Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Dianxing Hu"'
Autor:
Xucui Zhuang, Rourou Xiao, Yu Fu, Bin Yang, Junpeng Fan, Funian Lu, Tianyu Qin, Xiaohang Yang, Xingyuan Hu, Jingjing Yin, Wenting Li, Xiaoyan Kang, Gang Chen, Dianxing Hu, Chaoyang Sun
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Background Although the clinical application of PARP inhibitors has brought hope to ovarian cancer, the problem of its resistance has become increasingly prominent. Therefore, clinical experts have been focused on finding specific indicators
Externí odkaz:
https://doaj.org/article/361f1e0ccb4443d29c505529b59cc7a8
Autor:
Li Zhang, Xi Li, Gang Chen, Yu Fu, Bin Yang, Wenting Li, Jingbo Liu, Xu Qin, Gordon B Mills, Yaoyuan Cui, Xingyuan Hu, Funian Lu, Tianyu Qin, Zhe Hu, Ensong Guo, Junpeng Fan, Rourou Xiao, Dianxing Hu, Wenju Peng, Beibei Wang, Chaoyang Sun
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 4 (2023)
Background Mismatch repair deficiency (dMMR) is a well-recognized biomarker for response to immune checkpoint blockade (ICB). Strategies to convert MMR-proficient (pMMR) to dMMR phenotype with the goal of sensitizing tumors to ICB are highly sought.
Externí odkaz:
https://doaj.org/article/885194f4d4ed49448a58d817aacaae43
Autor:
Junpeng Fan, Yu Fu, Wenju Peng, Xiong Li, Yuanming Shen, Ensong Guo, Funian Lu, Shengtao Zhou, Si Liu, Bin Yang, Xu Qin, Dianxing Hu, Rourou Xiao, Xi Li, Siqi Yang, Cunzhong Yuan, Yao Shu, He Huang, Ting Wan, Yanan Pi, Shuxiang Wang, Wenjuan Chen, Haixia Wang, Lin Zhong, Li Yuan, Baogang Wen, Beihua Kong, Gordon B. Mills, Dongling Zou, Bairong Xia, Kun Song, Gang Chen, Ding Ma, Chaoyang Sun
Publikováno v:
Cell Genomics, Vol 3, Iss 1, Pp 100211- (2023)
Summary: Cervical cancer (CC) that is caused by high-risk human papillomavirus (HPV) remains a significant public health problem worldwide. HPV integration sites can be silent or actively transcribed, leading to the production of viral-host fusion tr
Externí odkaz:
https://doaj.org/article/bff3c82c7b0c42a981e3527afcfa2e4e
Autor:
Bin Yang, Junpeng Fan, Jia Huang, Ensong Guo, Yu Fu, Si Liu, Rourou Xiao, Chen Liu, Funian Lu, Tianyu Qin, Chao He, Zizhuo Wang, Xu Qin, Dianxing Hu, Lixin You, Xi Li, Tian Wang, Peng Wu, Gang Chen, Jianfeng Zhou, Kezhen Li, Chaoyang Sun
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Some patients with COVID-19 fail to clear the viral infection quickly, yet our understanding for the underlying immune characteristics is still lacking. Here the authors use single-cell RNA sequencing and other data form such patients to show that pe
Externí odkaz:
https://doaj.org/article/5c052d51218d4e68bc4f705fd39765ae
Autor:
Chen Liu, Yuhan Huang, Yaoyuan Cui, Jun Zhou, Xu Qin, Li Zhang, Xi Li, Yuan Li, Ensong Guo, Bin Yang, Junpeng Fan, Xiong Li, Yu Fu, Si Liu, Dianxing Hu, Rourou Xiao, Zizhuo Wang, Yingyu Dou, Wei Wang, Wenting Li, Xiaohang Yang, Jingbo Liu, Wenju Peng, Tianyu Qin, Lixin You, Funian Lu, Chaoyang Sun
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
BackgroundOvarian cancer (OC) is one of the most lethal gynecologic cancers. Growing evidence has proven that CDK4/6 plays a key role in tumor immunity and the prognosis of many cancers. However, the expression and function of CDK4/6 in OC remain unc
Externí odkaz:
https://doaj.org/article/a636ababc6a64413af6537f4a8671fdb
Autor:
Wei Wang, Yuxuan Xiong, Xingyuan Hu, Funian Lu, Tianyu Qin, Li Zhang, Ensong Guo, Bin Yang, Yu Fu, Dianxing Hu, JunPeng Fan, Xu Qin, Chen Liu, RouRou Xiao, Gang Chen, Zifu Li, Chaoyang Sun
Publikováno v:
Acta Biomaterialia. 157:428-441
Ovarian cancer (OC) ranks first among gynecologic malignancies in terms of mortality. The benefits of poly (ADP-ribose) polymerase (PARP) inhibitors appear to be limited to OC with BRCA mutations. Concurrent administration of WEE1 inhibitors (eg, ada
Autor:
Dianxing Hu, Ensong Guo, Bin Yang, Xu Qin, Yu Fu, Junpeng Fan, Xucui Zhuang, Qianqian Yao, Funian Lu, Wenting Li, Rourou Xiao, Xue Wu, Xiaohang Yang, Zizhuo Wang, Chen Liu, Lixin You, Rongyu Zang, Qi Zhou, Weidong Zhao, Gang Chen, Chaoyang Sun
Publikováno v:
Cancer Science. 113:2849-2861
Although resistance to poly(ADP-ribose) polymerase inhibitors (PARPi) has gradually become a major challenge in the maintenance therapy for high-grade serous ovarian carcinoma (HGSOC), there are no universal indicators for resistance monitoring in pa
Autor:
Xu Qin, Jianglin Zhou, Zizhuo Wang, Chenzhao Feng, Junpeng Fan, Jia Huang, Dianxing Hu, Babak Baban, Shengqi Wang, Ding Ma, Chaoyang Sun, Zhe Zhou, Gang Chen
Publikováno v:
EPMA Journal. 13:487-498
Purpose We investigated whether ovarian cancer could alter the genital microbiota in a specific way with clinical values. Furthermore, we proposed how such changes could be envisioned in a paradigm of predictive, preventive, and personalized medicine
Autor:
Xiaoxiao Zhang, Dianxing Hu, Wan Xie, Jiedong Jia, Changyu Wang, Fuxia Li, Wenju Peng, Lili Guo, Xu Qin, Xue Wu, Yu Fu, Xiaoyan Kang, Ensong Guo, Xiaoyu Liu, Yue Su
Publikováno v:
Cancer Science
WEE1 plays an important role in the regulation of cell cycle G2/M checkpoints and DNA damage response (DDR). Inhibition of WEE1 can increase the instability of the genome and have anti–tumor effects in some solid tumors. However, it has certain lim
Autor:
Yu Fu, Bin Yang, Yaoyuan Cui, Xingyuan Hu, Xi Li, Funian Lu, Tianyu Qin, Li Zhang, Zhe Hu, Ensong Guo, Junpeng Fan, Rourou Xiao, Wenting Li, Xu Qin, Dianxing Hu, Wenju Peng, Jingbo Liu, Beibei Wang, Gordon B Mills, Gang Chen, Chaoyang Sun
Publikováno v:
Journal for ImmunoTherapy of Cancer. 11:e006070
BackgroundMismatch repair deficiency (dMMR) is a well-recognized biomarker for response to immune checkpoint blockade (ICB). Strategies to convert MMR-proficient (pMMR) to dMMR phenotype with the goal of sensitizing tumors to ICB are highly sought. T