟨10.1073/pnas.1722299115⟩

Significance The 20S proteasome is a key actor of the control of protein levels and integrity in cells. To perform its multiple functions, it works with a series of regulators, among which is a nuclear complex called PA28γ. In particular, PA28γ par

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b58ae2fd3f316304d7821d2f6e57eff
https://hal.science/hal-02267210/file/E6477.full.pdf

NMR Solution Structure of Mob1, a Mitotic Exit Network Protein and its Interaction with an NDR Kinase Peptide

Autor: Didier Fesquet, Andrey V. Kajava, Christian Dumas, André Padilla, Luc Ponchon

Publikováno v: Journal of Molecular Biology. 337:167-182

Proteins of the Mob1/phocein family are found in all eukaryotic cells. In yeast, they are activating subunits of Dbf2-related protein kinases involved in cell cycle control. Despite the wide occurrence of these proteins, their biological functions re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4afe2d258082cf2dfcd5e44b3a2a4d22
https://doi.org/10.1016/j.jmb.2004.01.010