Zobrazeno 1 - 10
of 206
pro vyhledávání: '"Diarmaid, Hughes"'
Autor:
Chenyan Zhao, Anders N. Kristoffersson, David D. Khan, Pernilla Lagerbäck, Ulrika Lustig, Sha Cao, Charlotte Annerstedt, Otto Cars, Dan I. Andersson, Diarmaid Hughes, Elisabet I. Nielsen, Lena E. Friberg
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Co-administering a low dose of colistin (CST) with ciprofloxacin (CIP) may improve the antibacterial effect against resistant Escherichia coli, offering an acceptable benefit-risk balance. This study aimed to quantify the interaction between
Externí odkaz:
https://doaj.org/article/d0ef7f77c98649738aac192f0a70cea9
Autor:
Diarmaid Hughes, Ali Aminian, Chao Tu, Yuichiro Okushi, Yoshihito Saijo, Rickesha Wilson, Nicholas Chan, Ashwin Kumar, Richard A. Grimm, Brian P. Griffin, W. H. Wilson Tang, Steven E. Nissen, Bo Xu
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 1 (2024)
Background Obesity leads to an increased risk of cardiovascular disease morbidity and death, including heart failure. Bariatric surgery has been proven to be the most effective long‐term weight management treatment. This study investigated the chan
Externí odkaz:
https://doaj.org/article/41be5a607390422aa8dbc44e4bf4cf25
Autor:
Robert P. Murphy, Martin J. O’Donnell, Aoife Nolan, Emer McGrath, Aengus O’Conghaile, John Ferguson, Alberto Alvarez‐Iglesias, Maria Costello, Elaine Loughlin, Catriona Reddin, Sarah Ruttledge, Sarah Gorey, Diarmaid Hughes, Andrew Smyth, Michelle Canavan, Conor Judge
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 20 (2022)
Background A run‐in period may increase adherence to intervention and reduce loss to follow‐up. Whether use of a run‐in period affects the magnitude of treatment effects is unknown. Methods and Results We conducted a meta‐analysis comparing t
Externí odkaz:
https://doaj.org/article/171e521142744aaf983938d4b8f09795
Autor:
Rakel Arrazuria, Bernhard Kerscher, Karen E. Huber, Jennifer L. Hoover, Carina Vingsbo Lundberg, Jon Ulf Hansen, Sylvie Sordello, Stephane Renard, Vincent Aranzana-Climent, Diarmaid Hughes, Philip Gribbon, Lena E. Friberg, Isabelle Bekeredjian-Ding
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
The rise in antimicrobial resistance (AMR), and increase in treatment-refractory AMR infections, generates an urgent need to accelerate the discovery and development of novel anti-infectives. Preclinical animal models play a crucial role in assessing
Externí odkaz:
https://doaj.org/article/4b5b6c8d81a04eadbeb5ed8b76a1c875
Autor:
Rakel Arrazuria, Bernhard Kerscher, Karen E. Huber, Jennifer L. Hoover, Carina Vingsbo Lundberg, Jon Ulf Hansen, Sylvie Sordello, Stephane Renard, Vincent Aranzana-Climent, Diarmaid Hughes, Philip Gribbon, Lena E. Friberg, Isabelle Bekeredjian-Ding
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Antimicrobial resistance has become one of the greatest threats to human health, and new antibacterial treatments are urgently needed. As a tool to develop novel therapies, animal models are essential to bridge the gap between preclinical and clinica
Externí odkaz:
https://doaj.org/article/cee7cdc3abe644f0b3323bf66538e83e
Autor:
Katja Becker, Sha Cao, Anna Nilsson, Maria Erlandsson, Sven-Kevin Hotop, Janis Kuka, Jon Hansen, Klara Haldimann, Solveiga Grinberga, Talia Berruga-Fernández, Douglas L. Huseby, Reza Shariatgorji, Evelina Lindmark, Björn Platzack, Erik C. Böttger, David Crich, Lena E. Friberg, Carina Vingsbo Lundberg, Diarmaid Hughes, Mark Brönstrup, Per E. Andrén, Edgars Liepinsh, Sven N. Hobbie
Publikováno v:
EBioMedicine, Vol 73, Iss , Pp 103652- (2021)
Background: The clinical-stage drug candidate EBL-1003 (apramycin) represents a distinct new subclass of aminoglycoside antibiotics for the treatment of drug-resistant infections. It has demonstrated best-in-class coverage of resistant isolates, and
Externí odkaz:
https://doaj.org/article/b25c8a267d4642389bf6d5a2908a5a98
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
Bacterial chromosomes frequently carry multiple copies of genes at separate chromosomal locations. In Salmonellarrntuf
Externí odkaz:
https://doaj.org/article/934ecf72646f4a4d9747649ef86fe220
Autor:
Gerrit Brandis, Diarmaid Hughes
Publikováno v:
PLoS Genetics, Vol 16, Iss 3, p e1008615 (2020)
The relative linear order of most genes on bacterial chromosomes is not conserved over evolutionary timescales. One explanation is that selection is weak, allowing recombination to randomize gene order by genetic drift. However, most chromosomal rear
Externí odkaz:
https://doaj.org/article/2d91427711b34e489d20d0d07101a0ed
Autor:
Vincent Aranzana-Climent, Diarmaid Hughes, Sha Cao, Magdalena Tomczak, Malgorzata Urbas, Dorota Zabicka, Carina Vingsbo Lundberg, Jon Hansen, Johan Lindberg, Sven N. Hobbie, Lena E. Friberg
Publikováno v:
Clinical Microbiology and Infection. 28:1367-1374
Objectives: New drugs and methods to efficiently fight carbapenem-resistant gram-negative pathogens are sorely needed. In this study, we characterized the preclinical pharmacokinetics (PK) and pharmacodynamics of the clinical stage drug candidate apr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a2582df4c2b82a4b309a3d25a8fc716
https://doi.org/10.1016/j.cmi.2022.05.003
https://doi.org/10.1016/j.cmi.2022.05.003
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Externí odkaz:
https://doaj.org/article/5c121033b67b4ef9b144d280f6385389