Výsledky vyhledávání - "Dickenson Anthony H"

Akademický článek

Specific involvement of atypical PKCζ/PKMζ in spinal persistent nociceptive processing following peripheral inflammation in rat

Autor: Marchand Fabien, D'Mello Richard, Yip Ping K, Calvo Margarita, Muller Emilie, Pezet Sophie, Dickenson Anthony H, McMahon Stephen B

Publikováno v: Molecular Pain, Vol 7, Iss 1, p 86 (2011)

Abstract Background Central sensitization requires the activation of various intracellular signalling pathways within spinal dorsal horn neurons, leading to a lowering of activation threshold and enhanced responsiveness of these cells. Such plasticit

Externí odkaz: https://doaj.org/article/51fc79479cd54641bc8785c3385896f7

Zobrazit plný text záznamu

Akademický článek

Descending serotonergic facilitation and the antinociceptive effects of pregabalin in a rat model of osteoarthritic pain

Autor: Dolphin Annette C, Vonsy Jean-Laurent, Bannister Kirsty, Bauer Claudia S, Rahman Wahida, Dickenson Anthony H

Publikováno v: Molecular Pain, Vol 5, Iss 1, p 45 (2009)

Abstract Background Descending facilitation, from the brainstem, promotes spinal neuronal hyperexcitability and behavioural hypersensitivity in many chronic pain states. We have previously demonstrated enhanced descending facilitation onto dorsal hor

Externí odkaz: https://doaj.org/article/0bc99de1e3304cb2a39f618023f6e409

Zobrazit plný text záznamu

Akademický článek

Formalin-induced behavioural hypersensitivity and neuronal hyperexcitability are mediated by rapid protein synthesis at the spinal level

Autor: Wallace Victoria C, Asante Curtis O, Dickenson Anthony H

Publikováno v: Molecular Pain, Vol 5, Iss 1, p 27 (2009)

Abstract Background The mammalian target of rapamycin (mTOR) is a key regulator of mRNA translation whose action can be inhibited by the drug rapamycin. Forms of long-term plasticity require protein synthesis and evidence indicates that mRNA in dendr

Externí odkaz: https://doaj.org/article/35bfaa18432b48fa92609787b40f9b95

Zobrazit plný text záznamu

Akademický článek

Behavioural and electrophysiological characterisation of experimentally induced osteoarthritis and neuropathy in C57Bl/6 mice

Autor: Dickenson Anthony H, Harvey Victoria L

Publikováno v: Molecular Pain, Vol 5, Iss 1, p 18 (2009)

Abstract Background Osteoarthritis is a widespread condition affecting the elderly where ~70–90% of over 75 year olds are affected, representing one of the largest cost burdens to healthcare in the western world. The monosodium iodoacetate (MIA) os

Externí odkaz: https://doaj.org/article/5c36d907d4d64e9d8b77d5422bcc4c2b

Zobrazit plný text záznamu

Akademický článek

Enhanced pre-synaptic glutamate release in deep-dorsal horn contributes to calcium channel alpha-2-delta-1 protein-mediated spinal sensitization and behavioral hypersensitivity

Autor: Dickenson Anthony H, Feng Guoping, Kim Doo-Sik, Matthews Elizabeth A, Deng Ping, Nguyen David, Xu Zao C, Luo Z David

Publikováno v: Molecular Pain, Vol 5, Iss 1, p 6 (2009)

Abstract Nerve injury-induced expression of the spinal calcium channel alpha-2-delta-1 subunit (Cavα2δ1) has been shown to mediate behavioral hypersensitivity through a yet identified mechanism. We examined if this neuroplasticity modulates behavio

Externí odkaz: https://doaj.org/article/4a52509d171f47859c03370da4679243

Zobrazit plný text záznamu

Akademický článek

Nav 1.8-null mice show stimulus-dependent deficits in spinal neuronal activity

Autor: Wood John N, Matthews Elizabeth A, Dickenson Anthony H

Publikováno v: Molecular Pain, Vol 2, Iss 1, p 5 (2006)

Abstract Background The voltage gated sodium channel Nav 1.8 has a highly restricted expression pattern to predominantly nociceptive peripheral sensory neurones. Behaviourally Nav 1.8-null mice show an increased acute pain threshold to noxious mechan

Externí odkaz: https://doaj.org/article/16d4f139415d43ee87ef27f694dc04fd

Zobrazit plný text záznamu