Comparison of dissolution testing methods for the 25 mg dapivirine vaginal ring

Autor: Karl Malcolm, Clare McCoy, Diarmaid Murphy, Peter Boyd, Tiffany Derrick, Patrick Spence, Brid Devlin

Publikováno v: Malcolm, R, McCoy, C, Murphy, D, Boyd, P, Derrick, T, Spence, P & Devlin, B 2018, ' Comparison of dissolution testing methods for the 25 mg dapivirine vaginal ring ' HIV Research for Prevention 2018, Madrid, Spain, 21/10/2018-25/10/2018, .
Queen's University Belfast-PURE

Background: Dissolution testing of the 25 mg dapivirine (DPV) vaginal ring has historically relied on a non-compendial shaking incubator method. Typically, individual rings in a sealed glass flask containing a defined volume of release medium are pla

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https://pure.qub.ac.uk/portal/en/publications/comparison-of-dissolution-testing-methods-for-the-25-mg-dapivirine-vaginal-ring(6a50f44e-4074-47ad-9941-a2cd7a1d447f).html

Fleet Purchasing, Maintenance and Reliability

Autor: Diarmaid Murphy

OverviewFleet Purchasing and Maintenance is a concise, easy to understand guide on vehicle purchasing and fleet maintenance for the benefit of business and maintenance managers at all levels, plus students and academics. Not a textbook full of formu

Effect of exposure of the 25 mg dapivirine vaginal ring to cleaning solutions and personal lubricants

Autor: Diarmaid Murphy, Clare McCoy, Peter Boyd, Tiffany Derrick, Patrick Spence, Brid Devlin, Karl Malcolm

Publikováno v: Queen's University Belfast-PURE
Murphy, D, McCoy, C F, Boyd, P, Derrick, T, Spence, P, Devlin, B & Malcolm, R 2018, ' Effect of exposure of the 25 mg dapivirine vaginal ring to cleaning solutions and personal lubricants ' HIV Research for Prevention 2018, Madrid, Spain, 21/10/2018-25/10/2018, .

Background: During use, vaginal rings may be exposed to various cleaning agents or personal lubricants which have the potential to extract drug from the ring, cause ring discoloration, and/or cause degradation of the drug substance within the ring. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::128c442fc96ab10ed2531d63348e7435
https://pure.qub.ac.uk/en/publications/8af3fcb6-6961-4acf-96de-6fc3236b93c9

Thermal properties and eutectic behaviour of dapivirine in combination with steroid hormones and other antiretrovirals

Autor: Karl Malcolm, Clare McCoy, Diarmaid Murphy, Peter Boyd, Sandeep Kumar, Susan Fetherston, Andrew Brimer, Jonathon Holt, Brid Devlin, Wendy Blanda, Jeremy Nuttall, Chris Gilmour

Publikováno v: Queen's University Belfast-PURE
Malcolm, K, McCoy, C, Murphy, D, Boyd, P, Kumar, S, Fetherston, S, Brimer, A, Holt, J, Devlin, B, Blanda, W, Nuttall, J & Gilmour, C 2014, ' Thermal properties and eutectic behaviour of dapivirine in combination with steroid hormones and other antiretrovirals ' HIV R4P-HIV Research for Prevention, Cape Town, South Africa, 28/10/2014-31/10/2014, .

Background: Combination drug products can display thermal behaviour that is more complex than for the corresponding single drug products. For example, the contraceptive vaginal ring (VR) Nuvaring contains a eutectic (lowest melting) composition of et

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::171fe3c99145b804a08103b95a0731cf
https://pure.qub.ac.uk/en/publications/14cfe93f-1f00-4020-abce-1937e3ba4f5b

In vitro modelling of in vivo discoloration of the dapivirine-levonorgestrel vaginal ring using a range of simulated vaginal and menstrual fluids

Autor: Clare McCoy, Diarmaid Murphy, Yahya H. Dallal Bashi, Peter Boyd, Pat Spence, Brid Devlin, Kyle Kleinbeck, Bindi Dangi, Tiffany Derrick, Karl Malcolm

Publikováno v: Queen's University Belfast-PURE
McCoy, C F, Murphy, D J, Dallal Bashi, Y H, Boyd, P, Spence, P, Devlin, B, Kleinbeck, K, Dangi, B, Derrick, T & Malcolm, R K 2021, ' In vitro modelling of in vivo discoloration of the dapivirine-levonorgestrel vaginal ring using a range of simulated vaginal and menstrual fluids ', 4th HIV Research for Prevention Conference (HIVR4P // Virtual), 27/01/2021-04/02/2021 .

BackgroundDuring clinical trials of the dapivirine+levonorgestrel (DPV+LNG) silicone VR, surface discoloration was observed on some ring samples. To investigate the potential causes of this discoloration, four different silicone VR formulations were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2da6be672ccaee934803ad96c18f1588
https://pure.qub.ac.uk/en/publications/bcf8474b-0efc-41f4-830f-105f00c2bbc1