Zobrazeno 1 - 10
of 285
pro vyhledávání: '"Dick Hoekstra"'
Publikováno v:
Pharmaceutics, Vol 6, Iss 4, Pp 557-583 (2014)
The blood–brain barrier acts as a physical barrier that prevents free entry of blood-derived substances, including those intended for therapeutic applications. The development of molecular Trojan horses is a promising drug targeting technology that
Externí odkaz:
https://doaj.org/article/579c748e1d424aa99b8095a133a63ff4
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155317 (2016)
In oligodendrocytes (OLGs), an indirect, transcytotic pathway is mediating transport of de novo synthesized PLP, a major myelin specific protein, from the apical-like plasma membrane to the specialized basolateral-like myelin membrane to prevent its
Externí odkaz:
https://doaj.org/article/7f9c2327eceb4555bdb2c6e85ef24608
Autor:
Dick Hoekstra, Olaf Maier, Johanna M. van der Wouden, Tounsia Aït Slimane, Sven C.D. van IJzendoorn
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 5, Pp 869-877 (2003)
In recent years, glycosphingolipids (GSLs) have attracted widespread attention due to the appreciation that this class of lipids has a major impact on biological life. Inhibition of the synthesis of glucosylceramide, which serves as a precursor for t
Externí odkaz:
https://doaj.org/article/808ddcc40923454bb7395ee4cf5e199a
Publikováno v:
Journal of the Serbian Chemical Society, Vol 68, Iss 1, Pp 25-33 (2003)
Under hypoglycemic conditions, concomitant hyperinsulinism causes an apparent modification of hemoglobin (Hb) which is manifested by its aggregation (Niketi} et al., Clin. Chim. Acta 197 (1991) 47). In the present work the causes and mechanisms under
Externí odkaz:
https://doaj.org/article/58d5b40c1c784fb4b27550270448d6f8
Autor:
Hande Ozgen, Waldemar Schrimpf, Jelle Hendrix, Jenny C de Jonge, Don C Lamb, Dick Hoekstra, Nicoletta Kahya, Wia Baron
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101834 (2014)
In the central nervous system, lipid-protein interactions are pivotal for myelin maintenance, as these interactions regulate protein transport to the myelin membrane as well as the molecular organization within the sheath. To improve our understandin
Externí odkaz:
https://doaj.org/article/e2c75094ac42425fac3a89fed2eef6ab
Autor:
Katica Stojanov, Erik F.J. de Vries, Dick Hoekstra, Aren van Waarde, Rudi A.J.O. Dierckx, Inge S. Zuhorn
Publikováno v:
Molecular Imaging, Vol 11 (2012)
The introduction of neural stem cells into the brain has promising therapeutic potential for the treatment of neurodegenerative diseases. To monitor the cellular replacement therapy, that is, to determine stem cell migration, survival, and differenti
Externí odkaz:
https://doaj.org/article/a11b677c5dff4752ab19095441aeb110
Autor:
Kati Juuti-Uusitalo, Leon J Klunder, Klaas A Sjollema, Katarina Mackovicova, Ryuichi Ohgaki, Dick Hoekstra, Jan Dekker, Sven C D van Ijzendoorn
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e22967 (2011)
BackgroundThe cytokines TNF (TNFSF2) and IFNγ are important mediators of inflammatory bowel diseases and contribute to enhanced intestinal epithelial permeability by stimulating apoptosis and/or disrupting tight junctions. Apoptosis and tight juncti
Externí odkaz:
https://doaj.org/article/f0fff36a3114460bae10423387651c0b
Autor:
Peng Wang, Sandra Amor, Wia Baron, Jenny C. de Jonge, Chao Zhao, Dick Hoekstra, Muhammad Nazmuddin, Rianne P. Gorter
Publikováno v:
Wang, P, Gorter, R P, de Jonge, J C, Nazmuddin, M, Zhao, C, Amor, S, Hoekstra, D & Baron, W 2018, ' MMP7 cleaves remyelination-impairing fibronectin aggregates and its expression is reduced in chronic multiple sclerosis lesions ', GLIA, vol. 66, no. 8, pp. 1625-1643 . https://doi.org/10.1002/glia.23328
GLIA, 66(8), 1625-1643. John Wiley and Sons Inc.
Glia, 66(8), 1625-1643. Wiley
Glia
GLIA, 66(8), 1625-1643. John Wiley and Sons Inc.
Glia, 66(8), 1625-1643. Wiley
Glia
Upon demyelination, transient expression of fibronectin precedes successful remyelination. However, in chronic demyelination observed in multiple sclerosis (MS), aggregates of fibronectin persist and contribute to remyelination failure. Accordingly,
Autor:
Dick Hoekstra
Publikováno v:
Membrane Fusion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fb7ada2bfd7f9f8ddafcfd5fc13bd51
https://doi.org/10.1201/9780367811525-14
https://doi.org/10.1201/9780367811525-14
Autor:
Dick Hoekstra, Jan Willem Kok, Vera J. M. Nies, Jenny C. de Jonge, Johan W. Jonker, Arend H. Sikkema, Jing Qin, Kristine van der Bij, Wia Baron, Karin Klappe
Publikováno v:
The Journal of Neuroscience, 37(41), 9925-9938. Oxford University Press
Remyelination failure by oligodendrocytes contributes to the functional impairment that characterizes the demyelinating disease multiple sclerosis (MS). Since incomplete remyelination will irreversibly damage axonal connections, treatments effectivel