Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Dick D. Mosser"'
Autor:
Tammy Ryan, Vladimir V. Bamm, Morgan G. Stykel, Carla L. Coackley, Kayla M. Humphries, Rhiannon Jamieson-Williams, Rajesh Ambasudhan, Dick D. Mosser, Stuart A. Lipton, George Harauz, Scott D. Ryan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Cardiolipin is a phospholipid component of the inner mitochondrial membrane. Here the authors demonstrate that cardiolipin interacts with mutant α-synuclein, and that impaired cardiolipin function can lead to spread of α-synuclein between neurons.
Externí odkaz:
https://doaj.org/article/0839cad1dc084b31b2fb1c7ae7cd4162
Publikováno v:
The Scientific World Journal, Vol 1, Pp 36-36 (2001)
Externí odkaz:
https://doaj.org/article/f6a8b1a76d3d453c859b880a7a87bbcc
Publikováno v:
Cell Stress Chaperones
Cells respond to stress through adaptive mechanisms that limit cellular damage and prevent cell death. MicroRNAs act as regulators of stress responses and stress can impact the functioning of miRNA biogenesis pathways. We were interested in the effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cccfcf98530aff1771c30826f7322b71
https://europepmc.org/articles/PMC8821752/
https://europepmc.org/articles/PMC8821752/
Publikováno v:
DNA Repair. 88:102805
This study was initiated to examine the effects of caffeine on the DNA damage response (DDR) and homologous recombination (HR) in mammalian cells. A 5 mM caffeine treatment caused the cell cycle to stall at G2/M and cells eventually underwent apoptos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d078b03489d149eda20324120e4fc1
https://doi.org/10.1016/j.dnarep.2020.102805
https://doi.org/10.1016/j.dnarep.2020.102805
Autor:
Scott D. Ryan, Rhiannon Jamieson-Williams, Dick D. Mosser, Tammy Ryan, Vladimir V. Bamm, Morgan G. Stykel, Stuart A. Lipton, Carla Coackley, Kayla M. Humphries, George Harauz, Rajesh Ambasudhan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature Communications
Nature Communications
Neuronal loss in Parkinson’s disease (PD) is associated with aberrant mitochondrial function and impaired proteostasis. Identifying the mechanisms that link these pathologies is critical to furthering our understanding of PD pathogenesis. Using hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60ed36415227191aabbef0a9e75da80a
https://doi.org/10.1038/s41467-018-03241-9
https://doi.org/10.1038/s41467-018-03241-9
Publikováno v:
Journal of Biological Chemistry. 290:11443-11454
Hyperthermia is a proteotoxic stress that is lethal when exposure is extreme but also cytoprotective in that sublethal exposure leads to the synthesis of heat shock proteins, including HSP70, which are able to inhibit stress-induced apoptosis. CDK5 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5b56da47b279fc881d0ce2df8e76960
https://doi.org/10.1074/jbc.m114.625988
https://doi.org/10.1074/jbc.m114.625988
Autor:
Leanne M. Delaney, Jodi Morrison, Dick D. Mosser, Nelson Ho, Brenda L. Coomber, Nathan Farias
Publikováno v:
Apoptosis. 20:63-74
Dichloroacetate (DCA) is a metabolic reprogramming agent that reverses the Warburg effect, causing cancer cells to couple glycolysis to oxidative phosphorylation. This has been shown to induce apoptosis and reduce the growth of various types of cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7363c540a3be883c797328568cca44f4
https://doi.org/10.1007/s10495-014-1046-4
https://doi.org/10.1007/s10495-014-1046-4
Publikováno v:
IUBMB Life. 66:327-338
Thermotolerance, the acquired resistance of cells to stress, is a well-established phenomenon. Studies of the key mediators of this response, the heat shock proteins (HSPs), have led to the discovery of the important roles played by these proteins in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48013fb19b2d727f770827252600ac4b
https://doi.org/10.1002/iub.1274
https://doi.org/10.1002/iub.1274
This study was initiated to examine the effects of caffeine on the DNA damage response (DDR) and homologous recombination (HR). An initial 2 h exposure to 5 mM caffeine slowed a fraction of the cells in G1, but thereafter, continued caffeine exposure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bb697be0fe337fbcdf6c6cc4bd8d9b6
Publikováno v:
Journal of Cell Science. 124:2367-2374
Hyperthermia adversely affects cell structure and function, but also induces adaptive responses that allow cells to tolerate these stressful conditions. For example, heat-induced expression of the molecular chaperone protein HSP70 can prevent stress-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1326be8e3506bf158d0262136c7c3af2
https://doi.org/10.1242/jcs.081745
https://doi.org/10.1242/jcs.081745