Výsledky vyhledávání - "Dickey Chad A"

Akademický článek

Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden

Autor: Abisambra Jose F, Peters Melinda, Kraft Clara, Jones Jeffrey R, Koren John, Jinwal Umesh K, Johnson Amelia G, Congdon Erin E, Blair Laura J, Marinec Paul, Li Qingyou, O'Leary John C, Duff Karen E, Weeber Edwin J, Gestwicki Jason E, Dickey Chad A

Publikováno v: Molecular Neurodegeneration, Vol 5, Iss 1, p 45 (2010)

Abstract Background It has traditionally been thought that the pathological accumulation of tau in Alzheimer's disease and other tauopathies facilitates neurodegeneration, which in turn leads to cognitive impairment. However, recent evidence suggests

Externí odkaz: https://doaj.org/article/a278319ae4704e5a8526dd27afba4ede

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Akademický článek

LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice

Autor: Gordon Marcia N, Blair Laura, Johnson Amelia, Kraft Clara, Reid Patrick, Selenica Maj-Linda B, Rizer Justin, Lee Daniel C, Dickey Chad A, Morgan Dave

Publikováno v: Journal of Neuroinflammation, Vol 7, Iss 1, p 56 (2010)

Abstract Inflammation and microglial activation are associated with Alzheimer's disease (AD) pathology. Somewhat surprisingly, injection of a prototypical inflammatory agent, lipopolysaccharide (LPS) into brains of amyloid precursor protein (APP) tra

Externí odkaz: https://doaj.org/article/bf135ff08d18407bb0f5de1a2b62cce6

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Akademický článek

Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression

Autor: Dickey Chad A, Ash Peter, Klosak Natalia, Lee Wing C, Petrucelli Leonard, Hutton Michael, Eckman Christopher B

Publikováno v: Molecular Neurodegeneration, Vol 1, Iss 1, p 6 (2006)

Abstract The microtubule-associated protein tau (MAPT) is a pathological component of several neurodegenerative diseases and clinical dementias. Here, we have investigated the effects of a series of commercially available FDA-approved compounds and n

Externí odkaz: https://doaj.org/article/c960094c5285458bad987d73315ad918

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Akademický článek

Dysregulation of Na+/K+ ATPase by amyloid in APP+PS1 transgenic mice

Autor: Freeman Melissa J, Herber Donna L, Wilcock Donna M, Gordon Marcia N, Dickey Chad A, Morgan Dave

Publikováno v: BMC Neuroscience, Vol 6, Iss 1, p 7 (2005)

Abstract Background The pathology of Alzheimer's disease (AD) is comprised of extracellular amyloid plaques, intracellular tau tangles, dystrophic neurites and neurodegeneration. The mechanisms by which these various pathological features arise are u

Externí odkaz: https://doaj.org/article/f970a16ada5144ed98158cdd459bdd8f

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