Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Didi Guo"'
Publikováno v:
BMC Pediatrics, Vol 24, Iss 1, Pp 1-5 (2024)
Abstract Germline mutations of NSD1 are associated with Sotos syndrome, characterized by distinctive facial features, overgrowth, and developmental delay. Approximately 3% of individuals with Sotos syndrome develop tumors. In this study, we describe
Externí odkaz:
https://doaj.org/article/c6304de1c8164d6b8aae44c123faacbc
Autor:
Xizan Yue, Bo Liu, Tiantian Han, Ningning Luo, Guanghua Lu, Didi Guo, Fanfeng Bu, Guangyu Wang
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Central nervous system germ cell tumors (CNS GCTs) are a heterogeneous group of primary CNS tumors. GCTs are more common and mostly observed in pediatric and young adult patients. CNS GCTs are divided into germinomas and non-germinomatous germ cell t
Externí odkaz:
https://doaj.org/article/89cc838fbad74b2d904f9e3eea13c7b8
Autor:
Zhiyuan Zhu, Didi Guo, Yiping Li, Hong Fan, Ping Chen, Xiaohui Shen, Zhenghong Yu, Shenling Yu, Qi Qian, Rui Sun
Publikováno v:
Oncology Letters
Di-methylated lysine 9 of histone H3 (H3K9me2), regulated by histone methyltransferases, is involved in the epigenetic regulation of tumor-associated genes. The present study aimed to evaluate whether the H3K9me2 methylation level is associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b85cf65d5b34fcbe42221cdc82fbea8f
https://doi.org/10.3892/ol.2020.11694
https://doi.org/10.3892/ol.2020.11694
Publikováno v:
Journal of Clinical Oncology. 40:e14031-e14031
e14031 Background: KIAA1549-BRAF fusion is the most common genetic event in pilocytic astrocytoma (PA), and leads to activation of the mitogen activated protein kinase (MAPK) signaling pathway. KIAA1549-BRAF fusion has been considered to be a key var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e35bc79e2db949618e41a2aa0c075a72
https://doi.org/10.1200/jco.2022.40.16_suppl.e14031
https://doi.org/10.1200/jco.2022.40.16_suppl.e14031
Publikováno v:
Journal of Clinical Oncology. 40:10578-10578
10578 Background: DICER1 syndrome is a rare genetic condition predisposing to multiple cancer types and causes by germline DICER1 variants. Deleterious mutations identified were mostly located in the RNase III domain. VUSs found in other domains may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5568bde35a241bf7bcc00149d8f833f7
https://doi.org/10.1200/jco.2022.40.16_suppl.10578
https://doi.org/10.1200/jco.2022.40.16_suppl.10578
Autor:
Fan Xu, Qingshan Li, Wenxin LI, Shenglin Zhang, Yaping Zhao, Didi Guo, Zhongyu Lu, Siqi Chen, Guanghua Lu, Fanfeng Bu, Ran Ding, Wanglong Deng
Publikováno v:
Journal of Clinical Oncology. 40:8546-8546
8546 Background: Activating mutations in the ERBB2 gene were shown to play an oncogenic role similar to that of ERBB2 amplification. Thus, ERBB2 mutations have emerged as therapeutic targets in non-small cell lung cancers (NSCLC). However, Activating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e14505a9b599b08d2797f17fa706133c
https://doi.org/10.1200/jco.2022.40.16_suppl.8546
https://doi.org/10.1200/jco.2022.40.16_suppl.8546
Autor:
Xiaobing Wu, Didi Guo, Tiantian Han, Yaping Zhao, Juan Ma, Guanghua Lu, Fanfeng Bu, Siqi Chen, Wanglong Deng, Ran Ding
Publikováno v:
Journal of Clinical Oncology. 40:10585-10585
10585 Background: Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer-related death worldwide with very poor prognosis. Many studies have focused on oncogene characteristics, however, the germline landscape of Chinese HCC patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9db7ce91b933dde6d2e52e36a191b36
https://doi.org/10.1200/jco.2022.40.16_suppl.10585
https://doi.org/10.1200/jco.2022.40.16_suppl.10585
Publikováno v:
Journal of Clinical Oncology. 40:10579-10579
10579 Background: Germline mutations play an important role in cancer risk and susceptibility. With the growing implementation of next generation sequence of multiple gene panel, an increasing number of cases that carry two or more inherited cancer-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50640bd8b6c60fb71f5bd32bcfe8d6e1
https://doi.org/10.1200/jco.2022.40.16_suppl.10579
https://doi.org/10.1200/jco.2022.40.16_suppl.10579
Publikováno v:
Journal of Clinical Oncology. 40:e14012-e14012
e14012 Background: Diffuse midline gliomas (DMGs) with H3 K27 altered are extremely aggressive WHO grade IV tumors, with no significant therapeutic progress made in the past. DMGs with H3 K27 altered have been classified as a rare subtype of glial tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d878d6292c8815585472a3d52d56fa15
https://doi.org/10.1200/jco.2022.40.16_suppl.e14012
https://doi.org/10.1200/jco.2022.40.16_suppl.e14012
Autor:
Pihai Gong, Shaodan Zhang, Ying Hu, Chengcheng Zhao, Yiping Li, Xiaohui Shen, Huazhang Wu, He Cui, Yuejun Gu, Ling Wang, Zhujiang Zhao, Hong Fan, Aifeng Zhang, Didi Guo
Publikováno v:
Oncogene
DNA methyltransferase 3A (DNMT3A) has been recognised as a key element of epigenetic regulation in normal development, and the aberrant regulation of DNMT3A is implicated in multiple types of cancers, especially haematological malignancies. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41d1ea65859eff3350db4ce623b8dcc3
http://europepmc.org/articles/PMC6085280
http://europepmc.org/articles/PMC6085280