Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Didier, Cussac"'
Autor:
Teyssier, Lény, Olivier, Lamotte, Estelle, Bonnin, Marie-Jeanne, Crépeau, Didier, Cussac, Sylvain, Jeandroz, David, Wendehenne, Jérôme, Pelloux, Connat, Jean-Louis
Publikováno v:
In Phytomedicine Plus November 2024 4(4)
Autor:
Christian Bailly, Jean-Marc Barret, Nicolas Guilbaud, Charles Dumontet, Didier Cussac, Jean-Philippe Annereau, Jesper Q. Svejstrup, David J. Hobson, Sophie Bréand, Jérome Besse, Laurent Créancier, Luc DeVries, Stéphane Vispé
Supplementary Data from Triptolide is an inhibitor of RNA polymerase I and II–dependent transcription leading predominantly to down-regulation of short-lived mRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9663a2f107aece705dc218648dcf711d
https://doi.org/10.1158/1535-7163.22484879.v1
https://doi.org/10.1158/1535-7163.22484879.v1
Autor:
Christian Bailly, Jean-Marc Barret, Nicolas Guilbaud, Charles Dumontet, Didier Cussac, Jean-Philippe Annereau, Jesper Q. Svejstrup, David J. Hobson, Sophie Bréand, Jérome Besse, Laurent Créancier, Luc DeVries, Stéphane Vispé
Triptolide, a natural product extracted from the Chinese plant Tripterygium wilfordii, possesses antitumor properties. Despite numerous reports showing the proapoptotic capacity and the inhibition of NF-κB–mediated transcription by triptolide, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::228be85587ab7332098bd38bdc32658e
https://doi.org/10.1158/1535-7163.c.6531635
https://doi.org/10.1158/1535-7163.c.6531635
Autor:
Frédérique Lantoine-Adam, Didier Cussac, Eliete Bouskela, Peter Heusler, Isabelle Rauly-Lestienne, Fatima Z. G. A. Cyrino
Publikováno v:
Microvascular Research. 114:1-11
The objectives of this study were to evaluate, in vitro and in vivo, the contribution of muscarinic receptors to the effects of Ruscus extract. Ruscus extract was tested in competition binding experiments at recombinant human muscarinic receptors, he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec433f33d49b7c535d8907391cdd7f4d
https://doi.org/10.1016/j.mvr.2017.05.005
https://doi.org/10.1016/j.mvr.2017.05.005
Publikováno v:
Molecular pharmacology. 96(3)
The dopamine D2 receptor (D2R) mediates ligand-biased signaling with potential therapeutic implications. However, internalization, choice of endocytic routes, and degradation of the D2R in lysosomes may also participate in agonist-directed traffickin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afcfc28d3f4e1848d96312746b6444fb
https://pubmed.ncbi.nlm.nih.gov/31266815
https://pubmed.ncbi.nlm.nih.gov/31266815
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 388:509-516
N-methyl-d-aspartate (NMDA) receptor channels are implicated in a wide range of physiological and pathophysiological processes, and a large number of pharmacological agents have been introduced that target the receptor via diverse mechanisms of actio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e52fbbc1e73e67cd622b49c81a1b48
https://doi.org/10.1007/s00210-015-1085-6
https://doi.org/10.1007/s00210-015-1085-6
Distinctive in vitro signal transduction profile of NLX-112, a potent and efficacious serotonin 5-HT
Autor:
Adrian, Newman-Tancredi, Jean-Claude, Martel, Cristina, Cosi, Peter, Heusler, Fabrice, Lestienne, Mark A, Varney, Didier, Cussac
Publikováno v:
The Journal of pharmacy and pharmacology. 69(9)
NLX-112 (befiradol, F13640) is a selective serotonin 5-HTNLX-112 was tested on G-protein activation, inhibition of adenylyl cyclase, ERK1/2 phosphorylation (pERK) and receptor internalization in recombinant cell lines. NLX-112 was also tested on G-pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3f2649657d3d45a73ad6b03574257bc5
https://pubmed.ncbi.nlm.nih.gov/28612503
https://pubmed.ncbi.nlm.nih.gov/28612503
Autor:
Isabelle Rauly-Lestienne, Didier Cussac, Peter Heusler, Frédéric Finana, Claudie Cathala, Sophie Bernois, Luc De Vries
Publikováno v:
Cellular Signalling. 24:1648-1657
μ-opioid receptors have been shown to form heterodimers with several G protein coupled receptors involved in pain regulation such as α(2A)-adrenergic and neurokinin 1 receptors. Because the 5-HT(1A) receptor is also involved in pain control, we inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5a513be0ee09675930f3fb0004cebdb
https://doi.org/10.1016/j.cellsig.2012.04.010
https://doi.org/10.1016/j.cellsig.2012.04.010
Autor:
Didier Cussac, Elodie Bert, Emilie Lauressergues, Zouher Majd, Bart Staels, Patrick Duriez, Dean W. Hum
Publikováno v:
Neuropharmacology. 62:784-796
Metabolic side effects caused by certain antipsychotic drugs (APDs), in particular clozapine and olanzapine, are now clinically well-documented. However, the potential mechanisms implicated in the metabolic disturbances of these drugs on peripheral t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7726edbd88212ef31dd8601444176a5
https://doi.org/10.1016/j.neuropharm.2011.08.048
https://doi.org/10.1016/j.neuropharm.2011.08.048
Publikováno v:
European Journal of Pharmacology. 669:51-58
N-desmethylclozapine (NDMC or norclozapine) is the major active metabolite of the antipsychotic clozapine in humans. The activity of NDMC differs from clozapine at a number of neurotransmitter receptors, probably influencing the pharmacological effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7390587887ae1e905c24b0d2a063dbdf
https://doi.org/10.1016/j.ejphar.2011.07.031
https://doi.org/10.1016/j.ejphar.2011.07.031