Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Diaz-Uriarte Ramon"'
Autor:
Renz, Jessica, Dauda, Kazeem A., Aga, Olav N. L., Diaz-Uriarte, Ramon, Löhr, Iren H., Blomberg, Bjørn, Johnston, Iain G.
Can we understand and predict the evolutionary pathways by which bacteria acquire multi-drug resistance (MDR)? These questions have substantial potential impact in basic biology and in applied approaches to address the global health challenge of anti
Externí odkaz:
http://arxiv.org/abs/2411.00219
Autor:
Diaz-Uriarte, Ramon, Johnston, Iain G.
Cancer progression and monotonic accumulation models were developed to discover dependencies in the irreversible acquisition of binary traits from cross-sectional data. They have been used in computational oncology and virology but also in widely dif
Externí odkaz:
http://arxiv.org/abs/2312.06824
Autor:
Diaz-Colunga, Juan, Skwara, Abigail, Gowda, Karna, Diaz-Uriarte, Ramon, Tikhonov, Mikhail, Bajic, Djordje, Sanchez, Alvaro
Epistatic interactions between mutations add substantial complexity to adaptive landscapes, and are often thought of as detrimental to our ability to predict evolution. Yet, patterns of global epistasis, in which the fitness effect of a mutation is w
Externí odkaz:
http://arxiv.org/abs/2210.03677
Autor:
Manrubia, Susanna, Cuesta, José A., Aguirre, Jacobo, Ahnert, Sebastian E., Altenberg, Lee, Cano, Alejandro V., Catalán, Pablo, Diaz-Uriarte, Ramon, Elena, Santiago F., García-Martín, Juan Antonio, Hogeweg, Paulien, Khatri, Bhavin S., Krug, Joachim, Louis, Ard A., Martin, Nora S., Payne, Joshua L., Tarnowski, Matthew J., Weiß, Marcel
Publikováno v:
Physics of Life Reviews 38, 55-106 (2021)
Understanding how genotypes map onto phenotypes, fitness, and eventually organisms is arguably the next major missing piece in a fully predictive theory of evolution. We refer to this generally as the problem of the genotype-phenotype map. Though we
Externí odkaz:
http://arxiv.org/abs/2002.00363
Publikováno v:
BMC Medical Genomics, Vol 4, Iss 1, p 47 (2011)
Abstract Background Copy number variants (CNV) are a potentially important component of the genetic contribution to risk of common complex diseases. Analysis of the association between CNVs and disease requires that uncertainty in CNV copy-number cal
Externí odkaz:
https://doaj.org/article/7be4375c030d4b679d49ff7d94afed26
Autor:
Diaz-Uriarte Ramon, Rueda Oscar M
Publikováno v:
BMC Bioinformatics, Vol 10, Iss 1, p 308 (2009)
Abstract Background Alterations in the number of copies of genomic DNA that are common or recurrent among diseased individuals are likely to contain disease-critical genes. Unfortunately, defining common or recurrent copy number alteration (CNA) regi
Externí odkaz:
https://doaj.org/article/b2078a9526a047e8a9fab9f27a16595c
Autor:
Diaz-Uriarte Ramon
Publikováno v:
BMC Bioinformatics, Vol 9, Iss 1, p 30 (2008)
Abstract Background Censored data are increasingly common in many microarray studies that attempt to relate gene expression to patient survival. Several new methods have been proposed in the last two years. Most of these methods, however, are not ava
Externí odkaz:
https://doaj.org/article/55f5e9e92fb34a069ba1495fea3bb786
Autor:
Diaz-Uriarte Ramon, Rueda Oscar M
Publikováno v:
BMC Bioinformatics, Vol 8, Iss 1, p 394 (2007)
Abstract Background Yu et al. (BMC Bioinformatics 2007,8: 145+) have recently compared the performance of several methods for the detection of genomic amplification and deletion breakpoints using data from high-density single nucleotide polymorphism
Externí odkaz:
https://doaj.org/article/ebc24e2b254e48dbbdf80d8ce9e95ad1
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Autor:
Manrubia, Susanna, Cuesta, José A., Aguirre, Jacobo, Ahnert, Sebastian E., Altenberg, Lee, Cano, Alejandro V., Catalán, Pablo, Diaz-Uriarte, Ramon, Elena, Santiago F., García-Martín, Juan Antonio, Hogeweg, Paulien, Khatri, Bhavin S., Krug, Joachim, Louis, Ard A., Martin, Nora S., Payne, Joshua L., Tarnowski, Matthew J., Weiß, Marcel
Publikováno v:
In Physics of Life Reviews September 2021 38:55-106