Výsledky vyhledávání - "Diarmuid M. Moran"

Akademický článek

Microencapsulation of Engineered Cells to Deliver Sustained High Circulating Levels of Interleukin-6 to Study Hepatocellular Carcinoma Progression

Autor: Diarmuid M. Moran, Leonidas G. Koniaris, Elizabeth M. Jablonski, Paul A. Cahill, Craig R. Halberstadt, Iain H. Mckillop

Publikováno v: Cell Transplantation, Vol 15 (2006)

Interlukin-6 (IL-6) is a pleitropic cytokine that plays a central role in normal and abnormal hepatic function and response. The aims of the current study were to determine the viability of using cell encapsulation technology to introduce a genetical

Externí odkaz: https://doaj.org/article/927f9157d339441a85bea68011d6c9d8

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Data from KRAS Mutation Status Is Associated with Enhanced Dependency on Folate Metabolism Pathways in Non–Small Cell Lung Cancer Cells

Autor: Sarah S. Bacus, David Sidransky, Keren Paz, Karen Pry, Patricia B. Trusk, Diarmuid M. Moran

KRAS gene mutation is linked to poor prognosis and resistance to therapeutics in non–small cell lung cancer (NSCLC). In this study, we have explored the possibility of exploiting inherent differences in KRAS-mutant cell metabolism for treatment. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6224b879257a08264438939e97acf6d
https://doi.org/10.1158/1535-7163.c.6536542.v1

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Supplementary Table 2 from KRAS Mutation Status Is Associated with Enhanced Dependency on Folate Metabolism Pathways in Non–Small Cell Lung Cancer Cells

Autor: Sarah S. Bacus, David Sidransky, Keren Paz, Karen Pry, Patricia B. Trusk, Diarmuid M. Moran

PDF - 68K, Normalized basal gene expression microarray data for non-squamous NSCLC NCI60 cell lines were grouped according to KRAS mutation status. Genes showing significant differences in expression between KRAS mutant and KRAS wildtype cells were a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a52000bf10937f7e1bb188611ab2d0f9
https://doi.org/10.1158/1535-7163.22500685

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Supplementary Table 1 from KRAS Mutation Status Is Associated with Enhanced Dependency on Folate Metabolism Pathways in Non–Small Cell Lung Cancer Cells

Autor: Sarah S. Bacus, David Sidransky, Keren Paz, Karen Pry, Patricia B. Trusk, Diarmuid M. Moran

PDF - 75K, Normalized basal gene expression microarray data for non-squamous NSCLC NCI60 cell lines were grouped according to KRAS mutation status. Genes showing significant differences in expression between KRAS mutant and KRAS wildtype cells were a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32970d1854abf60ef96c4f6544ff989a
https://doi.org/10.1158/1535-7163.22500688.v1

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Supplementary Table 3 from KRAS Mutation Status Is Associated with Enhanced Dependency on Folate Metabolism Pathways in Non–Small Cell Lung Cancer Cells

Autor: Sarah S. Bacus, David Sidransky, Keren Paz, Karen Pry, Patricia B. Trusk, Diarmuid M. Moran

PDF - 69K, Normalized basal gene expression microarray data for non-squamous NSCLC NCI60 cell lines were grouped according to KRAS mutation status. Genes showing significant differences in expression between KRAS mutant and KRAS wildtype cells were a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::103fa5a94022bf8a7d1b9ac3883e907d
https://doi.org/10.1158/1535-7163.22500682.v1

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Data from Nutlin-3a Induces Cytoskeletal Rearrangement and Inhibits the Migration and Invasion Capacity of p53 Wild-Type Cancer Cells

Autor: Carl G. Maki, Diarmuid M. Moran

MDM2 is an E3 ubiquitin ligase that binds and ubiquitinates the tumor suppressor protein p53, leading to its proteasomal degradation. Nutlin-3a (Nutlin) is a preclinical drug that binds MDM2 and prevents the interaction between MDM2 and p53, leading

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77a06a616769602da29ecc0569a7aed6
https://doi.org/10.1158/1535-7163.c.6532196

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