Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Dibromophakellstatin"'
Autor:
Poullennec, Karine
Marine natural products biogenetically derived from the pyrrole-imidazole oroidin (i) display fascinating structural diversity and exhibit a wide range of significant biological activities. Hence, they have attracted great interest from the synthetic
Externí odkaz:
http://hdl.handle.net/1969.1/1165
Autor:
Jetze J. Tepe, Shun Su, Ken S. Feldman, Amanda P. Skoumbourdis, Matthew D. Fodor, Ian B. Seiple, Theresa A. Lansdell, Nicole M. Hewlett, Phil S. Baran
Publikováno v:
Journal of Natural Products. 75:980-985
We report herein that the oroidin-derived alkaloids palau'amine (1), dibromophakellin (2), and dibromophakellstatin (3) inhibit the proteolytic activity of the human 20S proteasome as well as the (i)20S immunoproteasome catalytic core. Palau'amine is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1086015ee96ec9715b13d2a648e483f8
https://doi.org/10.1021/np300231f
https://doi.org/10.1021/np300231f
Publikováno v:
Chemistry - An Asian Journal. 5:1810-1816
A new method for the preparation of quaternary chiral aminals has been developed that employs an enamide-type Overman rearrangement process. This methodology was applied to enantioselective total syntheses of (+)-dibromophakellin and (+)-dibromophake
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91db92e39865c0065b04409d2a9f1ff4
https://doi.org/10.1002/asia.201000213
https://doi.org/10.1002/asia.201000213
Publikováno v:
Synthesis. 2009:3162-3173
A putative biosynthesis proposal for oroidin-derived marine alkaloids serves as a template for developing a biomimetic strategy for the syntheses of tetracyclic members of the phakellin family of sponge metabolites. Pummerer chemistry triggers the ox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cf250378d4cb70e41313e510d5b587b
https://doi.org/10.1055/s-0029-1216939
https://doi.org/10.1055/s-0029-1216939
Publikováno v:
Tetrahedron Letters. 43:3699-3702
The dipyrrolopyrazinone (ABC) core of the phakelline-type pyrrole–imidazole alkaloids from marine sponges was synthesized starting from l -prolinol and 2-trichloroacetylated pyrroles. On oxidation of the condensation product with IBX, immediate cyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ca876893bcf9079856abfb1c98b14bc
https://doi.org/10.1016/s0040-4039(02)00600-7
https://doi.org/10.1016/s0040-4039(02)00600-7
Autor:
Mazurais, Marie
Les transferts de nitrène représentent un outil synthétique très intéressant pour former simplement une liaison C-N à partir d’une liaison C-H. Notre laboratoire a développé des précurseurs de nitrène chiraux : les sulfonimidamides. Leur
Externí odkaz:
http://www.theses.fr/2014PA112257/document
Autor:
Mazurais, Marie
Publikováno v:
Chimie organique. Université Paris Sud-Paris XI, 2014. Français. ⟨NNT : 2014PA112257⟩
Catalytic nitrene transfers are useful tools in organic synthesis for the efficient conversion of a C-H bond into a C-N bond. In this context, our group has recently reported the use of sulfonimidamides as efficient chiral nitrene precursors in the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::718de213d25b224895875f6c27cfdd1e
https://tel.archives-ouvertes.fr/tel-01214233/document
https://tel.archives-ouvertes.fr/tel-01214233/document
Publikováno v:
Synlett. 2007:2756-2758
The antitumor active pyrrole-imidazole alkaloid (-)-dibromophakellstatin from the marine sponge PHAKELLIA MAURITIANA was synthesized enantioselectively in ten steps, starting from -hydroxyproline. The key step is the diastereoselective three-componen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9703bd4cf844335b335c2bb134f1104
https://doi.org/10.1055/s-2007-986664
https://doi.org/10.1055/s-2007-986664
Publikováno v:
ChemInform. 44
Oroidin derived, pyrrole imidazole marine alkaloids (PIAs) are attractive targets for synthetic organic chemists because of their structural complexity and diversity, as well as their interesting biological activities. A number of efforts have been c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00353d16034008f48ea1488b025f3cf8
https://doi.org/10.1002/chin.201349242
https://doi.org/10.1002/chin.201349242
Publikováno v:
Natural product communications. 8(7)
Oroidin derived pyrrole imidazole marine alkaloids (PIAs) are attractive targets for synthetic organic chemists because of their structural complexity and diversity as well as their interesting biological activities. A number of efforts have been car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c15342bfcfbf76e765a3fb60f8b377
https://pubmed.ncbi.nlm.nih.gov/23980430
https://pubmed.ncbi.nlm.nih.gov/23980430