Zobrazeno 1 - 10
of 218
pro vyhledávání: '"Didier, Rognan"'
Autor:
Antoine Jouvenel, Adrien Tassou, Maxime Thouaye, Jérôme Ruel, Myriam Antri, Jean-Philippe Leyris, Aurore Giraudin, Sylvie Mallié, Chamroeum Sar, Lucie Diouloufet, Corinne Sonrier, François Daubeuf, Juliette Bertin, Stacy Alves, Stéphanie Ventéo, Nelly Frossard, Patrick Carroll, Ilana Mechaly, Didier Rognan, Pierre Sokoloff, Radhouane Dallel, Patrick Delmas, Jean Valmier, Cyril Rivat
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Navigating the duality of opioids’ potent analgesia and side effects, including tolerance and hyperalgesia, is a significant challenge in chronic pain management, often prompting hazardous dose escalation to maintain analgesic effects. The
Externí odkaz:
https://doaj.org/article/62199c8ab61a47228dbb08f3a3507de8
Publikováno v:
ACS Central Science, Vol 10, Iss 3, Pp 615-627 (2024)
Externí odkaz:
https://doaj.org/article/0acbdf41c0a8410db8769e33bbfe2c99
Autor:
Elena Shanina, Sakonwan Kuhaudomlarp, Eike Siebs, Felix F. Fuchsberger, Maxime Denis, Priscila da Silva Figueiredo Celestino Gomes, Mads H. Clausen, Peter H. Seeberger, Didier Rognan, Alexander Titz, Anne Imberty, Christoph Rademacher
Publikováno v:
Communications Chemistry, Vol 5, Iss 1, Pp 1-11 (2022)
Carbohydrate–protein interactions are key for cell–cell and host–pathogen recognition, but their hydrophilic nature makes the development of drug-like inhibitors a challenge. Here, screening of fragment libraries identifies metal-binding pharma
Externí odkaz:
https://doaj.org/article/4b306191f31141ed861dba296acb045e
Autor:
Merveille Eguida, Didier Rognan
Publikováno v:
Journal of Cheminformatics, Vol 13, Iss 1, Pp 1-13 (2021)
Abstract Rationalizing the identification of hidden similarities across the repertoire of druggable protein cavities remains a major hurdle to a true proteome-wide structure-based discovery of novel drug candidates. We recently described a new comput
Externí odkaz:
https://doaj.org/article/3b6c0f8b42f341fbbf2ac7c15015ffe3
Autor:
Cyril Rivat, Chamroeun Sar, Ilana Mechaly, Jean-Philippe Leyris, Lucie Diouloufet, Corinne Sonrier, Yann Philipson, Olivier Lucas, Sylvie Mallié, Antoine Jouvenel, Adrien Tassou, Henri Haton, Stéphanie Venteo, Jean-Philippe Pin, Eric Trinquet, Fabienne Charrier-Savournin, Alexandre Mezghrani, Willy Joly, Julie Mion, Martine Schmitt, Alexandre Pattyn, Frédéric Marmigère, Pierre Sokoloff, Patrick Carroll, Didier Rognan, Jean Valmier
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Sensitisation of dorsal root ganglia neurons contributes to neuropathic pain. Here the authors demonstrate the cytokine FL contributes to sensitisation of DRGs via its receptor FLT3 expressed on neurons, and identify a novel FLT3 inhibitor that atten
Externí odkaz:
https://doaj.org/article/87fd7efd827f43ad990381c8a9541b42
Autor:
Maud Bollenbach, Simona Nemska, Patrick Wagner, Guillaume Camelin, François Daubeuf, Adeline Obrecht, Pascal Villa, Didier Rognan, Frédéric Bihel, Jean-Jacques Bourguignon, Martine Schmitt, Nelly Frossard
Publikováno v:
Molecules, Vol 26, Iss 2, p 391 (2021)
Mitogen- and Stress-Activated Kinase 1 (MSK1) is a nuclear kinase, taking part in the activation pathway of the pro-inflammatory transcription factor NF-kB and is demonstrating a therapeutic target potential in inflammatory diseases such as asthma, p
Externí odkaz:
https://doaj.org/article/be77ee75372d43f0ba33a96af0aa47d9
Autor:
Romain Hany, Jean-Philippe Leyris, Guillaume Bret, Sylvie Mallié, Chamroeun Sar, Maxime Thouaye, Abdallah Hamze, Olivier Provot, Pierre Sokoloff, Jean Valmier, Pascal Villa, Didier Rognan
Publikováno v:
ACS Chemical Biology
ACS Chemical Biology, 2022, 17 (3), pp.709-722. ⟨10.1021/acschembio.2c00048⟩
ACS Chemical Biology, 2022, 17 (3), pp.709-722. ⟨10.1021/acschembio.2c00048⟩
International audience; nhibiting receptor tyrosine kinases is commonly achieved by two main strategies targeting either the intracellular kinase domain by low molecular weight compounds or the extracellular ligand-binding domain by monoclonal antibo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f41fdf03a3233fc02562674c1e8cbb35
https://doi.org/10.1021/acschembio.2c00048
https://doi.org/10.1021/acschembio.2c00048
Autor:
Antoine Jouvenel, Adrien Tassou, Maxime Thouaye, Jérôme Ruel, Myriam Antri, Jean-Philippe Leyris, Aurore Paquet, Sylvie Mallié, Chamroeum Sar, Lucie Diouloufet, Corinne Sonrier, François Daubeuf, Juliette Bertin, Stacy Alves, Stéphanie Ventéo, Nelly Frossard, Patrick Carroll, Ilana Mechaly, Didier Rognan, Pierre Sokoloff, Radhouane Dallel, Patrick Delmas, Jean Valmier, Cyril Rivat
Opioid analgesia is counteracted on chronic use by tolerance and hyperalgesia inducing dose escalation and life-threatening overdoses. Mu opiate receptors (MOR) expressed in primary sensory neurons were recently found to control tolerance and hyperal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c8034c8ff982ad6b4eac00671207050
https://doi.org/10.1101/2023.03.16.532971
https://doi.org/10.1101/2023.03.16.532971
Target-Focused Library Design by Pocket-Applied Computer Vision and Fragment Deep Generative Linking
Publikováno v:
Journal of medicinal chemistry. 65(20)
We here describe a computational approach (POEM: Pocket Oriented Elaboration of Molecules) to drive the generation of target-focused libraries while taking advantage of all publicly available structural information on protein-ligand complexes. A coll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb05f858bece46aff32cce567a5a1de
https://pubmed.ncbi.nlm.nih.gov/36256484
https://pubmed.ncbi.nlm.nih.gov/36256484
Autor:
Didier ROGNAN, Merveille Eguida
Publikováno v:
International journal of molecular sciences. 23(20)
With the exponential increase in publicly available protein structures, the comparison of protein binding sites naturally emerged as a scientific topic to explain observations or generate hypotheses for ligand design, notably to predict ligand select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::362bbb68f56c2a403adc90818c02bc41
https://pubmed.ncbi.nlm.nih.gov/36293316
https://pubmed.ncbi.nlm.nih.gov/36293316