Zobrazeno 1 - 10
of 2 586
pro vyhledávání: '"Dick B"'
Autor:
Nikolas Capra, Chloé Lelièvre, Océane Touré, Aurélie Fossey-Jouenne, Carine Vergne-Vaxelaire, Dick B. Janssen, Andy-Mark W. H. Thunnissen, Anne Zaparucha
Publikováno v:
Frontiers in Catalysis, Vol 4 (2024)
The CoA ligase from Metallosphaera sedula (MsACL) can be used for the chemoenzymatic synthesis of amides from carboxylic acids. In this CoA-independent conversion, the enzyme catalyzes the adenylation of a carboxylic acid with the help of ATP, follow
Externí odkaz:
https://doaj.org/article/e79be1107d974a38a3146cf5d3218eee
Publikováno v:
One Health, Vol 15, Iss , Pp 100419- (2022)
In recent years it has become evident that a healthy intestinal microbiome is beneficial for the overall health of an individual. A healthy microbiome is diverse, increasing stability and resilience and strengthening the immune system. In addition, h
Externí odkaz:
https://doaj.org/article/5717f92238ff40d5872826cb2de63471
Publikováno v:
Frontiers in Catalysis, Vol 2 (2022)
Protein engineering is a powerful and widely applied tool for tailoring enzyme properties to meet application-specific requirements. An attractive group of biocatalysts are PLP-dependent amine transaminases which are capable of converting prochiral k
Externí odkaz:
https://doaj.org/article/39999081950b43df80b7f653713a0e58
Autor:
Ana Toplak, Eduardo F. Teixeira de Oliveira, Marcel Schmidt, Henriëtte J. Rozeboom, Hein J. Wijma, Linda K.M. Meekels, Rowin de Visser, Dick B. Janssen, Timo Nuijens
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 1277-1287 (2021)
Omniligase-1 is a broadly applicable enzyme for peptide bond formation between an activated acyl donor peptide and a non-protected acyl acceptor peptide. The enzyme is derived from an earlier subtilisin variant called peptiligase by several rounds of
Externí odkaz:
https://doaj.org/article/6a85ba9608194f52a918b9a4228a5b84
Publikováno v:
Biotechnology for Biofuels, Vol 13, Iss 1, Pp 1-18 (2020)
Abstract Background Efficient bioethanol production from hemicellulose feedstocks by Saccharomyces cerevisiae requires xylose utilization. Whereas S. cerevisiae does not metabolize xylose, engineered strains that express xylose isomerase can metaboli
Externí odkaz:
https://doaj.org/article/c8ba0ea90cda4e39940ae571e707fd0b
Autor:
Siavash Atashgahi, Martin G. Liebensteiner, Dick B. Janssen, Hauke Smidt, Alfons J. M. Stams, Detmer Sipkema
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Organic and inorganic chlorine compounds are formed by a broad range of natural geochemical, photochemical and biological processes. In addition, chlorine compounds are produced in large quantities for industrial, agricultural and pharmaceutical purp
Externí odkaz:
https://doaj.org/article/f5ae1e8ba5214056a412e59e1331a261
Autor:
Linhan Dong, Qinglong Meng, Carlos Ramírez-Palacios, Hein J. Wijma, Siewert J. Marrink, Dick B. Janssen
Publikováno v:
Catalysts, Vol 10, Iss 11, p 1310 (2020)
The production of chiral amines by transaminase-catalyzed amination of ketones is an important application of biocatalysis in synthetic chemistry. It requires transaminases that show high enantioselectivity in asymmetric conversion of the ketone prec
Externí odkaz:
https://doaj.org/article/3d8423e7f6d9491fb98699cd600f0665
Publikováno v:
Muller Journal of Medical Sciences and Research, Vol 5, Iss 2, Pp 195-199 (2014)
Perampanel (2-[2-oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl] benzonitrile hydrate) is the latest antiepileptic drugs for treatment of refractory partial onset seizures. Perampanel inhibits α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic ac
Externí odkaz:
https://doaj.org/article/3aac09965abf449fa2b4c800834cfbdf
Publikováno v:
FEBS Open Bio, Vol 4, Iss C, Pp 168-174 (2014)
Enzyme stability is an important parameter in biocatalytic applications, and there is a strong need for efficient methods to generate robust enzymes. We investigated whether stabilizing disulfide bonds can be computationally designed based on a model
Externí odkaz:
https://doaj.org/article/8018133a895f4a30b8af3178e5625c4d
Publikováno v:
Muller Journal of Medical Sciences and Research, Vol 5, Iss 2, Pp 152-154 (2014)
Clostridium difficile-associated diarrhea (CDAD) occurs commonly as a side effect of broad-spectrum antibiotics. Drugs approved for CDAD are only two of them, metronidazole and vancomycin. Most promising drug for treatment of CDAD is vancomycin, but
Externí odkaz:
https://doaj.org/article/9c5b6b21dfab4808ac290b765e943cb4