Zobrazeno 1 - 10
of 339
pro vyhledávání: '"Didier, Trono"'
Autor:
Nikolaos M. R. Lykoskoufis, Evarist Planet, Halit Ongen, Didier Trono, Emmanouil T. Dermitzakis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Transposable elements (TEs) are prevalent repeats in the human genome, play a significant role in the regulome, and their disruption can contribute to tumorigenesis. However, TE influence on gene expression in cancer remains unclear. Here, w
Externí odkaz:
https://doaj.org/article/751f2c122b234bc69f931cf20a362f13
Autor:
Norman Moullan, Josephat Asiago, Kathryn Stecco, Salah Hadi, Moetaz Albizem, Holly Tieu, Björn Hock, Craig Fenwick, Kai Lin, Thomas Lengsfeld, Lauren Poffenbarger, David Liu, Didier Trono, Giuseppe Pantaleo, Rajeev Venkayya, Prakash Bhuyan
Publikováno v:
Infectious Diseases and Therapy, Vol 13, Iss 1, Pp 173-187 (2024)
Abstract Introduction COVID-19 remains a significant risk for the immunocompromised given their lower responsiveness to vaccination or infection. Therefore, passive immunity through long-acting monoclonal antibodies (mAbs) offers a needed approach fo
Externí odkaz:
https://doaj.org/article/ae010852240d435b8fc87f0fafd48f33
Autor:
Francisco S. Mesquita, Laurence Abrami, Lucie Bracq, Nattawadee Panyain, Vincent Mercier, Béatrice Kunz, Audrey Chuat, Joana Carlevaro-Fita, Didier Trono, F. Gisou van der Goot
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract SARS-CoV-2 infection requires Spike protein-mediated fusion between the viral and cellular membranes. The fusogenic activity of Spike depends on its post-translational lipid modification by host S-acyltransferases, predominantly ZDHHC20. Pre
Externí odkaz:
https://doaj.org/article/c0981672337f4d919ad77a75de8bbe28
Autor:
Cyril Pulver, Delphine Grun, Julien Duc, Shaoline Sheppard, Evarist Planet, Alexandre Coudray, Raphaël de Fondeville, Julien Pontis, Didier Trono
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-40 (2023)
Abstract Background Transposable elements (TEs) have colonized the genomes of most metazoans, and many TE-embedded sequences function as cis-regulatory elements (CREs) for genes involved in a wide range of biological processes from early embryogenesi
Externí odkaz:
https://doaj.org/article/e4b7bc915ee949289443e890c3baf6b7
Autor:
Julien Pontis, Cyril Pulver, Christopher J. Playfoot, Evarist Planet, Delphine Grun, Sandra Offner, Julien Duc, Andrea Manfrin, Matthias P. Lutolf, Didier Trono
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The human genome harbors more than 4.5 million transposable element (TE)-derived insertions, the result of recurrent waves of invasion and internal propagation. Here they show that TEs belonging to evolutionarily recent subfamilies go on to regulate
Externí odkaz:
https://doaj.org/article/e82e220d3511449c9d94b1deeffca8a6
Autor:
Laia Simó-Riudalbas, Sandra Offner, Evarist Planet, Julien Duc, Laurence Abrami, Sagane Dind, Alexandre Coudray, Mairene Coto-Llerena, Caner Ercan, Salvatore Piscuoglio, Claus Lindbjerg Andersen, Jesper Bertram Bramsen, Didier Trono
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The treatment of colorectal cancer (CRC) is an unmet medical need in absence of early diagnosis. Here, the authors characterise cancer-specific transposable element-driven transpochimeric gene transcripts and highlight the role of POU5F1B in CRC grow
Externí odkaz:
https://doaj.org/article/a38569d1cb844be0bc2d549b4ade75f9
Autor:
Dongchun Ni, Priscilla Turelli, Bertrand Beckert, Sergey Nazarov, Emiko Uchikawa, Alexander Myasnikov, Florence Pojer, Didier Trono, Henning Stahlberg, Kelvin Lau
Publikováno v:
PLoS Pathogens, Vol 19, Iss 4, p e1011206 (2023)
Investigation of potential hosts of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is crucial to understanding future risks of spillover and spillback. SARS-CoV-2 has been reported to be transmitted from humans to various animals af
Externí odkaz:
https://doaj.org/article/28d2bdc862074a1388754a265e04f7d5
Autor:
Alexandra Iouranova, Delphine Grun, Tamara Rossy, Julien Duc, Alexandre Coudray, Michael Imbeault, Jonas de Tribolet-Hardy, Priscilla Turelli, Alexandre Persat, Didier Trono
Publikováno v:
Mobile DNA, Vol 13, Iss 1, Pp 1-17 (2022)
Abstract Background Transposable element-embedded regulatory sequences (TEeRS) and their KRAB-containing zinc finger protein (KZFP) controllers are increasingly recognized as modulators of gene expression. We aim to characterize the contribution of t
Externí odkaz:
https://doaj.org/article/6f57d92deac54daab72efbdeda1cb5df
Autor:
Xinyu Xiang, Yu Tao, Jonathan DiRusso, Fei-Man Hsu, Jinchun Zhang, Ziwei Xue, Julien Pontis, Didier Trono, Wanlu Liu, Amander T. Clark
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The transcription factor network required for primordial germ cell (PGC) specification is known to diverge in mammals. Here the authors show that hominidae-specific transposable element (TE) LTR5Hs becomes transcriptionally active during PGC specific
Externí odkaz:
https://doaj.org/article/355e9c274ddd4b0e8684e5949c16e842
Autor:
Silvia Stringhini, María-Eugenia Zaballa, Nick Pullen, Carlos de Mestral, Javier Perez-Saez, Roxane Dumont, Attilio Picazio, Francesco Pennacchio, Yaron Dibner, Sabine Yerly, Helene Baysson, Nicolas Vuilleumier, Jean-François Balavoine, Delphine Bachmann, Didier Trono, Didier Pittet, François Chappuis, Omar Kherad, Laurent Kaiser, Andrew S. Azman, SEROCoV-WORK + Study Group, Idris Guessous
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
Many job sectors classified as ‘essential’ have continued operating with limited restrictions during the COVID-19 pandemic, potentially placing workers at higher risk of infection. Here, the authors show that seropositivity rates in workers vary
Externí odkaz:
https://doaj.org/article/7e1d9158621d40b6a3b06314fa11152d