Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Dianne M.A. van den Heuvel"'
Autor:
Joachim G.J.V. Aerts, Els M. E. Verdegaal, Reno Debets, Ellen Kapiteijn, Ron H.J. Mathijssen, Mandy van Brakel, Reinhard Dummer, Rik de Wijn, John P. Groten, Harmen J.G. van de Werken, Mitchell P. Levesque, Dianne M.A. van den Heuvel, Edwin A. Basak, Cor H. J. Lamers, Marij J. P. Welters, Sjoerd H. van der Burg, Daan P. Hurkmans, Rob Ruijtenbeek, Lies Hovestad, Herbert M Pinedo, Sabrina A. Hogan
Publikováno v:
Journal for ImmunoTherapy of Cancer, 8(2):e001607. BioMed Central Ltd.
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, 8(2). BMJ PUBLISHING GROUP
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, 8(2). BMJ PUBLISHING GROUP
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
BackgroundMany cancer patients do not obtain clinical benefit from immune checkpoint inhibition. Checkpoint blockade targets T cells, suggesting that tyrosine kinase activity profiling of baseline peripheral blood mononuclear cells may predict clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f50b4ba6b119b5f029d84a4c81d150
https://pure.eur.nl/en/publications/2106b26b-a581-4468-9d95-68a84487825e
https://pure.eur.nl/en/publications/2106b26b-a581-4468-9d95-68a84487825e
Autor:
Max Koppers, Jeroen den Hertog, Dianne M.A. van den Heuvel, Stefano Dini Modigliani, R. Jeroen Pasterkamp, Eleonora Aronica, Jasper J. Anink, Anne Snelting, Anna M. Blokhuis, Irene Bozzoni, Leonard H. van den Berg, Femke van Diggelen, Jeroen Demmers, Ewout J N Groen, Katsumi Fumoto, Bert M. Verheijen, Peter Sodaar, Jan H. Veldink
Publikováno v:
Acta Neuropathologica. Springer Verlag GmbH
Acta Neuropathologica
Acta Neuropathologica, 132(2), 175-196. Springer Verlag
Acta Neuropathologica, 132(2), 175–196. Springer Verlag
Acta Neuropathologica, 132(2), 175-196. Springer-Verlag
Acta neuropathologica, 132(2), 175-196. Springer Verlag
Acta Neuropathologica
Acta Neuropathologica, 132(2), 175-196. Springer Verlag
Acta Neuropathologica, 132(2), 175–196. Springer Verlag
Acta Neuropathologica, 132(2), 175-196. Springer-Verlag
Acta neuropathologica, 132(2), 175-196. Springer Verlag
Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease with no effective treatment available. An increasing number of genetic causes of ALS are being identified, but how these genetic defects lead to motor neuron degeneration and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ed0db96ed3b96d3c9b2245a0badd8bc
https://doi.org/10.1007/s00401-016-1575-8
https://doi.org/10.1007/s00401-016-1575-8
Autor:
Nathalie Cassoux, Sergio Roman-Roman, Didier Decaudin, Pauline Hascoet, Emilie Vinolo, Richard Marais, Mehmet Dogrusöz, Annemijn P A Wierenga, Antoine Prestat, Katharina Mahal, Bettina Ryll, Aart J. Jochemsen, Martyna Elas, Lenha Mobuchon, Martine J. Jager, Kseniya A. Glinkina, Helen Kalirai, Sarah E. Coupland, Samar Alsafadi, Fariba Nemati, Rob Ruijtenbeek, André Valente, Pieter A. van der Velden, Manuel Rodrigues, Bożena Romanowska-Dixon, Marc-Henri Stern, Raymond L. Barnhill, Olivier Lantz, Francesca Precazzini, Sophie Lebel-Binay, Sophie Piperno-Neumann, Dianne M.A. van den Heuvel, Maria Caterina Mione, B. E. Snaar-Jagalska, Laurence Desjardins, Gülçin Gezgin, Jennifer Sengenés, Arwin Groenewoud, Viviana Anelli, Rogier J. Nell, Liesbeth Houkes
Publikováno v:
Impact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3a35d1ef3263f83d09986577280801e
Autor:
Ron H.J. Mathijssen, Joachim G.J.V. Aerts, Ellen Kapiteijn, Els M. E. Verdegaal, John P. Groten, Rob Ruijtenbeek, Sabrina Schindler, Edwin A. Basak, Mitchell P. Levesque, Marij J. P. Welters, Sjoerd H. van der Burg, Reinhard Dummer, Daan P. Hurkmans, Rik de Wijn, Dianne M.A. van den Heuvel, Stijn L.W. Koolen
Publikováno v:
Journal of Clinical Oncology. 36:9579-9579
9579Background: Prediction of clinical responses to checkpoint inhibitor therapies is urgently needed. Notably, a significant proportion of patients does not benefit from the treatment, agents are ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef440f81a62d0d6e7ee6ecbb047ba8e4
https://doi.org/10.1200/jco.2018.36.15_suppl.9579
https://doi.org/10.1200/jco.2018.36.15_suppl.9579
Publikováno v:
Trends in molecular medicine. 20(1)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease caused by the loss of lower and upper motor neurons leading to progressive muscle weakness and respiratory insufficiency. No treatment is currently available to cure ALS. Recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e68e47884cd7b37fac39ebf10292b69
https://pubmed.ncbi.nlm.nih.gov/24140266
https://pubmed.ncbi.nlm.nih.gov/24140266
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 2, p e55828 (2013)
PLoS ONE, Vol 8, Iss 2, p e55828 (2013)
Neogenin has been implicated in a variety of developmental processes such as neurogenesis, neuronal differentiation, apoptosis, migration and axon guidance. Binding of repulsive guidance molecules (RGMs) to Neogenin inhibits axon outgrowth of differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce6368a4e39dfbffde83511236a2150f
http://europepmc.org/articles/PMC3573027
http://europepmc.org/articles/PMC3573027
Autor:
Anna M. Blokhuis, Dianne M.A. van den Heuvel, Joo-Yeon Engelen-Lee, Max Koppers, R. Jeroen Pasterkamp, Wim G. M. Spliet, Jeroen Demmers, Femke van Diggelen, Yeping Zhou, Janine Kirby, Ewout J N Groen, Jan H. Veldink, Katsumi Fumoto, Eleonora Aronica, Pamela J. Shaw, Leonard H. van den Berg, Jessica van Heest
Publikováno v:
Human molecular genetics, 22(18), 3690-3704. Oxford University Press
Human Molecular Genetics, 22(18), 3690-3704. Oxford University Press
Human Molecular Genetics; Vol 22
Human Molecular Genetics, 22(18), 3690-3704. Oxford University Press
Human Molecular Genetics; Vol 22
Mutations in the RNA binding protein fused in sarcoma/translated in liposarcoma (FUS/TLS) cause amyotrophic lateral sclerosis (ALS). Although ALS-linked mutations in FUS often lead to a cytosolic mislocalization of the protein, the pathogenic mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0c4b070f27fa2f3abf563f8e297daf0
https://pure.amc.nl/en/publications/alsassociated-mutations-in-fus-disrupt-the-axonal-distribution-and-function-of-smn(01550c45-57cc-465c-9e73-ea6d9ec9ef14).html
https://pure.amc.nl/en/publications/alsassociated-mutations-in-fus-disrupt-the-axonal-distribution-and-function-of-smn(01550c45-57cc-465c-9e73-ea6d9ec9ef14).html
Autor:
Keith M. Garner, Dianne M.A. van den Heuvel, Marijke W A de Backer, Maike A.D. Brans, Mieneke C. M. Luijendijk, R. Jeroen Pasterkamp, Roger A.H. Adan
Publikováno v:
BMC Neuroscience, Vol 11, Iss 1, p 94 (2010)
BMC Neuroscience
BMC Neuroscience
Background Multiple neuropeptides, sometimes with opposing functions, can be produced from one precursor gene. To study the roles of the different neuropeptides encoded by one large precursor we developed a method to overexpress minigenes and establi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98d08fea438d087efbafb825f01689b4
http://www.biomedcentral.com/1471-2202/11/94
http://www.biomedcentral.com/1471-2202/11/94
Autor:
Sharon M. Kolk, Youri Adolfs, Dianne M.A. van den Heuvel, Rou Afza F. Gunput, Alex L. Kolodkin, Anita J. C. G. M. Hellemons, R. Jeroen Pasterkamp, Tracy S. Tran, Marten P. Smidt, Asheeta A. Prasad, J. Peter H. Burbach, David D. Ginty
Publikováno v:
The Journal of Neuroscience, 29, 40, pp. 12542-12557
The Journal of Neuroscience, 29, 12542-12557
The Journal of Neuroscience, 29, 12542-12557
Dopaminergic neurons in the mesodiencephalon (mdDA neurons) make precise synaptic connections with targets in the forebrain via the mesostriatal, mesolimbic, and mesoprefrontal pathways. Because of the functional importance of these remarkably comple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd70c1ec7b2fa3c94794ddf8a86964b
https://doi.org/10.1523/JNEUROSCI.2521-09.2009
https://doi.org/10.1523/JNEUROSCI.2521-09.2009
Autor:
Christian Siebold, Eljo Y. van Battum, Rebekka A. Schwab, Lina Malinauskaite, R.A. Robinson, A. Radu Aricescu, Pavol Zelina, B. Bishop, Marleen H. van den Munkhof, R. Jeroen Pasterkamp, O. Dudukcu, Lieke L. van de Haar, Tomas Malinauskas, Jonathan Elegheert, Sara Brignani, S.C. Griffiths, Dianne M.A. van den Heuvel, Anna A. De Ruiter, D. Karia
Publikováno v:
Cell
Cell, Elsevier, 2021, 184 (8), pp.2103-2120.e31. ⟨10.1016/j.cell.2021.02.045⟩
Cell, Elsevier, 2021, 184 (8), pp.2103-2120.e31. ⟨10.1016/j.cell.2021.02.045⟩
Summary During cell migration or differentiation, cell surface receptors are simultaneously exposed to different ligands. However, it is often unclear how these extracellular signals are integrated. Neogenin (NEO1) acts as an attractive guidance rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dca31a627bec6a995e42a81ab33350a