Zobrazeno 1 - 10
of 3 584
pro vyhledávání: '"Dick F."'
Autor:
Luuk E. de Vries, Aldo Jongejan, Jennifer Monteiro Fortes, Rawien Balesar, Annemieke J. M. Rozemuller, Perry D. Moerland, Inge Huitinga, Dick F. Swaab, Joost Verhaagen
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-24 (2024)
Abstract Some individuals show a discrepancy between cognition and the amount of neuropathological changes characteristic for Alzheimer’s disease (AD). This phenomenon has been referred to as ‘resilience’. The molecular and cellular underpinnin
Externí odkaz:
https://doaj.org/article/e03528769b2a4a3cb0f3eb56cfdfb93b
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-33 (2024)
Abstract Some individuals are able to maintain their cognitive abilities despite the presence of significant Alzheimer’s Disease (AD) neuropathological changes. This discrepancy between cognition and pathology has been labeled as resilience and has
Externí odkaz:
https://doaj.org/article/366a52247abc420094a7a727d47c1fd6
Autor:
Lin Zhang, Ronald W.H. Verwer, Joop van Heerikhuize, Paul J. Lucassen, Peter W. Nathanielsz, Elly M. Hol, Eleonora Aronica, Waljit S. Dhillo, Gerben Meynen, Dick F. Swaab
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-14 (2024)
Abstract The human hypothalamus modulates mental health by balancing interactions between hormonal fluctuations and stress responses. Stress-induced progesterone release activates progesterone receptors (PR) in the human brain and triggers alteration
Externí odkaz:
https://doaj.org/article/f3ec194bdc2c4ca6b6f0a9737f68b276
Autor:
Felipe Correa-da-Silva, Martin J. Kalsbeek, Femke S. Gadella, Jorn Oppersma, Wei Jiang, Samantha E. C. Wolff, Nikita L. Korpel, Dick F. Swaab, Eric Fliers, Andries Kalsbeek, Chun-Xia Yi
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-13 (2023)
Abstract Evidence from animal experiments has shown that the hypothalamic paraventricular nucleus (PVN) plays a key role in regulating body weight and blood glucose levels. However, it is unclear whether neuron populations in the human PVN are involv
Externí odkaz:
https://doaj.org/article/6857b8695bea4e418b99582681d471fb
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
IntroductionPituitary adenylate cyclase-activating peptide (PACAP) is a stress-related neuropeptide that is produced in several brain areas. It acts by 3 receptors: PACAP type-1 (PAC1), vasoactive intestinal peptide (VIP) -1 and -2 (VPAC1 and 2). Dat
Externí odkaz:
https://doaj.org/article/9c34d1a72e7d46b79d881e6c9ec9bf06
Autor:
Zala Slabe, Gwyneth A. Pechler, Joop van Heerikhuize, Benjamin A. Samuels, Marko Živin, Maja Zorović, Dick F. Swaab
Publikováno v:
Neurobiology of Disease, Vol 183, Iss , Pp 106191- (2023)
The mood disorders major depressive disorder (MDD) and bipolar disorder (BD) are highly prevalent worldwide. Women are more vulnerable to these psychopathologies than men. The bed nucleus of the stria terminalis (BNST), the amygdala, and the hypothal
Externí odkaz:
https://doaj.org/article/2db9af37b7a34da7b8e991dcbf584276
Autor:
Sabina Luchetti, Philippe Liere, Antoine Pianos, Ronald W.H. Verwer, Arja Sluiter, Inge Huitinga, Michael Schumacher, Dick F. Swaab, Matthew R.J. Mason
Publikováno v:
Neurobiology of Disease, Vol 183, Iss , Pp 106169- (2023)
Neuroactive steroids are known neuroprotective agents and neurotransmitter regulators. We previously found that expression of the enzymes synthesizing 5α-dihydroprogesterone (5α-DHP), allopregnanolone (ALLO), and dehydroepiandrosterone sulfate (DHE
Externí odkaz:
https://doaj.org/article/98b77096537a4453ac25d7b3fb869775
Autor:
Lei Guo, Yang-Jian Qi, Hong Tan, Dan Dai, Rawien Balesar, Arja Sluiter, Joop van Heerikhuize, Shao-Hua Hu, Dick F. Swaab, Ai-Min Bao
Publikováno v:
EBioMedicine, Vol 84, Iss , Pp 104266- (2022)
Summary: Background: Oxytocin (OXT) and corticotropin-releasing hormone (CRH) are both produced in hypothalamic paraventricular nucleus (PVN). Central CRH may cause depression-like symptoms, while peripheral higher OXT plasma levels were proposed to
Externí odkaz:
https://doaj.org/article/9ad715b556a8455c8182c0721a5b7df8
Autor:
Li Cheng, Cenglin Xu, Lu Wang, Dadao An, Lei Jiang, Yanrong Zheng, Yixin Xu, Yi Wang, Yujing Wang, Kuo Zhang, Xiaodong Wang, Xiangnan Zhang, Aimin Bao, Yudong Zhou, Jingyu Yang, Shumin Duan, Dick F. Swaab, Weiwei Hu, Zhong Chen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Social impairment and anhedonia are common negative symptoms in patients with schizophrenia. Here, the authors show that the histamine H1 receptor in cholinergic neurons in the basal forebrain has a critical role in sensorimotor gating, social behavi
Externí odkaz:
https://doaj.org/article/a784f8fd02d24f0898a211da04d363c4
Neurofibrillary Pathology in the Infundibular Nucleus in Relation to Age and Abnormal Hormone Levels
Autor:
Andon Hestiantoro, Dick F. Swaab
Publikováno v:
Indonesian Journal of Obstetrics and Gynecology, Pp 196-207 (2019)
Abstract Objective: to determine whether the decline of testosterone during ageing would make this nucleus more vulnerable for NF changes (i.e. hyperphosphorylated-tau) in men, or that the decline of estrogens in the postmenopausal period would pr
Externí odkaz:
https://doaj.org/article/d65540eb5c32495c8fc4b92d5329be82