Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Dick de Wildt"'
Respiratory Arrest as Main Determinant of Toxicity due to Overdose with Different β-Blockers in Rats
Publikováno v:
Acta Pharmacologica et Toxicologica. 57:352-356
Propranolol, timolol and sotalol were compared regarding their toxicological effects on the cardiovascular and respiratory system. Each drug was administered intravenously to anaesthetized spontaneously breathing and artificially ventilated rats. Aft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9704d812e583bca5044916f141b71d59
https://doi.org/10.1111/j.1600-0773.1985.tb00057.x
https://doi.org/10.1111/j.1600-0773.1985.tb00057.x
Autor:
B. Sangster, Dick de Wildt
Publikováno v:
Journal of Pharmacological Methods. 10:55-64
Potential indices of myocardial contractility derived from aortic blood flow, measured by means of electromagnetic flowmetry, were evaluated in rats under different ventricular loading conditions and were compared with the familiar contractility inde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5925423c5c924bbb70e87e15b599ed32
https://doi.org/10.1016/0160-5402(83)90014-1
https://doi.org/10.1016/0160-5402(83)90014-1
Calcium Interferes with the Cardiodepressive Effects of Beta-Blocker Overdose in Isolated Rat Hearts
Publikováno v:
Journal of Toxicology: Clinical Toxicology. 24:111-133
Propranolol, timolol and sotalol were compared with respect to their cardiotoxic properties in isolated, spontaneously beating rat hearts. Propranolol and timolol induced a dose-dependent decrease in myocardial contractility. A high dose of sotalol h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89b1f096ae7fef026e9a89cd6c35088f
https://doi.org/10.3109/15563658608990451
https://doi.org/10.3109/15563658608990451
Publikováno v:
Journal of toxicology. Clinical toxicology. 22(2)
Propranolol, timolol and sotalol were compared regarding their cardiotoxic properties in isolated, perfused and catecholamine depleted rat hearts. Catecholamine depletion was performed in order to exclude interference of the drugs with beta-adrenergi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78fdf517ed565477d5d29b1fd6677baf
https://pubmed.ncbi.nlm.nih.gov/6502785
https://pubmed.ncbi.nlm.nih.gov/6502785
Publikováno v:
Nephron. 50(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d515c51bf78862ee5375470f2d961581
https://pubmed.ncbi.nlm.nih.gov/2971888
https://pubmed.ncbi.nlm.nih.gov/2971888
Publikováno v:
Journal of toxicology. Clinical toxicology. 23(4-6)
Artificially ventilated anesthetized dogs were given imipramine 7.5 mg/kg/hr i.v. In the first group (n = 6) mechanical cardiac activity was no longer detectable after a cumulative dose of 20.0 +/- 6.6 mg/kg (mean +/- sd). When aortic flow had decrea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7126bea41822cf53a9820ce1ebd2da2
https://pubmed.ncbi.nlm.nih.gov/4057329
https://pubmed.ncbi.nlm.nih.gov/4057329