Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Dick Wu"'
Publikováno v:
PLoS Biology, Vol 13, Iss 10, p e1002267 (2015)
In forebrain neurons, Ca(2+) triggers exocytosis of readily releasable vesicles by binding to synaptotagmin-1 and -7, thereby inducing fast and slow vesicle exocytosis, respectively. Loss-of-function of synaptotagmin-1 or -7 selectively impairs the f
Externí odkaz:
https://doaj.org/article/164b3e3dfbf444d88099605b9b6e41a9
Publikováno v:
Proceedings of the National Academy of Sciences. 116:7113-7122
Homeostatic synaptic plasticity is a stabilizing mechanism engaged by neural circuits in response to prolonged perturbation of network activity. The non-Hebbian nature of homeostatic synaptic plasticity is thought to contribute to network stability b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c2c4dfa34b5c402bdbf3e0a6580b921
https://doi.org/10.1073/pnas.1820690116
https://doi.org/10.1073/pnas.1820690116
Autor:
Taulant Bacaj, Dick Wu, Wei Xu, Robert C. Malenka, Lu Chen, Thomas C. Südhof, Debanjan Goswami, Kristin L. Arendt, Wade Morishita
Publikováno v:
Nature
Strengthening of synaptic connections by NMDA (N-methyl-d-aspartate) receptor-dependent long-term potentiation (LTP) shapes neural circuits and mediates learning and memory. During the induction of NMDA-receptor-dependent LTP, Ca2+ influx stimulates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8fefee2205b2187a6821e6e8a024d65
http://europepmc.org/articles/PMC5734942
http://europepmc.org/articles/PMC5734942
Autor:
Thomas C. Südhof, Peng Zhou, Dick Wu, Taulant Bacaj, Xiaofei Yang, Robert C. Malenka, Wei Xu, Wade Morishita
Publikováno v:
Neuron. 80(4):947-959
In forebrain neurons, knockout of synaptotagmin-1 blocks fast Ca(2+)-triggered synchronous neurotransmitter release but enables manifestation of slow Ca(2+)-triggered asynchronous release. Here, we show using single-cell PCR that individual hippocamp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30f1bb8475fe45b3c76978945e49cdc0
Publikováno v:
Biophysical Journal. 99(11):3599-3608
The KCNE1 auxiliary subunit coassembles with the Kv7.1 channel and modulates its properties to generate the cardiac IKs current. Recent biophysical evidence suggests that KCNE1 interacts with the voltage-sensing domain (VSD) of Kv7.1. To investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8d6823647dd26e71d1e40849191e1bd
Publikováno v:
The Journal of General Physiology
The voltage-sensing domain of voltage-gated channels is comprised of four transmembrane helices (S1–S4), with conserved positively charged residues in S4 moving across the membrane in response to changes in transmembrane voltage. Although it has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa20356129e914409721dc002a304032
https://doi.org/10.1085/jgp.201010408
https://doi.org/10.1085/jgp.201010408
Publikováno v:
PLoS Biology, Vol 13, Iss 10, p e1002267 (2015)
PLoS Biology
PLoS Biology
In forebrain neurons, Ca2+ triggers exocytosis of readily releasable vesicles by binding to synaptotagmin-1 and -7, thereby inducing fast and slow vesicle exocytosis, respectively. Loss-of-function of synaptotagmin-1 or -7 selectively impairs the fas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b245a02cf6cb79dec287507adf64da1e
http://europepmc.org/articles/PMC4593569?pdf=render
http://europepmc.org/articles/PMC4593569?pdf=render
Autor:
Ada Xin Yee, Lu Chen, Jason Aoto, Jason P. Covy, Robert C. Malenka, Csaba Földy, Sung-Jin Lee, Dick Wu, Garret R. Anderson, Katsuhiko Tabuchi, Thomas C. Südhof
Publikováno v:
Cell, vol 162, iss 3
Summaryα- and β-neurexins are presynaptic cell-adhesion molecules implicated in autism and schizophrenia. We find that, although β-neurexins are expressed at much lower levels than α-neurexins, conditional knockout of β-neurexins with continued
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3e07ed23c8a6d8b67173d6526db8ab6
https://escholarship.org/uc/item/2rr706gf
https://escholarship.org/uc/item/2rr706gf
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 4/2/2019, Vol. 116 Issue 14, p7113-7122, 10p
Autor:
Thomas J. Younts, Yea Jin Kaeser-Woo, Thomas C. Südhof, Peng Zhou, Xiaofei Yang, Pablo E. Castillo, Dick Wu
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(23)
Synaptotagmin-12 (Syt12) is an abundant synaptic vesicle protein that--different from other synaptic vesicle-associated synaptotagmins--does not bind Ca(2+). Syt12 is phosphorylated by cAMP-dependent protein kinase-A at serine-97 in an activity-depen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0531c583218816a412dce666b47ed62a
https://pubmed.ncbi.nlm.nih.gov/23739973
https://pubmed.ncbi.nlm.nih.gov/23739973