Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Didier Dulon"'
Autor:
Jean-Christophe Leclère, Didier Dulon
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Humans have six members of the ferlin protein family: dysferlin, myoferlin, otoferlin, fer1L4, fer1L5, and fer1L6. These proteins share common features such as multiple Ca2+-binding C2 domains, FerA domains, and membrane anchoring through their singl
Externí odkaz:
https://doaj.org/article/8593ed3d92964b48bc0c8247b2b1a80f
Autor:
Charlotte Calvet, Thibault Peineau, Najate Benamer, Maxence Cornille, Andrea Lelli, Baptiste Plion, Ghizlène Lahlou, Julia Fanchette, Sylvie Nouaille, Jacques Boutet de Monvel, Amrit Estivalet, Philippe Jean, Vincent Michel, Martin Sachse, Nicolas Michalski, Paul Avan, Christine Petit, Didier Dulon, Saaid Safieddine
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105628- (2022)
Summary: Hearing depends on fast and sustained calcium-dependent synaptic vesicle fusion at the ribbon synapses of cochlear inner hair cells (IHCs). The implication of the canonical neuronal SNARE complex in this exocytotic process has so far remaine
Externí odkaz:
https://doaj.org/article/b93b8ca16eb54c7397c900ea371497c5
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11863 (2023)
Hyperacusis, i.e., an increased sensitivity to sounds, is described in several neurodevelopmental disorders (NDDs), including Fragile X Syndrome (FXS). The mechanisms underlying hyperacusis in FXS are still largely unknown and effective therapies are
Externí odkaz:
https://doaj.org/article/0e9673621d364be1a5e418eb9d91daf0
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Age-related hidden hearing loss is often described as a cochlear synaptopathy that results from a progressive degeneration of the inner hair cell (IHC) ribbon synapses. The functional changes occurring at these synapses during aging are not fully und
Externí odkaz:
https://doaj.org/article/ac5ee15ad9b1487d86608b123f07126e
Autor:
Lucy A Dunbar, Pranav Patni, Carlos Aguilar, Philomena Mburu, Laura Corns, Helena RR Wells, Sedigheh Delmaghani, Andrew Parker, Stuart Johnson, Debbie Williams, Christopher T Esapa, Michelle M Simon, Lauren Chessum, Sherylanne Newton, Joanne Dorning, Prashanthini Jeyarajan, Susan Morse, Andrea Lelli, Gemma F Codner, Thibault Peineau, Suhasini R Gopal, Kumar N Alagramam, Ronna Hertzano, Didier Dulon, Sara Wells, Frances M Williams, Christine Petit, Sally J Dawson, Steve DM Brown, Walter Marcotti, Aziz El‐Amraoui, Michael R Bowl
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 9, Pp n/a-n/a (2019)
Abstract Hearing relies on mechanically gated ion channels present in the actin‐rich stereocilia bundles at the apical surface of cochlear hair cells. Our knowledge of the mechanisms underlying the formation and maintenance of the sound‐receptive
Externí odkaz:
https://doaj.org/article/aa32f3d7e38046868ba58a51eb9e8d12
Autor:
Philippe F.Y. Vincent, Soyoun Cho, Margot Tertrais, Yohan Bouleau, Henrique von Gersdorff, Didier Dulon
Publikováno v:
Cell Reports, Vol 25, Iss 12, Pp 3451-3464.e3 (2018)
Summary: A Ca2+ current transient block (ICaTB) by protons occurs at some ribbon-type synapses after exocytosis, but this has not been observed at mammalian hair cells. Here we show that a robust ICaTB occurs at post-hearing mouse and gerbil inner ha
Externí odkaz:
https://doaj.org/article/70812dc1c6a64df6b033b6d258261cf8
Autor:
Nicolas Michalski, Juan D Goutman, Sarah Marie Auclair, Jacques Boutet de Monvel, Margot Tertrais, Alice Emptoz, Alexandre Parrin, Sylvie Nouaille, Marc Guillon, Martin Sachse, Danica Ciric, Amel Bahloul, Jean-Pierre Hardelin, Roger Bryan Sutton, Paul Avan, Shyam S Krishnakumar, James E Rothman, Didier Dulon, Saaid Safieddine, Christine Petit
Publikováno v:
eLife, Vol 6 (2017)
Hearing relies on rapid, temporally precise, and sustained neurotransmitter release at the ribbon synapses of sensory cells, the inner hair cells (IHCs). This process requires otoferlin, a six C2-domain, Ca2+-binding transmembrane protein of synaptic
Externí odkaz:
https://doaj.org/article/0573827227564a46bbf876f5400e53e1
Publikováno v:
eLife, Vol 4 (2015)
We show that a cage-shaped F-actin network is essential for maintaining a tight spatial organization of Cav1.3 Ca2+ channels at the synaptic ribbons of auditory inner hair cells. This F-actin network is also found to provide mechanosensitivity to the
Externí odkaz:
https://doaj.org/article/d2dc8032c0814d8796d5539d1a3a64aa
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25714 (2011)
Auditory hair cells (HCs) have the remarkable property to indefinitely sustain high rates of synaptic vesicle release during ongoing sound stimulation. The mechanisms of vesicle supply that allow such indefatigable exocytosis at the ribbon active zon
Externí odkaz:
https://doaj.org/article/e05f0abe1d454a6084a246c1f4eacfed
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Age-related hidden hearing loss is often described as a cochlear synaptopathy that results from a progressive degeneration of the inner hair cell (IHC) ribbon synapses. The functional changes occurring at these synapses during aging are not fully und