Use of simulated vaginal and menstrual fluids to model in vivo discolouration of silicone elastomer vaginal rings

Autor: Clare F. McCoy, Patrick Spence, Yahya H. Dallal Bashi, Diarmaid J. Murphy, Peter Boyd, Bindi Dangi, Tiffany Derrick, Bríd Devlin, Kyle Kleinbeck, R. Karl Malcolm

Publikováno v: International Journal of Pharmaceutics: X, Vol 3, Iss , Pp 100081- (2021)

Vaginal rings releasing antiretrovirals – either alone or in combination with contraceptive progestins – are being developed for prevention of human immunodeficiency virus (HIV) transmission via vaginal sex. Following Phase I trials, significant

Externí odkaz: https://doaj.org/article/33201504c4cc4078bdec85999ffab7fe

Refining the in vitro release test method for a dapivirine-releasing vaginal ring to match in vivo performance

Autor: R. Karl Malcolm, Deanna Lim, Ryan Armstrong, Peter Boyd, Yahya H. Dallal Bashi, Diarmaid J. Murphy, Tiffany Derrick, Clare McCoy, Patrick Spence, Brid Devlin

Publikováno v: Murphy, D J, Lim, D, Armstrong, R, McCoy, C F, Dallal Bashi, Y, Boyd, P, Derrick, T, Spence, P, Devlin, B & Malcolm, K 2021, ' Refining the in vitro release test method for a dapivirine-releasing vaginal ring to match in vivo performance ', Drug Delivery and Translational Research . https://doi.org/10.1007/s13346-021-01081-7

Previously reported in vitro release test methods for drug-releasing vaginal rings containing poorly water-soluble drugs have described use of water-alcohol systems or surfactant solutions in efforts to maintain sink conditions. Here, as part of effo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a4745feb9d3b4ba3523790aed18915
https://doi.org/10.1007/s13346-021-01081-7

Silicone elastomer formulations for improved performance of a multipurpose vaginal ring releasing dapivirine and levonorgestrel

Autor: Bashir Hansraj, Patrick Spence, Diarmaid J. Murphy, Brid Devlin, Kyle Kleinbeck, R. Karl Malcolm, Bindi Dangi, Peter Boyd, Matthew Kihara, Clare McCoy, Nicole McMullen, Leeanne Brown, Yahya H. Dallal Bashi, Francois Martin

Publikováno v: International Journal of Pharmaceutics: X, Vol 3, Iss, Pp 100091-(2021)
International Journal of Pharmaceutics: X
Dallal Bashi, Y H, Murphy, D J, McCoy, C F, Boyd, P, Brown, L, Kihara, M, Martin, F, McMullen, N, Kleinbeck, K, Dangi, B, Spence, P, Hansraj, B, Devlin, B & Malcolm, R K 2021, ' Silicone elastomer formulations for improved performance of a multipurpose vaginal ring releasing dapivirine and levonorgestrel ', International Journal of Pharmaceutics: X, vol. 3, 100091 . https://doi.org/10.1016/j.ijpx.2021.100091

A dapivirine-releasing silicone elastomer vaginal ring for reducing women's risk of HIV acquisition has recently been approved. A next-generation multipurpose vaginal ring releasing dapivirine and levonorgestrel is currently in development, offering

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de38dbedfa67eab5fc840a0342ea6e47
https://doi.org/10.1016/j.ijpx.2021.100091

Mechanical testing methods for drug-releasing vaginal rings

Autor: Clare McCoy, Wendy Blanda, Bronagh Millar, Bashir Hansraj, Brid Devlin, R. Karl Malcolm, Diarmaid J. Murphy, Peter Boyd

Publikováno v: McCoy, C F, Millar, B G, Murphy, D J, Blanda, W, Hansraj, B, Devlin, B, Malcolm, R K & Boyd, P 2019, ' Mechanical testing methods for drug-releasing vaginal rings ', International Journal of Pharmaceutics, vol. 559, pp. 182-191 . https://doi.org/10.1016/j.ijpharm.2019.01.026

Vaginal rings (VRs) are currently marketed for contraceptive or hormone regulation purposes, and investigationally, have been widely reported for delivery of antiretrovirals to reduce HIV transmission. To date, there is no national or international s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13beeaa537d59538289e26b920b2849f
https://pure.qub.ac.uk/en/publications/mechanical-testing-methods-for-drugreleasing-vaginal-rings(09e068c9-c24e-4050-b791-e61527d6d9a2).html

Microbicide vaginal rings: Technological challenges and clinical development

Autor: Diarmaid J. Murphy, Clare McCoy, Peter Boyd, R. Karl Malcolm

Publikováno v: Malcolm, R K, Boyd, P J, McCoy, C F & Murphy, D J 2016, ' Microbicide Vaginal Rings: Technological Challenges and Clinical Development ', Advanced Drug Delivery Reviews, vol. 103, pp. 33-56 . https://doi.org/10.1016/j.addr.2016.01.015

Vaginal rings (VRs) are flexible, torus-shaped, polymeric devices designed to sustain delivery of pharmaceutical drugs to the vagina for clinical benefit. Following first report in a 1970 patent application, several steroid-releasing VR products have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9f54d6ea75f89d9db762afcf38db3af
https://doi.org/10.1016/j.addr.2016.01.015