Výsledky vyhledávání - "Dias, Marcio VB"

Fragment-Merging Strategies with Known Pyrimidine Scaffolds Targeting Dihydrofolate Reductase from Mycobacterium tuberculosis

Autor: Kirkman, Tim, Fun Tan, Suk, Chavez-Pacheco, Sair Maximo, Hammer, Alexander, Abell, Chris, Tosin, Manuela, Coyne, Anthony G, Dias, Marcio VB

Dihydrofolate reductase (DHFR) is a key enzyme involved in the folate pathway that has been heavily targeted for the development of therapeutics against cancer and bacterial and protozoa infections amongst others. Despite being an essential enzyme fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::166a262d1f32a0a6e52bdba26dd147a9
https://www.repository.cam.ac.uk/handle/1810/350042

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Chemical validation of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase using fragment linking and CRISPR interference

Autor: El Bakali, Jamal, Blaszczyk, Michal, Evans, Joanna C, Boland, Jennifer A, McCarthy, William J, Fathoni, Imam, Dias, Marcio VB, Johnson, Eachan O, Coyne, Anthony G, Mizrahi, Valerie, Blundell, Tom L, Abell, Chris, Spry, Christina

The coenzyme A (CoA) biosynthesis pathway has attracted attention as a potential target for much-needed novel antimicrobial drugs, including for the treatment of tuberculosis (TB), the lethal disease caused by Mycobacterium tuberculosis (Mtb). Seekin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a0340efc1b35f3286ca53d4280a9e1a

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Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK

Autor: Dias, Marcio VB, Huang, Fanglu, Chirgadze, Dimitri Y, Tosin, Manuela, Spiteller, Dieter, Dry, Emily FV, Leadlay, Peter F, Spencer, Jonathan B, Blundell, Tom L

The thioesterase FlK from the fluoroacetate-producing Streptomyces cattleya catalyzes the hydrolysis of fluoroacetyl-coenzyme A. This provides an effective self-defense mechanism, preventing any fluoroacetyl-coenzyme A formed from being further metab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b5043ce158ba35b089ad1b44835d857d

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Enzyme-Catalyzed Spiroacetal Formation in Polyketide Antibiotic Biosynthesis

Autor: Oksana Bilyk, Gabriel S. Oliveira, Rafaela M. de Angelo, Michell O. Almeida, Kathia Maria Honório, Finian J. Leeper, Marcio V. B. Dias, Peter F. Leadlay

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

A key step in the biosynthesis of numerous polyketides is the stereospecific formation of a spiroacetal (spiroketal). We report here that spiroacetal formation in the biosynthesis of the macrocyclic polyketides ossamycin and oligomycin involves catal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b13863750d42f4599cb4b00d6cf31915
https://doi.org/10.1021/jacs.2c03313

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