A new HPLC-MS/MS method for the simultaneous quantification of SGLT2 inhibitors and metformin in plasma and its application to a pharmacokinetic study in healthy volunteers.

Autor: Dias BCL; Department of Pharmacy, Federal University of Parana, Curitiba, Paraná, Brazil., Fachi MM; Department of Pharmacy, Federal University of Parana, Curitiba, Paraná, Brazil., de Campos ML; Federal University of Mato Grosso, Health Sciences Institute, Sinop, MT, Brazil., Degaut FLD; Department of Pharmacy, Federal University of Parana, Curitiba, Paraná, Brazil., Peccinini RG; Department of Natural Active Principles and Toxicology, São Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, Brazil., Pontarolo R; Department of Pharmacy, Federal University of Parana, Curitiba, Paraná, Brazil.

Publikováno v: Biomedical chromatography : BMC [Biomed Chromatogr] 2019 Nov; Vol. 33 (11), pp. e4663. Date of Electronic Publication: 2019 Sep 05.