Single-nucleus RNA/ATAC-seq in early-stage HCM models predicts SWI/SNF-activation in mutant-myocytes, and allele-specific differences in fibroblasts.

Autor: Thottakara T; Department of Medicine, University of California San Francisco, Division of Cardiology, San Francisco.; Department of Cardiology, University Heart and Vascular Center Hamburg, Germany., Padmanabhan A; Department of Medicine, University of California San Francisco, Division of Cardiology, San Francisco.; Gladstone Institutes, San Francisco, CA, USA., Tanriverdi T; Department of Medicine, University of California San Francisco, Division of Cardiology, San Francisco., Thambidurai T; Department of Medicine, University of California San Francisco, Division of Cardiology, San Francisco., Diaz-Rg JA; Department of Medicine, University of California San Francisco, Division of Cardiology, San Francisco., Amonkar SR; Department of Medicine, University of California San Francisco, Division of Cardiology, San Francisco., Olgin JE; Department of Medicine, University of California San Francisco, Division of Cardiology, San Francisco., Long CS; Department of Medicine, University of California San Francisco, Division of Cardiology, San Francisco., Roselle Abraham M; Department of Medicine, University of California San Francisco, Division of Cardiology, San Francisco.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Apr 24. Date of Electronic Publication: 2024 Apr 24.