Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Dickon M. Humphrey"'
Autor:
Gerald Vinatier, Vincenzo G. Fiore, Edgar Buhl, Danielle C. Diaper, Benjamin L. de Bivort, Chenghao Chen, Raymond J. Dolan, Frank Hirth, Zoe N. Ludlow, Keita Endo, Yoshitsugu Adachi, Sheena Brown, James J L Hodge, Kei Ito, Nicholas J. Strausfeld, Stephan J. Sigrist, Daniel A. Solomon, Jean-René Martin, Alan Stepto, Katherine E. White, Dickon M. Humphrey, Sean M. Buchanan, Richard Faville, Ralf Stanewsky, Benjamin Kottler, Jonah Dearlove
Publikováno v:
BioRxiv
The insect central complex and vertebrate basal ganglia are forebrain centres involved in selection and maintenance of behavioural actions. However, little is known about the formation of the underlying circuits, or how they integrate sensory informa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a2989c701ca55944611538ce5283e21
https://hal.archives-ouvertes.fr/hal-02413547
https://hal.archives-ouvertes.fr/hal-02413547
Publikováno v:
Frontiers in Neuroscience, Vol 4 (2010)
Drosophila models of Parkinson’s disease are characterised by two principal phenotypes: the specific loss of dopaminergic neurons in the aging brain and defects in motor behavior. However, an age-related analysis of these baseline parameters in wil
Externí odkaz:
https://doaj.org/article/6622a82ebfb44b8a8346c545024e5ff0
Autor:
Frank Hirth, Rawan Alsubaie, Dickon M. Humphrey, Simon Lowe, Luke Lazarou, Stephen Buckley, Angelique di Domenico, Daniel A. Solomon, Fabio Andre Amaral Lopes Simoes, Yoshitsugu Adachi, Max Greenstein, Christopher Shaw, Daryl Cheng, Danielle Diaper
Publikováno v:
Human Molecular Genetics
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are neurodegenerative disorders that are characterized by cytoplasmic aggregates and nuclear clearance of TAR DNA-binding protein 43 (TDP-43). Studies in Drosophila, zeb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49c8b8a56ee7d7f23875a42e8a04f106
http://europepmc.org/articles/PMC3766182
http://europepmc.org/articles/PMC3766182
Autor:
Iain M. Robinson, Alan Stepto, Lies Vanden Broeck, Patrick Callaerts, Ben Sutcliffe, Zoe N. Ludlow, Christopher Shaw, Dickon M. Humphrey, Frank Hirth, Christopher J. H. Elliott, Bart Dermaut, Ammar Al-Chalabi, Danielle Diaper, Yoshitsugu Adachi
Publikováno v:
Human Molecular Genetics
HUMAN MOLECULAR GENETICS
HUMAN MOLECULAR GENETICS
Cytoplasmic accumulation and nuclear clearance of TDP-43 characterize familial and sporadic forms of amyotrophic lateral sclerosis and frontotemporal lobar degeneration, suggesting that either loss or gain of TDP-43 function, or both, cause disease f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a521c24483fbae20c0bf328df16400
https://doi.org/10.1093/hmg/ddt005
https://doi.org/10.1093/hmg/ddt005
Publikováno v:
Journal of Biological Chemistry. 287:36845-36853
UCP1 catalyzes proton leak across the mitochondrial inner membrane to disengage substrate oxidation from ATP production. It is well established that UCP1 is activated by fatty acids and inhibited by purine nucleotides, but precisely how this regulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bf53a1e5bc82a1cc13d82a7bcecb5e6
https://doi.org/10.1074/jbc.m112.381780
https://doi.org/10.1074/jbc.m112.381780
Autor:
Serge Birman, Thomas Riemensperger, Giovanni Esposito, Frank Hirth, Zoe N. Ludlow, Howard T. Jacobs, Richard B. Parsons, Patrik Verstreken, Dickon M. Humphrey
Publikováno v:
Human Molecular Genetics. 21:2698-2712
Mitochondrial dysfunction is commonly observed in degenerative disorders, including Alzheimer's and Parkinson's disease that are characterized by the progressive and selective loss of neuronal subpopulations. It is currently unclear, however, whether
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226a3ad6e70c4fc0dea58614acaeeafe
https://doi.org/10.1093/hmg/dds096
https://doi.org/10.1093/hmg/dds096
Publikováno v:
Experimental Gerontology
Uncoupling proteins (UCPs) can dissipate mitochondrial protonmotive force by increasing the proton conductance of the inner membrane and through this effect could decrease ROS production, ameliorate oxidative stress and extend lifespan. We investigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e45d0c104010bb0f1ec321c27cd8968