Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Dianne O. Hardy"'
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 119:135-140
Transgenic expression of the human angiotensinogen (HAGT) gene directed by the mouse kidney androgen-regulated protein (Kap) gene promoter is proximal tubule cell-specific and androgen-regulated in vivo. The same Kap promoter fragment did not support
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::928e4298a4cda25f0c07ad720033ba90
https://doi.org/10.1016/j.jsbmb.2010.02.005
https://doi.org/10.1016/j.jsbmb.2010.02.005
Autor:
Barry R. Zirkin, Dianne O. Hardy, Qing Quan Lian, Guo Rong Chen, Han Lin, Bing Bing Chen, Guo-Xin Hu, Ren Shan Ge
Publikováno v:
Journal of Andrology. 31:379-387
Deletion of the insulin-like growth factor 1 (Igf1) gene was shown in previous studies to result in reduced numbers of Leydig cells in the testes of 35-day-old mice, and in reduced circulating testosterone levels. In the current study, we asked wheth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d73b060fe8e261f04efc09ef069d7c96
https://doi.org/10.2164/jandrol.109.008680
https://doi.org/10.2164/jandrol.109.008680
Publikováno v:
Journal of Andrology. 31:365-371
Glucocorticoid (GC) inhibits testosterone production in adult Leydig cells by the glucocorticoid receptor (GR). However, whether GC affects the development of Leydig cells is unclear. The goal of the present study is to investigate the effects of GC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f77795ccdac84f8d607fa8b75331b19
https://doi.org/10.2164/jandrol.109.009019
https://doi.org/10.2164/jandrol.109.009019
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 118:13-17
Perfluorooctane acid (PFOA) is classified as a persistent organic pollutant and as an endocrine disruptor. The mechanism by which PFOA causes reduced testosterone production in males is not known. We tested our hypothesis that PFOA interferes with Le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::897fcb13214209fabd0f3febca408604
https://doi.org/10.1016/j.jsbmb.2009.09.010
https://doi.org/10.1016/j.jsbmb.2009.09.010
Publikováno v:
Chemico-Biological Interactions. 183:79-84
Phthalates are diesters of phthalic acid and an alcohol moiety. Phthalates have been classified as endocrine disruptors and have a broad range of effects with unknown mechanisms. Some of the effects of phthalate are consistent with disruptions of nor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee396082a963aae89fc5690344e583b0
https://doi.org/10.1016/j.cbi.2009.09.014
https://doi.org/10.1016/j.cbi.2009.09.014
Publikováno v:
Acta Biochimica et Biophysica Sinica. 40:979-988
The kidney androgen-regulated protein (Kap) gene is tissue specific and regulated by androgen in mouse kidney proximal tubule cells (PTCs). In the present study, we aimed to identify the minimal PTC-specific androgen-regulated Kap promoter and analyz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9daeb82866a8c5ad09418681f8c6d26b
https://doi.org/10.1111/j.1745-7270.2008.00482.x
https://doi.org/10.1111/j.1745-7270.2008.00482.x
Autor:
Chantal M. Sottas, Syed A. Latif, Ren-Shan Ge, Enmei Niu, Dianne O. Hardy, Qiang Dong, Matthew P. Hardy, James F. Catterall, David J. Morris
Publikováno v:
Endocrinology. 146:2657-2664
Corticosterone (CORT) suppresses Leydig cell steroidogenesis by inhibiting the expression of proteins involved in testosterone biosynthesis including steroidogenic acute regulatory protein and steroidogenic enzymes. In most cells, intracellular gluco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d499e972c75800964cbc6e7bfea3999b
https://doi.org/10.1210/en.2005-0046
https://doi.org/10.1210/en.2005-0046
Autor:
Anna Meseguer, James F. Catterall, Esther Solé, Anna Menoyo, Dianne O. Hardy, Olga Tornavaca, Alain Vandewalle, Montse Soler
Publikováno v:
Biochemical Journal. 366:757-766
The kidney androgen-regulated protein (KAP) is specifically expressed and differentially regulated by androgens and tri-iodothyronine (T3) in intact mouse early (PCT) and late (PR) proximal-tubule cells. Until now, detailed characterization of the mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9eaddf4ffaf9a5d8ec16aeb26c634c
https://doi.org/10.1042/bj20011807
https://doi.org/10.1042/bj20011807
Autor:
Matthew P. Hardy, Trevor M. Penning, Ren-Shan Ge, James F. Catterall, Dianne O. Hardy, Yong-tai Hou
Publikováno v:
Endocrinology. 141:1608-1617
Dihydrotestosterone (DHT) is the most potent naturally occurring androgen, and its production in the testis may have important consequences in developmental and reproductive processes. In the rat testis, three factors can contribute to intracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bab0ca65905b0b331b92699abac2e556
https://doi.org/10.1210/endo.141.5.7445
https://doi.org/10.1210/endo.141.5.7445
Publikováno v:
Biology of Reproduction. 60:855-860
The enzyme 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) has an important role in androgen metabolism, catalyzing the interconversion of dihydrotestosterone (DHT) and 5alpha-androstane-3alpha,17beta-diol (3alpha-DIOL). The net direction of this in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed19f311d4f6d81ebde4aa7afba2debe
https://doi.org/10.1095/biolreprod60.4.855
https://doi.org/10.1095/biolreprod60.4.855